GEO DataSets

(Submitter supplied) We have previously showed that whey protein hydrolysate (WPH) causes a greater increase in muscle protein synthesis than an identical composition of amino acids mixture does. The present study was conducted to investigate a comparative effect of WPH on gene expression. Male Sprague-Dawley rats subjected to a 2-h swimming exercise were administered either a carbohydrate-amino acid diet or a carbohydrate-WPH diet immediately after exercise. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5390

Platform:

GPL1355

8 Samples

Download data: CEL

Analysis of epitrochlearis muscle from males exercised for 2hr then fed a whey protein hydrolysate (WPH) diet or a control diet with an identical amino acid composition (AAM). Results provide insight into the molecular basis of the greater post-exercise muscle protein synthesis in the WPH group.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL1355

Series:

GSE49486

8 Samples

Download data: CEL

(Submitter supplied) We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet), soy protein isolate (SPI), and whey protein hydrolysate (WPH) diets were determined. We identified 31 induced and 49 repressed genes in the proximal colons of the SPI-fed group and 44 induced and 119 repressed genes in the proximal colons of the WPH-fed group, relative to CAS. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2468

Platform:

GPL85

9 Samples

Download data: CEL, EXP

Analysis of colons of soy or whey protein fed Sprague Dawley males 40 weeks after azoxymethane (AOM) injection to induce tumor formation. Lifetime consumption of soy or whey proteins reduces the incidence of AOM-induced colon tumors in rats.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL85

Series:

GSE6102

9 Samples

Download data: CEL, EXP

(Submitter supplied) Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of high-intensity cycling then ingested either 70/15/180/30g protein/leucine/carbohydrate/fat (15LEU), 23/5/180/30g (5LEU) or 0/0/274/30g (CON) beverages during the first 90 min of a 240-min recovery period. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

72 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) Dietary collagen hydrolysate has been conjectured to improve skin barrier function. To investigate the effect of long-term collagen hydrolysate administration on the skin, we evaluated stratum corneum water content and skin elasticity in intrinsic aged mice. Female 9-week-old hairless mice were fed a control diet, or a collagen hydrolysate-containing diet, for 12 weeks. The stratum corneum water content and skin elasticity were sequentially decreased by chronological aging in control mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) Dietary collagen hydrolysate has been conjectured to improve skin barrier function. To investigate the effect of long-term collagen hydrolysate administration on the skin, we evaluated stratum corneum water content and skin elasticity in intrinsic aged mice. Female 9-week-old hairless mice were fed a control diet, or a collagen hydrolysate-containing diet, for 12 weeks. The stratum corneum water content and skin elasticity were sequentially decreased by chronological aging in control mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) The objective of this work was to identify genes with a variable expression profile during the course of a skeletal muscle degeneration and regeneration damage in pig. Using cDNA microarrays and repeated measurements performed in the same ten piglets, the expression profile of 1651 genes was investigated at 0, 6 and 48 hours, then 7 and 21 days after the induction of a local iatrogenic muscle damage. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL2731

90 Samples

Download data

(Submitter supplied) Skeletal muscles are a diverse family of highly specialized tissues that perform a wide array of physiological activities and maintain whole-body glucose metabolism and energy homeostasis. Functional diversity is a distinctive feature of muscle tissues, which demonstrate remarkable variability in their speed of contraction, metabolic profile, resistance to fatigue, and regenerative capacity. Unsurprisingly, many disorders of skeletal muscle afflict a remarkably specific subset of tissues, including muscular dystrophies, cancer cachexia, aging sarcopenia, and amyotrophic lateral sclerosis. more...

Organism:

Rattus norvegicus; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL14844 GPL13112

126 Samples

Download data: BED, TXT

(Submitter supplied) Aldosterone is known to have a number of direct adverse effects on the heart, including fibrosis and myocardial inflammation. However, genetic mechanisms of aldosterone action on the heart remain unclear. This experiment investigated of temporal changes in gene expression profile of the whole heart induced by acute administration of a physiologic dose of aldosterone in the mouse. mRNA levels of 34,000 known mouse genes were measured at eight time points after aldosterone administration using oligonucleotide microarrays and compared to those of the control animals who underwent a sham injection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1303

Platform:

GPL1261

15 Samples

Download data: CEL, EXP

Analysis of heart from C57BL/6 males injected with 10 ug/kg aldosterone. Hearts examined at various time points up to 12 hours after injection. Results provide insight into the molecular mechanisms underlying the adverse effects of aldosterone on the heart.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 8 time sets

Platform:

GPL1261

Series:

GSE3440

15 Samples

Download data: CEL, EXP

(Submitter supplied) The time course of wound healing or the estimation of wound age is one of the most important research subjects in forensic pathology. In this study, we obtained microarray data of incision injury samples of mouse skeletal muscle at 3 different time points post-injury (6, 12, and 24 h). To visualize the time course fluctuation in gene expression on a plot, and to examine large-scale data using various analytical methods, correspondence analysis (CA) was carried out on microarray data that was converted to a matrix (data type is fold change (FC) values) consisting of data of each time point (columns) by each gene (rows) as variables. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

16 Samples

Download data: TXT