GEO DataSets

(Submitter supplied) Outbred D.melanogaster populations subjected to >300 generations of natural selection on either control, or 12% ethanol, or variable food (2 replicates each) and exposed, as first instar larvae, to either water control or 12% ethanol.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

34 Samples

Download data: CEL, CHP

(Submitter supplied) Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS3072

Platform:

GPL1322

24 Samples

Download data: CEL, CHP

Analysis of alcohol resistant and sensitive strains. Strains generated by artificial selection for alcohol sensitivity over multiple generations. Results provide insight into the molecular basis of alcohol sensitivity.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 gender, 2 other, 3 strain sets

Platform:

GPL1322

Series:

GSE7614

24 Samples

Download data: CEL, CHP

(Submitter supplied) We used RNA-seq to investigate gene expression variation in Malpighian tubules, which have a function analogous to that of human kidneys. In order to characterize population differentiation, we sequenced the Malpighian tubule transcriptomes of flies derived from two populations, one from sub-Saharan Africa (Zimbabwe) and one from Europe (the Netherlands). Males and females were examined separately. Overall, we found a high amount of differential expression between sexes (2,308 genes) and populations (2,474 genes). Although most of the differentially expressed genes were consistent between sexes and populations, there were 615 genes showed sex-biased expression in only one population and 557 genes showed population-biased expression in only one sex.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13304

8 Samples

Download data: TXT

(Submitter supplied) Background: Changes in gene regulation are thought to be crucial for the adaptation of organisms to their environment. Transcriptome analyses can be used to identify candidate genes for ecological adaptation, but can be complicated by variation in gene expression between tissues, sexes, or individuals. Here we use high-throughput RNA sequencing of a single Drosophila melanogaster tissue to detect brain-specific differences in gene expression between the sexes and between two populations, one from the ancestral species range in sub-Saharan Africa and one from the recently colonized species range in Europe. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13304

8 Samples

Download data: TXT

(Submitter supplied) A study evaluating the effect of stress resistance selection of Drosophila melanogaster. Abstract Here, we report a detailed analysis of changes in gene expression in Drosophila melanogaster selected for multiple eological relevant environmental stress resistance traits. We analyzed females from three biological replicates from seven selection regimes and one control regime using whole genome gene expression arrays. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2830

Platform:

GPL72

24 Samples

Download data: CEL

Analysis of several lines each selected for resistance to a different environmental stress factor. Results provide insight into the molecular and genetic mechanisms that promote adaptation to environmental stresses.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, transformed count, 8 strain sets

Platform:

GPL72

Series:

GSE6558

24 Samples

Download data: CEL

(Submitter supplied) Genes with sex-biased expression often show rapid molecular evolution between species. Previous population genetic and comparative genomic studies of Drosophila melanogaster and D. simulans revealed that male-biased genes have especially high rates of adaptive evolution. To test if this is also the case for other lineages within the melanogaster group, we investigated gene expression in D. ananassae, a species that occurs in structured populations in tropical and subtropical regions. more...

Organism:

Drosophila ananassae

Type:

Expression profiling by array

Platform:

GPL9699

12 Samples

Download data

(Submitter supplied) Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent and preventable pediatric disorder. Identifying genetic risk alleles for FASD is impossible in human populations, but the Drosophila genetic model can provide insights. We analyzed changes in genome-wide gene expression in 96 wild-derived inbred fly lines after exposure to alcohol during development. We found extensive sexual dimorphism in the effect of alcohol on gene expression along with effects on adult locomotor activity and sleep. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

384 Samples

Download data: TXT

(Submitter supplied) Differences in the selective pressures experienced by males and females are believed to be ubiquitous in dioecious organisms and are expected to result in the evolution of sexually antagonistic alleles, thereby driving the evolution of sexual dimorphism. Negative genetic correlation for fitness between the sexes has been documented, however, the identity, number and location of loci causing this relationship are unknown. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

120 Samples

Download data: CEL

(Submitter supplied) This RNAseq study has been performed in the framework of a project using experimental evolution to understand the consequences of genetically-based adaptation to juvenile undernutrition for adult gene metabolism. Six "Selected" populations of Drosophila melanogaster had been maintained on a very poor larval diet (3.2 g yeast / liter w/v) for 14 years (about 250 generations). Six "Control" populations of the same origin had been maintained in parallel on the standard diet (12.5 g yeast/liter). more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21306

24 Samples

Download data: TSV, TXT

(Submitter supplied) We performed mRNA-seq of dissected Drosophila mushroom bodies, comparing to whole brain and testis

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9058

4 Samples

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