GEO DataSets

(Submitter supplied) These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6238

11 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Latexin is a hematopoietic stem cells (HSCs) and progenitor cells (HPCs) regulatory gene. Its deletion leads to the expansion of HSC and HPC population. The underlying mechanims are largely unknown. We therefore perfored microarrary analysis in HPCs with (Lxn-/-) and without (wild-type, WT) latexin deletion, and determined genes that were altered by latexin deletion. This led us to identify the molecular mechanims by which latexin regulates HSC function.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) Latexin is a hematopoietic stem cell (HSC) regulatory gene. Its deletion leads to the expansion of HSC population. The underlying mechanims are largely unknown. We therefore perfored microarrary analysis in HSCs with (Lxn-/-) and without (wild-type, WT) latexin deletion, and determined genes that were altered by latexin deletion. This led us to identify the molecular mechanims by which latexin regulates HSC function.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) Hematopoietic stem cells (HSCs) and lymphoid-primed multi-potential progenitors (LMPPs) are able to initiate both lymphoid and myeloid differentiation. We show here that the transcriptional repressor Gfi1 (growth factor independence 1) implements a specific gene expression program in HSCs and LMPPs that is critical for their survival and lymphoid differentiation potential. We present evidence that Gfi1 is required to maintain expression of genes involved in lymphoid development such as Flt-3, IL7R, Ebf1, Rag1, CCR9 and Notch1 and controls myeloid lineage commitment by regulating expression of genes such as Hoxa9 or M-CSFR. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4204

Platform:

GPL339

6 Samples

Download data: CEL, CHP

Analysis of Lin-Sca1+ckit+Flt3- (LSKFlt3-) hematopoietic stem cells (HSC) depleted of growth factor independence 1 (Gfi1). Transcriptional repressor Gfi1 restricts HSC proliferation and is essential to self-renewal. Results provide insight into molecular mechanisms underlying Gfi1 effects in HSCs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE20282

6 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

12 Samples

Download data: IDAT

(Submitter supplied) This study aimed at identifying the differences in expression levels between wt and Mant4-/- HSCs after transplantation, to determine the mechanism through which Mant4-/- gain a proliferative advantage.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

6 Samples

Download data: IDAT, TXT

(Submitter supplied) This study aimed at identifying the differences in expression levels between HSCs isolated from PBS or IFNa treated mice to determine the mechanism of activation of HSCs by IFNa.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

6 Samples

Download data: IDAT, TXT

(Submitter supplied) We compared gene expression differences in Atxn1L knockout vs wildtype HSCs KO allele described in Pub Med ID: 22014525

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5002

Platform:

GPL1261

5 Samples

Download data: CEL

Analysis of hematopoietic stem cells (HSCs) purified from the bone marrow of Ataxin-1-like (Atxn1L) null C57Bl/6 mice at 8 weeks of age. The ataxia-associated Atxn1L gene is highly expressed in HSCs. Results provide insight into the role of Atxn-1L in HSC function.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE44285

5 Samples

Download data: CEL

(Submitter supplied) We have combined large-scale mRNA expression and gene mapping methods to identify genes and loci that control hematopoietic stem cell (HSC) functioning. mRNA expression levels were measured in purified HSC isolated from a panel of densely genotyped recombinant inbred mouse strains. Quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts were mapped. Comparison of the physical transcript position with the location of the controlling QTL identified polymorphic cis-acting stem cell genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1077

Platform:

GPL81

44 Samples

Download data: CEL, EXP

Expression profiling of Lin- Sca-1+ c-kit+ hematopoietic stem cells (HSC) from 22 different BXD recombinant inbred (RI) strains. Each RI strain is homozygous for alleles at about 98% of loci. Results combined with QTL mapping to identify candidate genes for the control of HSC function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 22 strain sets

Platform:

GPL81

Series:

GSE2031

44 Samples

Download data: CEL, EXP

(Submitter supplied) To investigate the molecular mechanism underlying gender-specific regulation of hematopoiesis by Lxn. RNA sequencing was performed on LSK cells that were isolated from male and female WT and Lxn-/- mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

14 Samples

Download data: RESULTS