GEO DataSets

(Submitter supplied) Gene expression in wild-type and p38a-knockout keratinocytes were compared. Keratinocytes were isolated from newborn mice, and left unirradiated (0 h) and irradiated (4 h) with ultraviolet-B (UVB). C57BL/6 wild-type mice, and keratinocyte-specific p38a-knockout mice on a C57BL/6 background were used for isolation of primary keratinocytes.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5335

Platform:

GPL1261

4 Samples

Download data: CEL, CHP

Analysis of p38-alpha deficient keratinocytes exposed to ultraviolet-B (UVB) for 4 hours in vitro. p38-alpha is a mitogen-activated protein kinase. Inflammation underlies UVB's various detrimental effects. Results provide insight into the role of p38-alpha in UVB-induced inflammation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE51206

4 Samples

Download data: CEL, CHP

(Submitter supplied) Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory responses in autoimmunity, but its role in the sexual dimorphism in MS or MS models remains unexplored. Methods: Toward this end, we used experimental autoimmune encephalomyelitis (EAE), the principal animal model of MS, combined with pharmacologic and genetic inhibition of p38 MAPK activity and transcriptomic analyses. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL