GEO DataSets

(Submitter supplied) Using a novel stress paradigm, we generated emotionally stressed, physically stressed, and control animals. We measured changes in mRNA expression using Illumina HiSeq2000 to obtain high-depth sequencing. Interestingly, we observed a number of significantly up- and down-regulated mRNAs. By identifying mRNAs that were regulated similarly in both emotionally and physically stressed mice, we hope to provide a list of potentially novel targets for therapeutic intervention in mood disorder.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

12 Samples

Download data: DIFF, FPKM_TRACKING

(Submitter supplied) While stressful life events are an important cause of psychopathology such as Post-Traumatic Stress Disorder (PTSD) and Major Depressive Disorder (MDD), most individuals exposed to chronic stress remain psychologically unperturbed. The molecular mechanisms such variations in stress resilience remain to be explored. Utilizing a mouse social defeat paradigm as a model for chronic social stress exposure, we segregated socially defeated c57bl/6J mice into Susceptible and Unsusceptible groups based on scores of social avoidance, and these groups differ along multiple behavioral and physiological domains. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

18 Samples

Download data: TXT

(Submitter supplied) Chronic psychosocial stress is a risk factor for psychiatric disorders, and genetic factors interact in conferring susceptibility. The chronic social defeat stress (CSDS) mouse model allows identifying factors underlying resilience and susceptibility to chronic psychosocial stress. Following 10 days of CSDS, we collected the brain and blood tissues. We performed (1) AGO2 RNA immunoprecipitation-sequencing (AGO2 RIP-seq) of active miRNAs and their mRNA targets in the BNST. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:

GPL19057

77 Samples

Download data: TXT

(Submitter supplied) This study explored the interaction of early life and adult stress on transcriptional and chromosomal states in a 2x2 design. Male and female mice were subjected to early life stress (ELS) or were standard-reared (Std), were housed normally through adolescence, and were then exposed to 10 days of control (Ctl) or chronic social defeat stress (CSDS: males only) or 3 days of sub-threshold variable stress (STVS: females only) conditions in adulthood. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL13112 GPL17021

179 Samples

Download data: BW, TXT

(Submitter supplied) Inbred mouse strains differ in their innate anxiety levels. We used RNA-sequencing to identify gene expression differences in hippocampus and frontal cortex of six mouse strains.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

36 Samples

Download data: TXT