Similar studies for GEO DataSets (Select 200041237) - GEO DataSets

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Items: 20

Select item 2000412371.

Chip-chip from Candida albicans cells with HMS1-MYC, RTG1-MYC, RTG3-MYC, GFP-ZCF21, GFP-LYS14, GFP-LYS144

(Submitter supplied) The transcription regulators HMS1, RTG1, RTG3, ZCF21, LYS14 and LYS144 play roles in the proliferation of C. albicans in a mammalian host. Chromatin immunoprecipitation (ChIP) of HMS1-MYC, RTG1-MYC, RTG3-MYC, GFP-ZCF21, GFP-LYS14, GFP-LYS144 followed by array hybridization (Agilent) uncovered a network of target genes required for C. albicans to thrive in the host.

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL13696
8 Samples

Download data: GPR

Series

Accession:: GSE41237

ID:: 200041237

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001816552.

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells

(Submitter supplied) We employed RNA-Seq to identify ZCF8-dependent and ZCF8-indepenent transcriptional changes in Candida albicans cells treated with nigericin.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28323
8 Samples

Download data: CSV, TXT

Series

Accession:: GSE181655

ID:: 200181655

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001816533.

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [RNA-seq]

(Submitter supplied) We employed RNA-Seq to identify targets of regulation of the transcription regualtor ZCF8 in nitrogen-starved Candida albicans cells.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28323
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE181653

ID:: 200181653

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Select item 2001816524.

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [ChIP-seq]

(Submitter supplied) We employed ChIP-Seq to identiy direct targets of regulation of the Candida albicans transcription regulator Zcf8p.

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15645
12 Samples

Download data: TXT

Series

Accession:: GSE181652

ID:: 200181652

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Select item 2000305935.

A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans

Type:: Expression profiling by array; Genome binding/occupancy profiling by array

Platforms:: GPL13696 GPL13813
32 Samples

Download data: GPR

Series

Accession:: GSE30593

ID:: 200030593

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Select item 2000305916.

A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis [ChIP_chip]

(Submitter supplied) The mammalian gastrointestinal tract and the bloodstream are highly disparate biological niches, and yet certain commensal-pathogenic microorganisms are able to thrive in both environments. Here, we report the evolution of a unique transcription circuit in the yeast, Candida albicans, which determines its fitness in both host niches. Our comprehensive analysis of the DNA-binding proteins that regulate iron uptake by this organism suggests the evolutionary intercalation of a transcriptional activator called Sef1 between two broadly conserved transcriptional repressors, Sfu1 and Hap43. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by array

Platform:: GPL13696
10 Samples

Download data: GPR

Series

Accession:: GSE30591

ID:: 200030591

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Select item 2000305907.

A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis [Expression Array]

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL13813
22 Samples

Download data: GPR

Series

Accession:: GSE30590

ID:: 200030590

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Select item 2001376558.

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans

(Submitter supplied) Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. This suppleness requires an effective mechanism to reprogram reversibly the primary metabolism in response to oxygen variation. Here, we have uncovered that Snf5, a subunit of SWI/SNF chromatin remodeling complex, is a major transcriptional regulator that links oxygen status to the metabolic capacity of C. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
4 Samples

Download data: TXT

Series

Accession:: GSE137655

ID:: 200137655

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Select item 2000740119.

Ssn6 defines a new level of regulation of white-opaque switching in Candida albicans and is required for the stochasticity of the switch

(Submitter supplied) The human commensal and opportunistic pathogen Candida albicans can switch between two distinct, heritable cell types, named “white” and “opaque,” which differ in morphology, mating abilities, metabolic preferences, and in their interactions with the host immune system. Previous studies revealed a highly interconnected group of transcriptional regulators that control switching between the two cell types. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL13830
21 Samples

Download data: GPR

Series

Accession:: GSE74011

ID:: 200074011

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Select item 20005805410.

Ssn6, a new regulator of white-opaque switching in Candida albicans

(Submitter supplied) The human fungal pathogen Candida albicans can switch between two phenotypic cell types, termed “white” and “opaque.” Both cell types are heritable for many generations, and the switch between the two types occurs epigenetically, that is, without a change in the DNA sequence of the genome. In this work we describe that SSN6, the C. albicans functional homolog of Saccharomyces cerevisiae Cyc8, is a regulator of the white-opaque switch. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL16365
9 Samples

Download data: GPR

Series

Accession:: GSE58054

ID:: 200058054

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Select item 20011743311.

Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies.

(Submitter supplied) Candida albicans is an opportunistic fungal pathogen that can infect oral mucosal surfaces despite being under continuous flow from saliva. Previous studies have shown that under specific conditions C. albicans will form microcolonies that more closely resemble the biofilms formed in vivo than standard in vitro biofilm models. However, very little is known about these microcolonies, particularly genomic differences between these specialized biofilm structures and the traditional in vitro biofilms. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19036
6 Samples

Download data: DIFF

Series

Accession:: GSE117433

ID:: 200117433

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Select item 20001334512.

Expression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 90 min p.i.

(Submitter supplied) Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. more...

Organism:: Candida dubliniensis; Candida albicans

Type:: Expression profiling by array

Platform:: GPL6453
8 Samples

Download data: GPR, TXT

Series

Accession:: GSE13345

ID:: 200013345

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Select item 20001331813.

Expression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 30 min p.i.

Organism:: Candida albicans; Candida dubliniensis

Type:: Expression profiling by array

Platform:: GPL6475
6 Samples

Download data: GPR, TXT

Series

Accession:: GSE13318

ID:: 200013318

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Select item 20014237014.

Genome-wide expression profiling of Candida albicans transcription factor Rme1p

(Submitter supplied) Rme1, a conserved transcription factor among members of the ascomycete lineage, regulates meiosis and pseudohyphal growth in baker’s yeast. The genome of the meiosis-defective fungal pathogen Candida albicans encodes a Rme1 homolog, which we previously mapped within a transcriptional circuitry that controls hyphal growth. To delineate a possible role of Rme1 in C. albicans morphogenesis, we combined genome-wide expression and location analyses of Rme1. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19932
9 Samples

Download data: GPR

Series

Accession:: GSE142370

ID:: 200142370

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Select item 20014215915.

Genome-wide location of Candida albicans transcription factor Rme1p

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL17892
2 Samples

Download data: GPR

Series

Accession:: GSE142159

ID:: 200142159

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Select item 20002842916.

Candida albicans Microarray studies: CAP2 (Wild type) vs. cap2D (Homozygous null mutant)

(Submitter supplied) Transcriptome profiling to identify Cap2/Hap43 regulons in the human fungal pathogen Candida albicans: Wild type vs. cap2D grown in iron-depleted medium

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL4758
4 Samples

Download data: GPR

Series

Accession:: GSE28429

ID:: 200028429

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Select item 20004177117.

Expression of C. albicans genes during GI tract colonization and influence of efg1, efh1 and cph1 mutations

(Submitter supplied) The goals of this study were to identify the Efg1p-regulon during GI tract colonization and to compare C. albicans gene expression during colonization of different organs of the GI tract. Our results identified significant differences in gene expression between cells colonizing the cecum and ileum. In addition, during laboratory growth, efg1- null mutant cells grew to a higher density than WT cells. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
44 Samples

Download data: TXT

Series

Accession:: GSE41771

ID:: 200041771

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Select item 20010539918.

Analysis of Transcript Abundance in white, intermediate, and opaque cell states from WT and EFG1 heterozygotes in Candida albicans

(Submitter supplied) The ability to undergo heritable switching between cell states is well recognized in microbial species. In the human fungal pathogen Candida albicans, cells can stably exist in several alternative states that show differential interactions with the mammalian host. Here, we demonstrate that gene dosage of the master transcription factor, Efg1, controls access to distinct cell states in diploid C. albicans cells. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19036
31 Samples

Download data: CSV

Series

Accession:: GSE105399

ID:: 200105399

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Select item 20014583119.

The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence and plays distinct roles in regulating pathogenic traits

(Submitter supplied) Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen Candida albicans. Biochemical analysis showed that CaRSC comprises 13 subunits and contains two novel non-essential members, which we named Nri1 and Nri2 (Novel RSC Interactors) that are exclusive to the CTG clade of Saccharomycotina. more...