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Links from GEO DataSets

Items: 20

1.

Cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL6982 GPL6102
94 Samples
Download data
Series
Accession:
GSE32979
ID:
200032979
2.

Genome-wide SNP analysis of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients

(Submitter supplied) The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen is an important risk factor for SCC development in OTRs. Various gene mutations (e.g. TP53) and genetic alterations (e.g. CDKN2A loss, RAS amplification) have been found in SCCs. The aim of this study was to identify genomic alterations that are consistently involved in the formation of SCCs and their precursor lesions, actinic keratoses (AKs). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL6982 GPL6102
94 Samples
Download data: TXT
Series
Accession:
GSE32969
ID:
200032969
3.

Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients

(Submitter supplied) The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen is an important risk factor for the development of SCC in OTRs. Various gene mutations (e.g. TP53) and genetic alterations (e.g. loss of CDKN2A, amplification of RAS) have been found in SCCs. The aim of this genome-wide study was to identify pathways that are consistently involved in the formation of SCCs and their precursor lesions, actinic keratoses (AKs). To perform the analysis in an isogenic background, RNA and DNA were isolated from normal (unexposed) epidermis, benign AK, and SCC from each of 15 OTRs. Hierarchical cluster analysis of mRNA expression profiles showed SCC, AK and epidermal samples to separate into three distinct groups. Several thousand genes were differentially expressed between epidermis, AK and SCC; most upregulated in SCCs were genes related to hyperproliferation and stress markers, such as keratin 6 (KRT6), KRT16 and KRT17. Matching to oncogenic pathways revealed activation of downstream targets of RAS and cMYC in SCCs and of NFkappaB and TNF already in AKs.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6102
42 Samples
Download data: TXT
Series
Accession:
GSE32628
ID:
200032628
4.

Novel Molecular Markers for non-melanoma skin cancer

(Submitter supplied) normal skin (no), actinic keratosis (ak), and squamous cell carcinoma (scc) of the skin were examined: Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. The type and number of genes involved in non-melanoma skin cancer (NMSC) are still unclear. This study examined and identified different expressed genes in NMSC. Fifteen snap-frozen biopsies of five immunosuppressed organ-transplanted recipients each normal skin, actinic keratosis (AK) and invasive squamous cell carcinoma (SCC) were analysed. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2200
Platform:
GPL96
15 Samples
Download data
Series
Accession:
GSE2503
ID:
200002503
5.
Full record GDS2200

Non-melanoma skin cancer

Analysis of normal skin, actinic keratotic (AK) lesion, and squamous cell carcinoma (SCC) tumor biopsies from 5 patients with non-melanoma skin cancer (NMSC). Results provide insight into the molecular pathogenesis of NMSC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL96
Series:
GSE2503
15 Samples
Download data
6.

Transcriptomic study on human skin samples: identification of actinic keratoses two risk classes.

(Submitter supplied) Gene expression profile analysis allowed to identify 2 classes of AK.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
72 Samples
Download data: TXT
Series
Accession:
GSE207744
ID:
200207744
7.

Progression from actinic keratosis to cutaneous squamous cell carcinoma involves miR-204 silencing and a switch towards STAT3 activation

(Submitter supplied) Squamous cell carcinoma is the second most common skin cancer and frequently progress from an intraepithelial actinic keratosis. The role of microRNAs during the progression from actinic keratosis to cutaneous squamous cell carcinoma (cSCC) remains to be elicited. By using an Agilent microRNA expression microarray we found the expression of miR-204 to be markedly downregulated in cSCC when compared to actinic keratoses. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
4 Samples
Download data: CEL
Series
Accession:
GSE71953
ID:
200071953
8.

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

(Submitter supplied) Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to investigate the transcriptomes of cSCC and actinic keratoses (AK), to elucidate key differences between precursor AK lesions and invasive carcinoma. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
40 Samples
Download data: CEL
Series
Accession:
GSE45216
ID:
200045216
9.

Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma

(Submitter supplied) Primary tumor recurrence occurs commonly after surgical resection of lung squamous cell carcinoma (SCC). The aim of this study was to identify genes involved in recurrence in lung squamous cell carcinoma patients. Array comparative genomic hybridization (aCGH) was performed on DNA extracted from tumour tissue from 62 patients with primary lung squamous cell carcinomas. aCGH data was analysed to identify genes affected by copy number alterations that may be involved in SCC recurrence. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL2879
62 Samples
Download data: TXT
Series
Accession:
GSE32058
ID:
200032058
10.

Identification of transcriptomic drivers of squamous cell carcinoma development through a preneoplastic intermediate [human RNA-Seq]

(Submitter supplied) Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV-driven Hairless mouse model. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
26 Samples
Download data: TXT
11.

Identification of transcriptomic drivers of squamous cell carcinoma development through a preneoplastic intermediate [mouse RNA-Seq]

(Submitter supplied) Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV-driven Hairless mouse model. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
18 Samples
Download data: TXT
Series
Accession:
GSE84292
ID:
200084292
12.

Identification of transcriptomic drivers of squamous cell carcinoma development through a preneoplastic intermediate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL9115 GPL9250
45 Samples
Download data
Series
Accession:
GSE84194
ID:
200084194
13.

Identification of transcriptomic drivers of squamous cell carcinoma development through a preneoplastic intermediate [human miRNA-Seq]

(Submitter supplied) Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV-driven Hairless mouse model. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL9115
27 Samples
Download data: TXT
Series
Accession:
GSE84193
ID:
200084193
14.

Identification of transcriptomic drivers of squamous cell carcinoma development through a preneoplastic intermediate [mouse miRNA-Seq]

(Submitter supplied) Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV-driven Hairless mouse model. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL9250
18 Samples
Download data: TXT
Series
Accession:
GSE84192
ID:
200084192
15.

Ruxolitinib inhibits Cyclosporine-induced proliferation of cutaneous squamous cell carcinoma

(Submitter supplied) Organ transplant recipients (OTRs) on Cyclosporine A (CSA) are prone to catastrophic cutaneous squamous cell carcinoma (SCC). Allograft-sparing, cancer-targeting systemic treatments are unavailable. We have shown increased risk for catastrophic SCC in OTRs via CSA-mediated induction of Interleukin-22 (IL-22). Herein, we found CSA drives SCC proliferation and tumor growth through IL-22 and JAK/STAT pathway induction. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
23 Samples
Download data: CEL
Series
Accession:
GSE117247
ID:
200117247
16.

A molecular signature for rejuvenation characterizes lesional and non lesional skin following Metvix treatment in Actinic Keratosis patients.

(Submitter supplied) Actinic keratoses (AK) are proliferations of pre-neoplastic keratinocytes in the epidermis that are the result of cumulative ultraviolet (UV) radiations from sun exposure. Lesions are commonly found on sites of sun-exposed skin such as the face, balding scalp, and back of the hand. AKs may present on a patient as a few detectable lesions and 5-10% of them are susceptible to transform into SCC. In contrast, Organ Transplant Recipients (OTR) are of increasing risk at developing cancers as a consequence of long-term immunosuppressive therapy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
35 Samples
Download data: CEL
Series
Accession:
GSE90643
ID:
200090643
17.

Defining an invasion signature at the leading edge of cutaneous squamous cell carcinoma (SCC): IL-24 driven MMP-7 and MMP-13 expression.

(Submitter supplied) Purpose: Primary cutaneous squamous cell carcinoma (SCC) can be an invasive cancer in skin and has the potential to metastasize. We aimed to define the cancer related molecular changes that distinguish non-invasive from invasive SCC. Experimental design: We used laser capture microdissection technique in combination with cDNA microarray analysis in order to determine molecular changes that associate with SCC progression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
25 Samples
Download data: CEL
Series
Accession:
GSE42677
ID:
200042677
18.

Bulk RNA-Seq of actinic keratoses

(Submitter supplied) RNA-Seq was performed on 8 actinic keratoses (AK) to identify differentially expressed genes in AK vs normal skin and cutaneous squamous cell carcinoma
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: TXT
Series
Accession:
GSE261645
ID:
200261645
19.

Transcriptional profiling of skin tumor samples from mice with combintions of Braf, Alk5, p53, Tgfbr2 and Kras mutations

(Submitter supplied) Murine skin tumors following combintions of Braf, Alk5, p53, Tgfbr2 and Kras mutation, under the control of Lgr5CreER.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
40 Samples
Download data: CSV
Series
Accession:
GSE199070
ID:
200199070
20.

Targeted sequencing of localized and metastatic cutaneous squamous cell carcinoma

(Submitter supplied) We report sequencing of 10 localized and 10 metastatic cutaneous squamous cell carcinomas from human subjects. Sequencing was done on an oncology targeted gene mutation panel consisting of 76 genes.
Organism:
Homo sapiens
Type:
Genome variation profiling by high throughput sequencing
Platform:
GPL20301
20 Samples
Download data: XLSX
Series
Accession:
GSE150727
ID:
200150727
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