Similar studies for GEO DataSets (Select 200023806) - GEO DataSets

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Items: 20

Select item 2000238061.

Expression data of glioblastoma stem-like (GS) cell lines, conventional glioma cell lines and primary tumors

(Submitter supplied) We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We used Affymetrix HG-U133 Plus 2.0 microarrays to compare human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3885
Platform:: GPL570
92 Samples

Download data: CEL, EXP

Series

Accession:: GSE23806

ID:: 200023806

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000080492.

Expression analyses of glioblastoma derived neurosphere cultures

(Submitter supplied) Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL, EXP

Series

Accession:: GSE8049

ID:: 200008049

Select item 38853.

Glioblastoma stem-like cell lines, glioblastomas, and glioma cell lines

Analysis of glioblastoma stem-like (GS) cell lines, corresponding glioblastoma primary tumors, conventional glioma cell lines, and GS neurospheres. Results provide insight into cell lines recapitulating transcriptional aspects of glioblastomas, thereby allowing identification of therapeutic targets.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 7 specimen sets

Platform:: GPL570
Series:: GSE23806
92 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS3885

ID:: 3885

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000071814.

CD133+ and CD133- CSC lines in primary human GBM

(Submitter supplied) We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-like, non-adherent growth pattern. In contrast, 4 out of 15 cell lines derived from primary GBM grew adherent in vitro and were driven by CD133- tumor cells that fulfilled stem cell criteria. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2728
Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE7181

ID:: 200007181

Select item 27285.

CD133+ and CD133- glioblastoma-derived cancer stem cell lines

Comparison of CD133+ and CD133- glioblastoma-derived cancer stem cells (CSC). Both CSC subpopulations were derived from primary glioblastomas. Results provide insight into the role of CD133+ and CD133- CSCs in the pathogenesis of glioblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell line sets

Platform:: GPL570
Series:: GSE7181
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2728

ID:: 2728

Select item 2000051076.

Distinct Transcription Profiles of Primary and Secondary Glioblastomas

(Submitter supplied) Gene expression data of primary and secondary glioblastoma subgroups. Keywords: glioblastoma, transcription profiles

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
83 Samples

Download data

Series

Accession:: GSE5107

ID:: 200005107

Select item 2000050827.

SNP Analysis of Primary Glioblastoma Cell Lines

(Submitter supplied) Genomic abnormalities that are associated with mesecnhmal phenotype of GBM were detected in glioblastoma cell lines. Keywords: SNP array analysis of glioblastome cell lines.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL1266
5 Samples

Download data

Series

Accession:: GSE5082

ID:: 200005082

PubMed Similar studies

Select item 2000171018.

Expression profiles of mouse glioma-initiating cell-like subclones

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE17101

ID:: 200017101

Select item 2000170769.

Expression profiling of sox11-expressing glioma-initiating cell-like cells

(Submitter supplied) To identify factors involved in tumorigenicity of glioma-initiating cells (GICs), we compared gene expression in GIC-like cells with and without sox11 expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE17076

ID:: 200017076

Select item 20001706210.

Expression profiling of mouse glioma-initiating cell-like cells (GICs) and non-GICs

(Submitter supplied) To identify factors involved in glioma-initiating cells (GICs), we compared gene expression between GIC-like cells and non-GICs.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE17062

ID:: 200017062

Select item 20002001811.

Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased tumor YB-1 expression

(Submitter supplied) Our aim was to gain insight into the molecular pathways that distinguish pediatric- from adult-onset glioblastomas.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9966
60 Samples

Download data: TXT

Series

Accession:: GSE20018

ID:: 200020018

Select item 20003642612.

The MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype

(Submitter supplied) Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosine kinase receptor for HGF, associates with mesenchymal and proneural neurospheres (Met-pos-NS). Met expression is almost absent from classical neurospheres (Met-neg-NS), and mutually exclusive with amplification and expression of the EGF receptor gene. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
37 Samples

Download data: TXT

Series

Accession:: GSE36426

ID:: 200036426

Select item 20003126213.

Comparison study of glioma stem cells and adult human neural stem cells

(Submitter supplied) Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to glioblastoma stem-like cells have not been consistently determined. Towards this goal we have provided an internally coherent molecular reference that compares adult neural and glioblastoma stem cells cultivated under identical conditions. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL2986
14 Samples

Download data: TXT

Series

Accession:: GSE31262

ID:: 200031262

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004456114.

Effect of Notch1 pathway activation on high-grade glioma cells

(Submitter supplied) In this study, we explored the transcriptomic consequences of strong activation of the Notch pathway in embryonic human neural stem cells and in gliomas. For this we used a forced expression of the Notch intracellular domain (NICD). Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial cells in neurovascular niches. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5671
Platform:: GPL11532
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE44561

ID:: 200044561

Select item 567115.

Notch1 stimulation effect on glioblastoma stem cell cultures

Analysis of Gb4 and Gb7 glioma cancer stem cells following forced expression of the Notch1 intracellular domain (NICD) to activate the Notch1 signaling pathway. Results provide insight into a role for the Notch1 pathway in glioblastoma stem cell plasticity and angiogenic properties.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 cell type, 2 genotype/variation sets

Platform:: GPL11532
Series:: GSE44561
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5671

ID:: 5671

Select item 20008874016.

Expression data of J3T-1 and J3T-2 glioma

(Submitter supplied) We established two novel glioma subclones those showed different invasive and angiogenic phenotypes. J3T-1 demonstrates robust angiogenesis and perivascular invasion. J3T-2 demonstrates diffuse invasion along white matter tracts. We used microarrays to show the difference of gene expression that contribute to the difference of phenotype.

Organism:: Canis lupus familiaris

Type:: Expression profiling by array

Platform:: GPL3738
2 Samples

Download data: CEL

Series

Accession:: GSE88740

ID:: 200088740

Select item 20004511717.

Hypoxia and oxygenation induce a metabolic switch between the pentose phosphate pathway and glycolysis in glioma stem-like cells

(Submitter supplied) Oxygen fluctuation during tissue remodeling imposes a major metabolic challenge in human tumors. Stem-like tumor cells in glioblastomas are believed to possess extraordinary metabolic flexibility, enabling them to initiate growth even under non-permissive conditions. To identify adaptive response mechanism, we compared the effects of acute and chronic hypoxia versus oxygenation on stem-like glioblastoma (GS) cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
20 Samples

Download data: CEL

Series

Accession:: GSE45117

ID:: 200045117

Select item 20009879718.

Chronophin regulates metabolic and transcriptomic features of glioblastoma stem-like cells

(Submitter supplied) High throughput sequencing of poly-A RNA

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
17 Samples

Download data: TXT

Series

Accession:: GSE98797

ID:: 200098797

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20000703819.

RLSC and MMH-D3 cell lines

(Submitter supplied) Increasing evidence provide support that the mammalian liver contains stem/progenitor cells, but their molecular phenotype, embryological derivation, cell biology as well as of their role in the liver cell turnover and regeneration remain to be further clarified. We report the isolation, characterization and reproducible establishment in line of a resident liver stem cell (RLSC) with immunophenotype and differentiative potential distinct from other previously reported liver precursor/stem cells. more...