GEO DataSets

(Submitter supplied) Transcriptionnal profiling of C. difficile 630E JIR8094 strain vs a ccpA mutant after 10h of growth in TY

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

8 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

16 Samples

Download data: GPR

(Submitter supplied) transcriptionnal profiling of a ccpA mutant of C. difficile strain JIR8094 comparing growth 10h in 0.5% TY medium with growth 10h in TY medium

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

8 Samples

Download data: GPR

(Submitter supplied) transcriptionnal profiling of a C. difficile strain JIR8094 comparing growth 10h in 0.5% TY medium with growth 10h in TY medium

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

8 Samples

Download data: GPR

(Submitter supplied) Transcriptionnal profiling of C. difficile 630E JIR8094 strain vs a ccpA mutant after 10h of growth in TY with 0.5% glucose

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

16 Samples

Download data: GPR

(Submitter supplied) Comparison of ccpA Chromatine immunoprecipitation on chip using 2 strains : JIR8094 (CD630E) wild type strain and a ccpA mutant after 6h of growth in TYG. This experimental procedure was designed to investigate the consensus binding site, CRE, of pleiotropic regulator ccpA.

Organism:

Clostridioides difficile 630; Clostridioides difficile

Type:

Genome binding/occupancy profiling by array

Platform:

GPL15104

3 Samples

Download data: GPR

(Submitter supplied) This study is based on two microarray datasets, in one hand a phase transition comparison using the expression profiles of 630E strain after 4h and 10h of growth. In other hand a comparison at 10h of growth between a mutant of the sigH gene and the WT strains. This experimental procedure was designed to investigate the effect of sigH in the growth phase transition of Clostridium difficile. This SuperSeries is composed of the SubSeries listed below.

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

8 Samples

Download data: GPR

(Submitter supplied) Transcriptionnal profiling of C. difficile 630E strain vs a sigH mutant after 10h of growth in TY

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

4 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of C. difficile 630E strain after 4h vs 10h of growth

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

4 Samples

Download data: GPR

(Submitter supplied) Transcriptionnal profiling of C. difficile 630E strain vs a sigD mutant after 6h of growth in BHI

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

4 Samples

Download data: GPR

(Submitter supplied) Clostridium acetobutylicum is a typical bacterium of major importance to industrial butanol production. In order to dissect the regulatory network pertaining to the industrial application of this bacterium, catabolite control protein A (CcpA) was investigated for its global function by DNA microarray.It showed that CcpA of C. acetobutylicum controls hundreds of genes, not only carbon metabolism, but also solvent production and sporulation in the life cycle.The results here demonstrated that CcpA is an important pleiotropic regulator related to some specific physiological and biochemical process in butanol-producing C. more...

Organism:

Clostridium acetobutylicum

Type:

Expression profiling by array

Platform:

GPL14821

8 Samples

Download data: TXT

(Submitter supplied) In Bacillus cereus the catabolite control protein CcpA was shown to be involved in optimizing the efficiency of glucose catabolism by activating genes encoding glycolytic enzymes including a non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase that mediates conversion of D-glyceraldehyde 3-phosphate to 3-phospho-D-glycerate in one single step, and by repressing genes encoding the citric acid cycle and gluconeogenic enzymes. more...

Organism:

Bacillus cereus ATCC 14579

Type:

Expression profiling by array

Platform:

GPL5161

8 Samples

Download data: TXT

(Submitter supplied) Background The catabolite control protein A (CcpA) is a member of the LacI/GalR family of transcriptional regulators controlling carbon-metabolism pathways in low-GC Gram positive bacteria. It functions as a catabolite repressor or activator, allowing the bacteria to utilize the preferred carbon source over secondary carbon sources. This study is the first CcpA-dependent transcriptome and proteome analysis in S. more...

Organism:

Staphylococcus aureus; Staphylococcus aureus subsp. aureus str. Newman

Type:

Expression profiling by array

Platform:

GPL3931

6 Samples

Download data

(Submitter supplied) We sought to determine how deletion of ccpA affects the gene expression profile in three M serotype strains of group A streptococcus

Organism:

Streptococcus sp. 'group A'

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19691

24 Samples

Download data: TXT

(Submitter supplied) In Gram-positive organisms the general stress response is regulated by the alternative sigma factor sigma B (σB). In C. difficile this sigma factor has been implicated in protection against stressors such as reactive oxygen species and antimicrobial compounds. Here, we show that an anti-σB antibody can be used to demonstrate overexpression of σB in C. difficile and that this overexpression is tolerated for short periods of time, despite its toxicity. more...

Organism:

Clostridioides difficile 630

Type:

Expression profiling by array

Platform:

GPL25054

16 Samples

Download data: TXT, XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platforms:

GPL10556 GPL18319

8 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of C. difficile 630E strain vs. an Hfq antisense after 7.5h of growth inTYt.

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL18319

4 Samples

Download data: GPR, TXT, XLS

(Submitter supplied) Clostridium difficile is an emergent human pathogen and the most common cause of nosocomial diarrhea. Our recent deep-sequencing data strongly suggest the importance of RNA-based mechanisms for the control of gene expression in C. difficile. The RNA chaperon protein Hfq is a key component of post-transcriptional regulatory network in various bacterial systems. In an effort to understand the function of Hfq in C. more...

Organism:

Clostridioides difficile

Type:

Expression profiling by array

Platform:

GPL10556

4 Samples

Download data: GPR, TXT, XLS

(Submitter supplied) In Bacillus subtilis and its relatives carbon catabolite control, a mechanism enabling to reach maximal efficiency of carbon and energy sources metabolism, is achieved by the global regulator CcpA (carbon catabolite protein A). CcpA in a complex with HPr-Ser-P (seryl-phosphorylated form of histidine-containing protein, HPr) binds to operator sites called catabolite responsive elements, cre. Depending on the cre box position relative to the promoter, the CcpA/HPr-Ser-P complex can either act as a positive or a negative regulator. more...

Organism:

Bacillus subtilis

Type:

Expression profiling by array

Platform:

GPL15025

10 Samples

Download data: TXT

(Submitter supplied) CcpA is a global regulator of transcription in Gram-positive bacteria that controls gene expression in response to carbohydrate availability. Using the fructan hydrolase (fruA) gene of S. mutans as a model, we demonstrate that CcpA does indeed play a major role in carbohydrate catabolite repression. Using DNA microarrays, the expression of at least 170 genes differed in CcpA-deficient cells compared to the parental strains when cells are grown in the presence of glucose, but only 90 genes showed altered expression when cells were cultivated in the poorly-repressing substrate galactose. more...

Organism:

Streptococcus mutans

Type:

Expression profiling by array

Platform:

GPL4340

16 Samples

Download data: MEV