Similar studies for GEO DataSets (Select 200028354) - GEO DataSets

Select item 2000283541.

Effects of bisphenol A on ovarian gene expression in fathead minnows and zebrafish

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Pimephales promelas; Danio rerio

Type:: Expression profiling by array

Platforms:: GPL6457 GPL9248
66 Samples

Download data: TXT

Series

Accession:: GSE28354

ID:: 200028354

Select item 2000283532.

Effects of bisphenol A on ovarian gene expression in fathead minnows and zebrafish [FHM data set]

(Submitter supplied) Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted endpoints with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 µg BPA caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL9248
32 Samples

Download data: TXT

Series

Accession:: GSE28353

ID:: 200028353

Select item 2000283513.

Effects of bisphenol A on ovarian gene expression in fathead minnows and zebrafish [ZF data set]

(Submitter supplied) Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted endpoints with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 µg BPA caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL6457
34 Samples

Download data: TXT

Series

Accession:: GSE28351

ID:: 200028351

Select item 2000270674.

Comparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure

(Submitter supplied) Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses by comparing ecotoxicological, developmental, and genomic data to quantitatively determine the relative sensitivity of two common model aquatic vertebrates to assess the potential for developing refined safety factors among species. more...

Organism:: Danio rerio; Pimephales promelas

Type:: Expression profiling by array

Platforms:: GPL7301 GPL10259
59 Samples

Download data: TXT

Series

Accession:: GSE27067

ID:: 200027067

Select item 2000364675.

A Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL10259
23 Samples

Download data: TXT

Series

Accession:: GSE36467

ID:: 200036467

Select item 2000364666.

A Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Recovery phase

(Submitter supplied) Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to greater than 10 ng/L. Little is known, however, concerning the toxicological potency of DES in fish. In this study, sexually-mature fathead minnows (Pimephales promelas) of both sexes were exposed to 1, 10 or 100 ng DES/L water in a flow-through system. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL10259
11 Samples

Download data: TXT

Series

Accession:: GSE36466

ID:: 200036466

Select item 2000364657.

A Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Exposure Phase

(Submitter supplied) Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to greater than 10 ng/L. Little is known, however, concerning the toxicological potency of DES in fish. In this study, sexually-mature fathead minnows (Pimephales promelas) of both sexes were exposed to 1, 10 or 100 ng DES/L water in a flow-through system. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL10259
12 Samples

Download data: TXT

Series

Accession:: GSE36465

ID:: 200036465

Select item 2000602028.

Natural Variation in Fish Transcriptomes: Comparative Analysis of the Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Pimephales promelas

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL10259
511 Samples

Download data: TXT

Series

Accession:: GSE60202

ID:: 200060202

PubMed Full text in PMC Similar studies

Select item 2000601679.

Natural Variation in Fish Transcriptomes: Comparative Analysis of the Zebrafish (Danio rerio)

(Submitter supplied) Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, there needs to be a better characterization and understanding of the natural variation in gene expression among fish individuals within populations. Little effort, however, has been made in this area. more...

Organism:: Danio rerio

Type:: Third-party reanalysis; Expression profiling by array

Download data: TXT

Series

Accession:: GSE60167

ID:: 200060167

PubMed Full text in PMC Similar studies

Select item 20006012610.

Natural Variation in Fish Transcriptomes: Comparative Analysis of the Fathead Minnow (Pimephales promelas)

(Submitter supplied) Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, there needs to be a better characterization and understanding of the natural variation in gene expression among fish individuals within populations. Little effort, however, has been made in this area. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL10259
511 Samples

Download data: TXT

Series

Accession:: GSE60126

ID:: 200060126

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001521611.

Effects of haloperidol on zebrafish and fathead minnow gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio; Pimephales promelas

Type:: Expression profiling by array

Platforms:: GPL7282 GPL6563
24 Samples

Download data: TXT

Series

Accession:: GSE15216

ID:: 200015216

Select item 20001511512.

Small fish comp tox FHM haloperidol 96 h ovary

(Submitter supplied) This experiment was conducted as part of an overall study aimed at examining effects of a dopamine receptor antagonist on reproduction, behavior, and gene expression in cyprinid fish. Relative to gene expression, we hypothesized that if haloperidol disrupted normal regulation of the HPG axis, there may be robust transcriptional alterations in the ovary of exposed females that might serve as useful markers of exposure and/or effects. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL7282
12 Samples

Download data: TXT

Series

Accession:: GSE15115

ID:: 200015115

Select item 20001486113.

Small fish comp tox ZF haloperidol 96 h ovary

(Submitter supplied) This experiment was conducted as part of an overall study aimed at examining effects of a dopamine receptor antagonist on reproduction, behavior, and gene expression in cyprinid fish. Relative to gene expression, we hypothesized that if haloperidol disrupted normal regulation of the HPG axis, there may be robust transcriptional alterations in the ovary of exposed females that might serve as useful markers of exposure and/or effects. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL6563
12 Samples

Download data: TXT

Series

Accession:: GSE14861

ID:: 200014861

Select item 20001825414.

Influence of Gross Ovarian Stage on Transcript Profiles in Fathead Minnow (Pimephales promelas) Ovary Tissue

(Submitter supplied) Interpretation of toxicogenomic experiments conducted with ovary tissue from asynchronous-spawning small fish species are complicated by background variation in the relative abundance and proportion of follicles at different stages within the ovary tissue sample. This study employed both real-time quantitative PCR and a 15,000 gene oligonucleotide microarray to examine variation in the fathead minnow (Pimephales promelas) ovarian transcriptional profile as a function of quantitative and qualitative differences in ovarian histology. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL9248
30 Samples

Download data: TXT

Series

Accession:: GSE18254

ID:: 200018254

Select item 20000840415.

Influence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)

(Submitter supplied) Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of action (MOA). To more clearly define the water chemistry parameters mediating Pb toxicity we evaluated the effects of hardness (as CaSO4) and DOC (as humic acid (HA)) during chronic (150d) exposures to the fathead minnow (Pimephales promelas). more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL5443
30 Samples

Download data: GPR

Series

Accession:: GSE8404

ID:: 200008404

Select item 20002695816.

Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas)

(Submitter supplied) Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic-pituitary-gonadal (HPG) axis. To determine the short-term impacts of prochloraz on gene expression and steroid production, adult female fathead minnows (Pimephales promelas) were exposed to the chemical (0 or 300 μg/L) for a time-course of 6, 12 and 24 h. Consistent with inhibition of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) and aromatase (CYP19), known molecular targets of prochloraz, plasma 17β-estradiol (E2) was reduced within 6 hours. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL9248
23 Samples

Download data: TXT

Series

Accession:: GSE26958

ID:: 200026958

Select item 20007093617.

Global ovary gene interaction network structure informs biological effects of Chemical stressors

(Submitter supplied) Background: Complex biological networks control fundamental processes such as reproduction. The relationship of network structure to biological function was investigated in a global gene interaction network developed from ovary tissues of the model fish, fathead minnow (Pimephales promelas). Results: A global ovary gene interaction network was inferred from gene expression in ovaries of fathead minnow representing 288 different exposure conditions and 1,472 microarrays. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL10259
1470 Samples

Download data: TXT

Series

Accession:: GSE70936

ID:: 200070936

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007080718.

Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles

(Submitter supplied) Modeled on human connectivity mapping (Cmap), this study was undertaken to investigate the potential applications of Cmap approach in ecotoxicology. Over 3500 zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) transcriptomic profiles, each associated with one of several dozen chemical treatment conditions, were compiled into three distinct collections of rank-ordered gene lists (ROGLs) by species and microarray platforms. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platforms:: GPL9248 GPL15775
580 Samples

Download data: TXT

Series

Accession:: GSE70807

ID:: 200070807

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003807019.

Discovery and validation of gene classifiers for endocrine disrupting chemicals in Zebrafish (Danio rerio)

(Submitter supplied) Background: Development and application of transcriptomics-based gene classifiers for ecotoxicological applications lag far behind those of human biomedical science. Many such classifiers discovered thus far lack vigorous statistical and experimental validations, with their stability and reliability unknown. A combination of genetic algorithm/support vector machines and genetic algorithm/K nearest neighbors were used in this study to search for classifiers of endocrine disrupting chemicals (EDCs) in zebrafish. more...