GEO DataSets

(Submitter supplied) Despite intense efforts the molecular understanding of this clinically important extra pulmonary manifestation is still limited. Cigarette smoking is the main risk factor for developing COPD and therefore animal chronic smoking models have been proposed for mechanistic studies and biomarker discovery. The overarching aim of our study was to assess whether GP hindlimb muscles (both oxidative and glycolytic) show a transcriptional response to these exposures, and whether such gene signatures can be correlated to the expression of lung secreted proteins.

Organism:

Cavia porcellus

Type:

Expression profiling by array

Platform:

GPL17826

45 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Cavia porcellus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL17296 GPL17826

49 Samples

Download data: TXT

(Submitter supplied) In 2008 the GP genome was sequenced to a depth of ~7X full coverage, and last updated in 2010. However, because of the lack of cDNA and protein resources the GP genome is at present poorly annotated. Thus, in order to address this issue we performed an in-depth mRNA sequencing of the lung and skeletal muscles transcriptomes and used this to annotate the available GP genome for transcribed sequences. more...

Organism:

Cavia porcellus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17296

4 Samples

Download data: TXT

(Submitter supplied) Study the training exercise effects in chronic obstructive pulmonary disease (COPD) patients and aged-matched healthy individuals. Skeletal muscle biopsies from 9 stable COPD patients with normal fat free mass index (FFMI, 21Kg/m2) (COPDN), 6 COPD patients with low FFMI (16Kg/m2) (COPL), and 12 healthy sedentary subjects (FFMI 21Kg/m2) before and after 8 weeks of a supervised endurance exercise program were analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4906

Platform:

GPL570

54 Samples

Download data: CEL

Analysis of muscle from chronic obstructive pulmonary disease (COPD) patients before and after 8 weeks of exercise training. Skeletal muscle dysfunction and muscle wasting are hallmark systemic effects of COPD. Results provide insight into molecular mechanisms underlying COPD muscle degeneration.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 27 individual, 3 other, 2 protocol sets

Platform:

GPL570

Series:

GSE27536

54 Samples

Download data: CEL

(Submitter supplied) Although cigarette smoke (CS) is the primary risk factor for COPD, the underlying molecular mechanisms for the significant variability in developing COPD in response to CS are incompletely understood. We performed lung gene expression profiling of two different wild-type murine strains (C57BL/6J, NZW/LacJ) and two genetic models with mutations in COPD GWAS genes (HHIP, FAM13A) after 6 months of chronic CS exposure and compared the results to human COPD lung tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

109 Samples

Download data: TXT

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality, is primarily caused by prolonged exposures to cigarette smoke (CS) and the disease may persist or progress even after smoking cessation. To provide novel insight the mechanisms of COPD development we investigated temporal patterns of lung transcriptome expression in response to chronic CS exposure that also persist following CS cessation, using next generation sequencing techniques. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

62 Samples

Download data: CSV, TXT