Similar studies for GEO DataSets (Select 200042605) - GEO DataSets

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Items: 20

Select item 2000426051.

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 in pancreas cancer

(Submitter supplied) An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8+ T cells, the mice, like human PDA patients, did not respond to two immunological checkpoint antagonists that promote the function of T cells, α-CTLA-4 and α-PD-L1. Immune control of PDA growth was achieved, however, by depleting carcinoma-associated fibroblasts (CAFs) that express Fibroblast Activation Protein (FAP). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL9250
4 Samples

Download data: TXT

Series

Accession:: GSE42605

ID:: 200042605

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000394382.

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(Submitter supplied) Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human cancers and chronic inflammatory lesions. In mouse models of cancer, they have been shown to be immune suppressive, but studies of their occurrence and function in normal tissues have been limited. With a transgenic mouse line permitting the bioluminescent imaging of FAP(+) cells, we find that they reside in most tissues of the adult mouse. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9250
8 Samples

Download data: CNT, RPKM, TXT

Series

Accession:: GSE39438

ID:: 200039438

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Select item 2001577813.

Cadherin 11 promotes immunosuppression and extracellular matrix deposition to promote growth of pancreatic tumors and resistance to gemcitabine in mice

(Submitter supplied) Background & Aims: Pancreatic ductal adenocarcinomas (PDAC) are characterized by fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated strategies to disrupt interactions among CAFs, the immune system, and cancer cells, focusing on adhesion molecule cadherin 11 (CDH11), which has been associated with other fibrotic disorders and is expressed by activated fibroblasts. Methods: We compared levels of CDH11 mRNA in human pancreatitis and pancreatic cancer tissues and cells, compared with normal pancreas, and measured levels of CDH11 protein in human and mouse pancreatic lesions and normal tissues. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
12 Samples

Download data: TXT

Series

Accession:: GSE157781

ID:: 200157781

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Select item 2002352464.

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and responsiveness to immunotherapy in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL17021
38 Samples

Download data

Series

Accession:: GSE235246

ID:: 200235246

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Select item 2002352445.

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [hPDAC]

(Submitter supplied) Senescent cells appear within tumors and their stroma, exerting complex pro- and anti-tumorigenic functions. The effects of senescent tumor stromal cells are mostly unknown, as is the potential for targeting such senescent cells for improved therapy. Here we uncover the presence of a senescent subset of cancer-associated fibroblasts (CAFs) within pancreatic adenocarcinomas and in premalignant pancreatic lesions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TXT

Series

Accession:: GSE235244

ID:: 200235244

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002352426.

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [Kras_p53]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: TXT

Series

Accession:: GSE235242

ID:: 200235242

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Select item 2002352337.

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [Cultured_Human_Mouse]

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
16 Samples

Download data: TXT

Series

Accession:: GSE235233

ID:: 200235233

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Select item 2001786778.

The WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE178677

ID:: 200178677

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Select item 2001786769.

The WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape [RNA-seq]

(Submitter supplied) Two orthotopic pancreatic tumor mouse models were used for ChIP-Seq and RNA-Seq to identify genome-wide dysfunction of H3K4me3 and gene expression. Mouse pancreatic tumors have a genome-wide increase in H3K4me3 deposition as compared to normal pancreas. Osteopontin (OPN) and its receptor CD44 were identified being up-regulated in pancreatic tumors by their promoter H3K4me3 deposition. OPN protein is increased in both tumor cells and tumor-infiltrating immune cells in human pancreatic carcinoma and is inversely correlated with pancreatic cancer patient survival. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE178676

ID:: 200178676

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Select item 20017867510.

The WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape [ChIP-seq]

(Submitter supplied) Total RNA was isolated from normal C57BL/6 mouse pancreas, PANC02-H7, and UN-KC-6141 tumors from tumor-bearing mice. The RNA was used for RNA-Seq. The gene expression profiles between normal mouse pancreas and orthotopic pancreatic tumors were compared, and differentially expressed genes were identified.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BIGWIG

Series

Accession:: GSE178675

ID:: 200178675

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Select item 20015735311.

Expression data from human pancreatic ductal adenocarcinomas by stroma types

(Submitter supplied) Pancreatic cancer is characterized by abundant desmoplastic stroma. Despite numerous theoretical and experimental efforts, therapeutic approaches targeting pancreatic cancer stroma have been largely unsuccessful, highlighting the need for more comprehensive assessment of inter- and intratumoral stromal heterogeneity in a large series of clinical tumors. Quantitative computation of FAP-dominant fibroblasts, ACTA2-dominant fibroblasts, and intratumoral collagen in whole-tissue sections from 215 treatment-naïve pancreatic cancers allowed us to identify three distinct stroma types (FAP-dominant fibroblast-rich stroma [F-stroma], ACTA2-dominant fibroblast-rich stroma [A-stroma], and collgen-rich stroma [C-stroma]), which were differentially associated with patient outcomes, molecular characteristics and the immunosuppressive tumor microenvironment. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
20 Samples

Download data: CEL

Series

Accession:: GSE157353

ID:: 200157353

Select item 20007523312.

Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

(Submitter supplied) Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a uniquely immunosuppressive tumor microenvironment (TME). Critical obstacles to immunotherapy in PDAC tumors include a high number of tumor-associated immunosuppressive cells and a uniquely desmoplastic stroma that functions as a barrier to T cell infiltration. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
12 Samples

Download data: TXT

Series

Accession:: GSE75233

ID:: 200075233

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019881513.

Functional heterogeneity of cancer-associated fibroblasts in pancreatic cancer

(Submitter supplied) Single-cell RNA-sequencing analyses were performed on unfractionated live cell mixtures or sorted fibroblasts from pancreatic tumors of KPC;YFP mice, so as to investigate the functional heterogeneity of cancer-associated fibroblasts in early-stage and late-stage tumors.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
14 Samples

Download data: CSV

Series

Accession:: GSE198815

ID:: 200198815

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Select item 20019302714.

The immunological comparison of control PDA tumors and Krt19-edited PDA tumors

(Submitter supplied) Our studies indicate that cancer cells of carcinomas are coated with CXCL12 chemokine in covalent conjugation with keratin-19 (KRT19). Murine pancreatic ductal adenocarcinomas (PDA) formed with Krt19-edited cancer cells lack the CXCL12-coating and are infiltrated with T cells, compared to tumors formed with control sgScramble PDA cells. To probe the immunological role of this CXCL12-coating thoroughly, bulk RNA sequencing of subcutaneous (s/c) murine sgScramble PDA tumors and Krt19-edited PDA tumors were conducted.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: TXT

Series

Accession:: GSE193027

ID:: 200193027

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Select item 20019285315.

The immunological comparison of control PDA tumors and Krt19-edited PDA tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: TXT

Series

Accession:: GSE192853

ID:: 200192853

PubMed Full text in PMC Similar studies

Select item 20027085816.

Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer

(Submitter supplied) Here, using the mouse KRT19-deficient (sgKRT19-edited) PDA model, we find that intratumoral accumulation of natural killer T (NKT) cells are required to establish an immunologically active TME. Mechanistically, intratumoral NKT cells facilitate type I interferon (IFN) production to initiate an anti-tumor adaptive immune response, and orchestrate the intratumoral infiltration of T cells, dendritic cells, natural killer cells and myeloid-derived suppressor cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE270858

ID:: 200270858

PubMed Full text in PMC Similar studies

Select item 20017605717.

In vitro fibroblast gene expression - tissue comparison

(Submitter supplied) Gene expression of in vitro CD105pos and CD105neg pancreatic fibroblasts (PaFs) and liver fibroblasts (LiFs)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
16 Samples

Download data: TXT

Series

Accession:: GSE176057

ID:: 200176057

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017605618.

In vivo co-transplant gene expression

(Submitter supplied) Gene expression of bulk subcutaneous tumors growing from either KPC PDA tumor cells co-transplanted with CD105pos Pancreatic Fibroblasts (PaFs) or CD105neg PaFs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE176056

ID:: 200176056

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015739119.

Gene expression profiles of in vitro CD105pos and CD105neg pancreatic fibroblasts (PaFs) after stimulation with various recombinant proteins

(Submitter supplied) CD105pos and CD105neg PaFs were isolated from B6 murine pancreas, subjected to in vitro stimulation for 6h and gene expression profiles measured