Similar studies for GEO DataSets (Select 200047967) - GEO DataSets

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Items: 20

Select item 2000479671.

Cooperation of estrogen and oocytes on gene expression in mouse cumulus cells

(Submitter supplied) Oocyte-derived paracrine factors and estrogens cooperate to regulate the function and development of mouse cumulus cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE47967

ID:: 200047967

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000558452.

Analysis of transcriptomic diversitification of developing cumulus and mural granulosa cells in mouse ovarian follicles

(Submitter supplied) Cumulus cells and mural granulosa cells (MGCs) are spatially and functionally distinct cell types in antral follicles: cumulus cells contact the oocyte and most MGCs contact the basal lamina. For transcriptomic analyses, both cell types were collected from small and large antral follicles, before and after stimulation of immature mice with eCG, respectively. Both cell types underwent dramatic transcriptomic changes and the differences between them became greater with follicular growth. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18416
12 Samples

Download data: CEL

Series

Accession:: GSE55845

ID:: 200055845

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Select item 2000072253.

Identification and characterization of the changed transcripts in cumulus cells of Bmp15-/- and Bmp15-/-Gdf9+/--DM mice.

(Submitter supplied) Mouse oocytes control cumulus cell metabolic processes that are deficient in the oocytes themselves and this delegation is necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular development. The effect of these factors on cumulus cell function before the preovulatory surge of luteinizing hormone (LH) was assessed by analysis of the transcriptomes of cumulus cells from wildtype (WT), Bmp15-/-, and Bmp15-/- Gdf9+/- double mutant (DM) mice using microarray analysis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE7225

ID:: 200007225

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Select item 2000185594.

The differential transcriptome and ontology profiles of mural and cumulus granulosa cells in stimulated antral follicles

(Submitter supplied) Communication between various ovarian cell types is a prerequisite for folliculogenesis and ovulation. In antral follicles granulosa cells divide into two distinct populations of mural (MGC) and cumulus granulosa cells (CGC), enveloping the antrum and surrounding the oocyte, respectively. IVF offers a good opportunity for analysing their functional properties since granulosa cells can be retrieved during the puncturing procedure of stimulated follicles. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
38 Samples

Download data: CEL

Series

Accession:: GSE18559

ID:: 200018559

Select item 2002353465.

Dynamic changes in gene expression of growing nonhuman primate antral follicles

(Submitter supplied) Ovaries from adult female rhesus monkeys were obtained on a serendipitous basis from animals going to necropsy for various reasons, none of which would be expected to impact ovarian function. The follicle size categories to be collected were determined based on the fact that in rhesus monkeys, follicles that produce mature oocytes are generally larger than 1mm and in each pair of naturally cycling ovaries there were generally fewer than five follicles in this category. more...

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19129
35 Samples

Download data: TSV

Series

Accession:: GSE235346

ID:: 200235346

PubMed

Select item 2000798866.

Bovine cumulus cells transcriptome in relation with oocyte chromatin configuration of the germinal vesicle

(Submitter supplied) Gene expression analysis in cc from COCs with different chromatin configuration (GV0-3)

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL13226
12 Samples

Download data: TXT

Series

Accession:: GSE79886

ID:: 200079886

Select item 2000383877.

Rhesus monkey cumulus cells revert to a mural granulosa cell state following an ovulatory stimulus

(Submitter supplied) Follicular somatic cells (mural granulosa cells and cumulus cells) and the oocyte communicate through paracrine interactions and through direct gap junctions between oocyte and cumulus cells. Considering that mural and cumulus cells arise through a common developmental pathway and that their differentiation is essential to reproductive success, understanding how these cells differ is a key aspect to understanding their critical functions. more...

Organism:: Macaca mulatta

Type:: Expression profiling by array

Platform:: GPL3535
8 Samples

Download data: CEL

Series

Accession:: GSE38387

ID:: 200038387

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Select item 2000648588.

Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides

(Submitter supplied) Background: The gonadotropin-induced resumption of oocyte meiosis in preovulatory follicles is preceded by expression of epidermal growth factor (EGF)-like peptides, amphiregulin (AREG) and epiregulin (EREG), in mural granulosa and cumulus cells. Both the gonadotropins and the EGF-like peptides possess the capacity to stimulate resumption of oocyte meiosis in vitro via activation of a broad signaling network in cumulus cells. more...

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL7435
9 Samples

Download data: TXT

Series

Accession:: GSE64858

ID:: 200064858

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Select item 2000395899.

Gene expression in bovine ovarian follicle granulosa

(Submitter supplied) Granulosa cells mature and die as ovarian follicles enlarge and die (undergo atresia) under the influence of hormones and intrafollicular factors. Later in follicular development, a fluid-filled antrum is formed, a process which is accompanied by a high rate of atresia. These small antral follicles (5 mm or less in diameter in the cow) contain granulosa of 2 different phenotypes, rounded or columnar, whereas follicles larger than 5 mm have the rounded phenotype only. more...

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL2112
19 Samples

Download data: CEL

Series

Accession:: GSE39589

ID:: 200039589

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Select item 20009967810.

Functional signaling and gene regulatory networks between the oocyte and the surrounding cumulus cells

(Submitter supplied) The maturation of an oocyte, the female gamete, during folliculogenesis is highly dependent on the molecular interaction with the somatic cells. Here we generated transcriptome data of single oocytes and the surrounding cumulus cells from antral follicles, and developed an analytical framework to unveil their inter-cellular communication. We identified hundreds of ligand-receptors pairs that can transduce paracrine signaling between oocyte and cumulus. more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19172
48 Samples

Download data: TXT

Series

Accession:: GSE99678

ID:: 200099678

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010677611.

Differential miRNA profiles in cumulus and mural granulosa cells from human pre-ovulatory follicles

(Submitter supplied) Small RNA seq analysis identified several hundreds of miRNAs being expressed in MGC and CC. 53 miRNAs were differentially regulated

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: XLSX

Series

Accession:: GSE106776

ID:: 200106776

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Select item 20017634412.

Next Generation Sequencing of Oocyte and Associated Cumulus Cells Pools from Preovualtory Follicles in Bovine

(Submitter supplied) Purpose: Preovualtory follicle diameter influences embryo quality in beef cattle that rely on a gonadotropin releasing hormone (GnRH) injection to induce the preovualtory gonadotropin surge and subsequent ovualtion. The goals of this study are to compare transcriptome profiles of pools of four oocytes or associated cumulus cells collected from small (≤11.7mm) and large follicles (≥12.7 mm) exposed to a GnRH-induced gonadotropin surge and follicles (11.7-14.0 mm) exposed to an endogenous gonadotropin surge (spontaneous follicles). more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15749
33 Samples

Download data: TXT

Series

Accession:: GSE176344

ID:: 200176344

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012518913.

Granulosa cells of ovarian antral follicles exhibit distinct follicle size-related processes

(Submitter supplied) Antral follicle size might be a valuable additive predictive marker for IVF outcome. However, while some studies show positive relations between follicle size and reproductive outcome, others have not been successful in establishing this relation. To better understand consequences of antral follicle size for reproductive outcome, we aimed to obtain insight in follicle size-related granulosa cell processes, as granulosa cells play an essential role in follicular development via the production of growth factors, steroids and metabolic intermediates, needed for follicular growth and oocyte development. more...

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL15007
44 Samples

Download data: TXT

Series

Accession:: GSE125189

ID:: 200125189

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Select item 20008157914.

Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence.

(Submitter supplied) RNA sequencing profiling of cumulus cells revealed that the follicles of older women have a compromised environment with hypoxic stress being the main contributor to age-related oocyte quality decay.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
20 Samples

Download data: CSV

Series

Accession:: GSE81579

ID:: 200081579

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Select item 20008025515.

Comparison of transcriptomes of mouse cumulus cells collected from mice before and after 6-h of hCG priming.

(Submitter supplied) We sought to identify genes that are regulated by the ovulatory signals in mouse cumulus cells. We compared the transcriptomes between cumulus cells colected from mice before (hCG-0h) and after 6 h (hCG-6h) of hCG injection.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE80255

ID:: 200080255

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Select item 20007986216.

Comparison of transcriptomes between DMSO-5uM and Torin1-5uM treated mouse cumulus-oocyte complexes cultured in vitro for 14h

(Submitter supplied) We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcriptomes between DMSO- and Torin 1- treated cumulus-oocyte complexes.