Similar studies for GEO DataSets (Select 200055156) - GEO DataSets

Select item 2000551561.

Rif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Saccharomyces cerevisiae

Type:: Other

Platforms:: GPL14887 GPL13821
34 Samples

Download data: PAIR

Series

Accession:: GSE55156

ID:: 200055156

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000551552.

Rif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [ChIP-Seq]

(Submitter supplied) Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-phase. This regulation is thought to involve chromatin structure and organization into timing domains with differential ability to recruit limiting replication factors. more...

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL13821
4 Samples

Download data: TXT

Series

Accession:: GSE55155

ID:: 200055155

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000551303.

Rif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [array]

(Submitter supplied) Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-phase. This regulation is thought to involve chromatin structure and organization into timing domains with differential ability to recruit limiting replication factors. more...

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL14887
30 Samples

Download data: PAIR

Series

Accession:: GSE55130

ID:: 200055130

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Select item 2000979534.

Rif1 Binding and Control of Chromosome-Internal DNA Replication Origins Is Limited by Telomere sequestration

(Submitter supplied) The budding yeast telomere binding protein Rif1 (Rap1-interacting factor 1) plays an evolutionarily conserved role in the control of DNA replication timing, which operates through an interaction with the PP1 phosphatase. Rif1-PP1 has been proposed to inhibit origin firing by reversing the phosphorylation of key targets involved in replication initiation. However, it is not yet known if Rif1 binds directly to the replication origins that it controls. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL17342
40 Samples

Download data: BIGWIG, BW

Series

Accession:: GSE97953

ID:: 200097953

PubMed Similar studies SRA Run Selector

Select item 2001092415.

Rif1 acts through Protein Phosphatase 1 and independent of replication timing to suppresses telomere extension in budding yeast

(Submitter supplied) The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast S. cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore we investigated whether Rif1 controls telomere length by targeting PP1 activity. We find that a Rif1 mutant that cannot interact with PP1 causes a long-telomere phenotype, similar to that of rif1∆ cells. more...

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL19756
6 Samples

Download data: WIG

Series

Accession:: GSE109241

ID:: 200109241

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Select item 2000343696.

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(Submitter supplied) One of the long-standing questions in eukaryotic DNA replication is the mechanisms that determine where and when a particular segment of the genome is replicated. Cdc7/Hsk1 is a conserved kinase required for initiation of DNA replication, and may affect the site selection and timing of origin firing. We identified rif1∆, a null mutant of rif1+, a conserved telomere binding factor, as an efficient bypass mutant of fission yeast hsk1. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL7715
7 Samples

Download data: CEL, TXT

Series

Accession:: GSE34369

ID:: 200034369

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Select item 2002298857.

RIF1 regulates replication origin activity and early replication timing in B cells [RNA-seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
15 Samples

Download data: TXT

Series

Accession:: GSE229885

ID:: 200229885

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Select item 2002288808.

RIF1 regulates early replication timing in murine B cells.

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating murine B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin and promotes early replication, but plays a minor role in regulating replication origin activity, gene expression and genome organization in B cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

4 related Platforms
69 Samples

Download data: BEDGRAPH, BW, HIC, MCOOL

Series

Accession:: GSE228880

ID:: 200228880

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Select item 2002288799.

RIF1 regulates replication origin activity and early replication timing in B cells [SNS-seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Other

Platforms:: GPL17021 GPL24247
8 Samples

Download data: BED, TSV

Series

Accession:: GSE228879

ID:: 200228879

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Select item 20022887810.

RIF1 regulates replication origin activity and early replication timing in B cells [Repli-Seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL30172
36 Samples

Download data: BED, BEDGRAPH, BW

Series

Accession:: GSE228878

ID:: 200228878

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Select item 20022887711.

RIF1 regulates replication origin activity and early replication timing in B cells [PRO-seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21626
4 Samples

Download data: BW

Series

Accession:: GSE228877

ID:: 200228877

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Select item 20022887612.

RIF1 regulates replication origin activity and early replication timing in B cells [HI-C]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
2 Samples

Download data: BEDGRAPH, BW, HIC, MCOOL

Series

Accession:: GSE228876

ID:: 200228876

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Select item 20022887513.

RIF1 regulates replication origin activity and early replication timing in B cells [ChIP-seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: BED, BW

Series

Accession:: GSE228875

ID:: 200228875

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Select item 20007105214.

Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by array

Platforms:: GPL14887 GPL19756
70 Samples

Download data: PAIR

Series

Accession:: GSE71052

ID:: 200071052

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007105115.

Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase (ChIP)

(Submitter supplied) The S. cerevisiae Forkhead Box (FOX) proteins, Fkh1 and Fkh2, regulate diverse cellular processes including transcription, long-range DNA interactions during homologous recombination, and replication origin timing and long-range origin clustering. As stimulators of early origin activation, we hypothesized that Fkh1 and Fkh2 abundance limits the rate of origin activation genome-wide. Existing methods, however, were not well suited to quantitative, genome-wide measurements of origin firing between strains and conditions. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by array

Platform:: GPL14887
6 Samples

Download data: PAIR

Series

Accession:: GSE71051

ID:: 200071051

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Select item 20007105016.

Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase (BrdU)

(Submitter supplied) The S. cerevisiae Forkhead Box (FOX) proteins, Fkh1 and Fkh2, regulate diverse cellular processes including transcription, long-range DNA interactions during homologous recombination, and replication origin timing and long-range origin clustering. As stimulators of early origin activation, we hypothesized that Fkh1 and Fkh2 abundance limits the rate of origin activation genome-wide. Existing methods, however, were not well suited to quantitative, genome-wide measurements of origin firing between strains and conditions. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19756
64 Samples

Download data: TXT

Series

Accession:: GSE71050

ID:: 200071050

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014824417.

Nuclear organization and replication timing are coupled through RIF1-PP1 interaction

(Submitter supplied) Three-dimensional genome organisation and replication timing are known to be correlated, however, it remains unknown whether nuclear architecture overall plays an instructive role in the replication-timing program and, if so, how. Here we demonstrate that RIF1 is a molecular hub that co-regulates both processes. Both nuclear organisation and replication timing depend upon the interaction between RIF1 and PP1. more...

Organism:: Mus musculus

Type:: Other

Platforms:: GPL19057 GPL21626
13 Samples

Download data: MCOOL

Series

Accession:: GSE148244

ID:: 200148244

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003724418.

S-phase time-course of Lachancea kluyveri cells

(Submitter supplied) Haploid cells of Lachancea kluyveri were arrested in G1 phase using Saccharomices cerevisiae alpha factor. After, release in a new media, cells go synchronously through S-phase. One sample is taken every five minutes. Microarrays are used to monitor the change of DNA copy number from 1 to 2, all along the genome during S-phase.

Organism:: Lachancea kluyveri

Type:: Genome variation profiling by genome tiling array

Platform:: GPL15421
24 Samples

Download data: GPR

Series

Accession:: GSE37244

ID:: 200037244

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Select item 20020034919.

Rpd3 regulates single-copy origins independently of the rDNA array by opposing origin stimulation by Fkh1 [BrdU-IP-seq]

(Submitter supplied) The replication of eukaryotic genomes is highly regulated to ensure faithful transmission of all genetic information through cell divisions. In addition to stringent control of origin initiation by cell cycle controls and DNA damage checkpoints, spatial and temporal control of origins serves to stage and balance replication of different genomic regions, with potential implications for development and genome stability. more...