Similar studies for GEO DataSets (Select 200054467) - GEO DataSets

Select item 2000544671.

Determination of prognosis in metastatic melanoma through integration of clinico-pathologic, mutation, mRNA, microRNA, and protein information

(Submitter supplied) In patients with metastatic melanoma, the identification and validation of accurate prognostic biomarkers will assist rational treatment planning. Studies based on "-omics" technologies have focussed on a single high-throughput data type such as gene or microRNA transcripts. Occasionally, these features were evaluated in conjunction with limited clinico-pathologic data. With the increased availability of multiple data types, there is a pressing need to tease apart which of these sources contain the most valuable prognostic information. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
79 Samples

Download data: TXT

Series

Accession:: GSE54467

ID:: 200054467

Select item 2000593342.

microRNA expression profiling and its integration with mRNA in metastatic melanoma reveal associations with BRAF mutation status and patient prognosis

(Submitter supplied) Objectives/experimental design

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
74 Samples

Download data: TXT

Series

Accession:: GSE59334

ID:: 200059334

Select item 2000193873.

MicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma

(Submitter supplied) In order to improve our understanding of microRNA (miRNA) deregulation in melanoma development and possible consequences for patient survival, miRNA expression profiles were determined, using an array based approach, in melanoma tumors, melanoma cell lines and normal melanocytes. Differentially expressed miRNAs were evaluated in relation to clinical characteristics, patient prognosis in terms of melanoma-specific survival, and mutational status for BRAF and NRAS.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL9081
40 Samples

Download data: TXT

Series

Accession:: GSE19387

ID:: 200019387

Select item 2000531184.

BRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma

(Submitter supplied) Prediction of outcome for melanoma patients with surgically-resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinicopathologic assessment of fresh-frozen macroscopic nodal metastases and the preceding primary melanoma, somatic mutation profiling and gene expression profiling to identify determinants of outcome in 79 melanoma patients. In addition to disease stage <II at initial presentation, the following clinical and pathologic factors were independent predictors of improved outcome (ORs for survival >4yr, 90%CI): presence of a nodular component in the primary melanoma (6.8, 0.6-76.0), and small cell size (11.1, 0.8-100.0) or low pigmentation (3.0, 0.8-100.0) in the nodal metastases. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
79 Samples

Download data: TXT

Series

Accession:: GSE53118

ID:: 200053118

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