U.S. flag

An official website of the United States government

Links from GEO DataSets

Items: 18

1.

Pleiotropic Effects of Deubiquitinating Enzymes on Growth and Pathogenesis of Cryptococcus neoformans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Cryptococcus neoformans var. grubii H99; Cryptococcus neoformans; Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platforms:
GPL10872 GPL4009
26 Samples
Download data
Series
Accession:
GSE36184
ID:
200036184
2.

Comparison of transcription profiles of C. neoformans during rabbit or human infection

(Submitter supplied) Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degradation via the ubiquitination pathway. Cryptococcus neoformans is an important basidiomycete pathogen that causes life-threatening meningoencephalitis primarily within the immunocompromised population. more...
Organism:
Cryptococcus neoformans var. neoformans; Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL4009
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE36183
ID:
200036183
3.

Comparison of transcription profiles for C. neoformans during rabbit infection

(Submitter supplied) Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degradation via the ubiquitination pathway. Cryptococcus neoformans is an important basidiomycete pathogen that causes life-threatening meningoencephalitis primarily within the immunocompromised population. more...
Organism:
Cryptococcus neoformans; Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platform:
GPL4009
4 Samples
Download data: GPR, TXT
Series
Accession:
GSE36182
ID:
200036182
4.

Transcript response of CSF survival mutants in CSF or serum

(Submitter supplied) Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degradation via the ubiquitination pathway. Cryptococcus neoformans is an important basidiomycete pathogen that causes life-threatening meningoencephalitis primarily within the immunocompromised population. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL10872
12 Samples
Download data: GPR, TXT
Series
Accession:
GSE36181
ID:
200036181
5.

Transcriptional changes due to UBP5 mutation under temperature stress

(Submitter supplied) Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degradation via the ubiquitination pathway. Cryptococcus neoformans is an important basidiomycete pathogen that causes life-threatening meningoencephalitis primarily within the immunocompromised population. more...
Organism:
Cryptococcus neoformans var. grubii H99; Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL10872
4 Samples
Download data: GPR, TXT
Series
Accession:
GSE35067
ID:
200035067
6.

Cdk8 and Ssn801 regulate oxidative stress resistance and virulence in Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is an important pathogen that annually kills 200,000 people worldwide. It survives in the environment as a yeast or spore and can also proliferate within host macrophages after being inhaled into the lungs. In conditions of immunocompromise, cryptococcal cells can escape from the lungs to the brain, where they cause a deadly meningoencephalitis that is both difficult and expensive to treat. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19081
21 Samples
Download data: TSV
Series
Accession:
GSE125281
ID:
200125281
7.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity (RNA-Seq)

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27451
56 Samples
Download data: CSV
Series
Accession:
GSE162851
ID:
200162851
8.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL27451
12 Samples
Download data: BED, NARROWPEAK
Series
Accession:
GSE153134
ID:
200153134
9.

Transcrptional profiles of Cryptococcous neoformans Gsb1 at non-stress and oxidative stress conditions

(Submitter supplied) Purpose: To identify the downstream genes whose expression levels are affected by the deletion of gsb1 under non-stress and oxidative stress conditions, we compared the RNA-seq based transcriptional profiles of wild-type and gsb1 cells. Methods: mRNA profiles of cells grown at non-stress and oxidative stress conditions were generated by RNA-seq using Illumina GAIIx. The sequence reads that passed quality filters were mapped to reference genome and the normalized RPKM values were calculated by CLC Genomics Workbench. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23176 GPL15546
4 Samples
Download data: TXT
Series
Accession:
GSE96543
ID:
200096543
10.

Rad53- and Chk1-Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility

(Submitter supplied) To elucidate the signaling circuitry downstream of Rad53, we compared transcriptome profiles between wild type and rad53Δ mutant strains post radiation exposure using RNAseq analysis. Of total 6,962 genes, 5,087 and 4,768 genes showed statistically different expression levels in the wild type and rad53Δ mutant strains, respectively, post radiation exposure (P-value cutoff of < 0.05; false decrease rate (FDR) cutoff of < 0.05). more...
Organism:
Cryptococcus neoformans var. grubii
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25340
8 Samples
Download data: TXT
Series
Accession:
GSE117227
ID:
200117227
11.

Toc1, Toc2, and Skn7 null mutants treated with Flucytosine

(Submitter supplied) A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomycetous fungal pathogen, Cryptococcus neoformans. In the present study we discovered an APSES-like transcription factor, Msa1 (Mbp1/Swi4-like APSES protein 1), as one of novel flucytosine-responsive genes (total 194 genes) identified through comparative transcriptome analysis of C. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
24 Samples
Download data: GPR
Series
Accession:
GSE30154
ID:
200030154
12.

Functional dissection of the regulatory mechanism of the atypical AP-1-like transcription factor, Yap1, in Cryptococcus neoformans

(Submitter supplied) AP-1 like transcription factors play evolutionarily conserved roles in oxidative stress responses as redox sensors in eukaryotes. In this study, we aim to elucidate the regulatory mechanism of an atypical yeast AP-1 like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans. YAP1 expression was induced not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane destabilizing stresses. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23176
6 Samples
Download data: XLSX
Series
Accession:
GSE136832
ID:
200136832
13.

Unravelling the pathobiological role of the fungal KEOPS complex in Cryptococcus neoformans

(Submitter supplied) The kinase, putative endopeptidase and other peptides of small size (KEOPS) complex plays critical cellular functions in eukaryotes, but its pathobiological roles remains elusive in fungal pathogens. Here we comprehensively analyze the pathobiological functions of the KEOPS complex in fungal meningoencephalitis pathogen Cryptococcus neoformans. The cryptococcal KEOPS complex appears to have a linear arrangement of Pcc1-Kae1-Bud32-Cgi121, supported by physical interaction between Pcc1-Kae1, Kae1-Bud32, and Bud32-Cgi121, but does not have Gon7 ortholog, which is the part of the S. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21073
12 Samples
Download data: XLSX
Series
Accession:
GSE208333
ID:
200208333
14.

Cryptococcus neoformans gene expression in minimal media of wild type, ALL2 mutant, and ALL1ALL2 mutant cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL15151
4 Samples
Download data: GPR
Series
Accession:
GSE74219
ID:
200074219
15.

Cryptococcus neoformans gene expression in minimal media of wild type (WT) and all1all2Δ mutant cells

(Submitter supplied) To examine the comparative transcription profile of WT and all1all2Δ mutant cells in in vitro conditions to determine genes resposible for hyporvirulent phenotype of all1all2Δ mutant cells. Using transcriptional profiling, we determined that many genes involved in amino acid transport were differentially transcribed between the wild type and the all1all2Δ mutant strain. The genes differentially expressed in double mutant of ALL1 ALL2 did not overlap with ALL1 and ALL2 comparative transcriptomes with RC2 (WT).
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL15151
2 Samples
Download data: GPR
Series
Accession:
GSE74218
ID:
200074218
16.

Cryptococcus neoformans gene expression in minimal media of wild type (WT) and ALL2 mutant (all2Δ) cells

(Submitter supplied) To examine the comparative transcription profile of WT and all2Δ mutant cells in in vitro conditions to determine genes responsible for hypervirulent phenotype of all2Δ cells. Using transcriptional profiling, we determined that many genes involved in transport were differentially transcribed between the wild type and the mutant strain. With the help of further experiments we could rule out that ALL2 has a unique function in maintaining the intracellular pH under acidic conditions.
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL15151
2 Samples
Download data: GPR
Series
Accession:
GSE74217
ID:
200074217
17.

WT vs rim101 mutant gene expression under capsule inducing conditions

(Submitter supplied) Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved pH-response regulator in many fungal species. The rim101- mutant strain displays growth defects similar to other fungal species in the presence of alkaline pH, increased salt concentrations, and iron limitation. more...
Organism:
Cryptococcus neoformans var. neoformans; Cryptococcus neoformans var. grubii
Type:
Expression profiling by array
Platform:
GPL4009
1 Sample
Download data: GPR
Series
Accession:
GSE23929
ID:
200023929
18.

Time-course microarray study of Cryptococcus neoformans var. neoformans spore germination

(Submitter supplied) To identify the genome-wide transcriptional changes that occur throughout germination of C. neoformans spores, we conducted a time-course microarray experiment spanning six timepoints to generate a temporal expression pattern for each known gene. Spores were placed in rich medium and allowed to germinate for 10 hours, when they start to replicate as yeast. Each time point was flash frozen in liquid nitrogen and RNA was harvested for each time point at the same time. more...
Organism:
Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platform:
GPL4009
6 Samples
Download data: GPR
Series
Accession:
GSE53912
ID:
200053912

Supplemental Content

db=gds|term=|query=1|qty=6|blobid=MCID_679c0954c83ed746356584d4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center
External link. Please review our privacy policy.