GEO DataSets

(Submitter supplied) Skeletal muscle adapts to exercise training of various modes, intensities and durations with a programmed gene expression response. This study dissects the independent and combined effects of exercise mode, intensity and duration to identify which exercise has the most positive effects on skeletal muscle health. Full details on exercise groups can be found in: Kraus et al Med Sci Sports Exerc. 2001 Oct;33(10):1774-84 and Bateman et al Am J Cardiol. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

114 Samples

Download data: CEL, CHP

(Submitter supplied) Microarray analysis was performed with RNA isolated from vastus lateralis muscle biopsies of lean/overweight subjects following 18 days of aerobic exercise training. Samples from lean active individuals were also included. Exercise training led to robust changes in trained muscle. The lean active group profile was distinct from the pre-exercise samples. These results help define the molecular changes associated with aerobic training and contrast with an active phenotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

24 Samples

Download data: IDAT, TXT

(Submitter supplied) The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized for vastus lateralis gene expression profiles. Si was determined via intravenous glucose tolerance test pre- and post-training. Pearson product-moment correlation coefficients determined relationships between a) baseline and b) training-induced changes in gene expression and Si after training.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

84 Samples

Download data: IDAT, TXT

(Submitter supplied) Skeletal muscle mitochondrial dysfunction is secondary to T2DM and can be improved by long-term regular exercise training Mitochondrial dysfunction has long been implicated to play a causative role in development of type 2 diabetes (T2DM). However, a growing number of recent studies provide data that mitochondrial dysfunction is a consequence of T2DM development. The aim of our study is to clarify in further detail the causal role of mitochondrial dysfunction in T2DM by a comprehensive ex vivo analysis of mitochondrial function combined with global gene expression analysis in muscle of pre-diabetic newly diagnosed untreated T2DM subjects and long-standing insulin treated T2DM subjects compared with age- and BMI-matched controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3880

Platform:

GPL570

42 Samples

Download data: CEL

Analysis of skeletal muscle biopsies from insulin-treated type 2 diabetes (T2D) subjects before/after exercise training, pre-diabetics and healthy controls. Results provide insight into the molecular basis of T2D, the role of mitochondrial dysfunction, and the effects of prolonged exercise training.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 34 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE19420

42 Samples

Download data: CEL

(Submitter supplied) STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the “high” exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and after 9 months of aerobic training (24 hrs post-last bout, 96 hrs post last bout, and 336h (14 days) de-training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS915

Platforms:

GPL96 GPL8300

32 Samples

Download data: CEL

Analysis of skeletal muscle from overweight males with metabolic syndrome. Individuals subjected to chronic exercise training. Muscles examined prior to training, and after 1 and 14 days of recovery following 9 months training. Provides insight into effects of exercise intervention.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 time sets

Platform:

GPL8300

Series:

GSE1295

8 Samples

Download data: CEL

(Submitter supplied) The participants performed an 8-week supervised aerobic endurance exercise intervention program. Biopsies of both adipose tissue and skeletal muscle were collected at associated timepoints and a matched analysis was performed. This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

151 Samples

Download data: CEL

(Submitter supplied) The participants performed an 8-week supervised aerobic endurance exercise intervention program. Biopsies of both adipose tissue and skeletal muscle were collected at associated timepoints and a matched analysis was performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

54 Samples

Download data: CEL

(Submitter supplied) The participants performed an 8-week supervised aerobic endurance exercise intervention program. Biopsies of both adipose tissue and skeletal muscle were collected at associated timepoints and a matched analysis was performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

48 Samples

Download data: CEL

(Submitter supplied) The participants performed an 8-week supervised aerobic endurance exercise intervention program. Biopsies of both adipose tissue and skeletal muscle were collected at associated timepoints and a matched analysis was performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

49 Samples

Download data: CEL