GEO DataSets

(Submitter supplied) MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf mice that were induced during adulthood showed normal anxiety but increased depression-like behavior, in accordance with pharmacological findings. In contrast, the inactivation of Braf in the juvenile brain leads to normal depression-like behavior but decreased anxiety in adults. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

36 Samples

Download data: TXT

(Submitter supplied) Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here we show altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact in neurogenesis and anxiety- and depression-related behaviors in mice. miR-17-92 deletion in adult neural progenitors causes a decrease, while its overexpression an increase of neurogenesis in the dentate gyrus, through regulating genes in the glucocorticoid pathway, especially serum- and glucocorticoid-inducible protein kinase-1 (Sgk1). more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15103

6 Samples

Download data: TXT

(Submitter supplied) The goal of this study is to compare gene expression of mouse cultured cortical and hippocampal neurons in response of TLR7 defiency at mature stage

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

6 Samples

Download data: XLSX

(Submitter supplied) The goal of this study is to compare gene expression of mouse cultured cortical and hippocampal neurons in response to TLR3, TLR7 and TLR8 activation

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

15 Samples

Download data: TXT, XLSX

(Submitter supplied) We demonstrate that Prnp dosage is critical for the maintenance of neuronal homeostasis since both its absence and, more relevantly, its overexpression induce higher sensitivity to kainate (KA) damage. These data correlate with electrophysiological results in freely behaving mutant mice showing an imbalance in activity-dependent synaptic processes, as determined from input/output curves, paired-pulse facilitation, and LTP studies. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

12 Samples

Download data: TXT

(Submitter supplied) The glucocorticoid receptor overexpression in early life is sufficient to alter gene expression patterns for the rest of the animal's life. Hippocampal dentate gyrus (DG) are more responsive than the nucleus accumbens (NAcc) following the glucocorticoid receptor overexpression in the forebrain.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13763

37 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4001 GDS4002

Platforms:

GPL6481 GPL7467

148 Samples

Download data: TXT

(Submitter supplied) Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior and, consequently, used this as selection criterion for the inbreeding of our animals. In depression-related tests, HAB mice display a more passive, depression-like coping strategy than LAB mice, resembling clinical comorbidity of anxiety and depression as observed in psychiatric patients. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

78 Samples

Download data: TXT

(Submitter supplied) Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior and, consequently, used this as selection criterion for the inbreeding of our animals. In depression-related tests, HAB mice display a more passive, depression-like coping strategy than LAB mice, resembling clinical comorbidity of anxiety and depression as observed in psychiatric patients. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7467

70 Samples

Download data: TXT

Analysis of five brain regions closely connected to the emotion-regulating parts of the limbic system, isolated by LCM from CD-1 males selectively bred for high (HAB), normal (NAB), or low (LAB) anxiety-related behavior. Results provide insight into the molecular mechanisms underlying anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 5 tissue sets

Platform:

GPL6481

Series:

GSE29015

75 Samples

Download data

Analysis of seven brain regions closely connected to the emotion-regulating parts of the limbic system, isolated by micropunching from CD-1 males selectively bred for high (HAB) or low (LAB) anxiety-related behavior. Results provide insight into the molecular mechanisms underlying anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 7 tissue sets

Platform:

GPL7467

Series:

GSE29015

70 Samples

Download data: TXT