Similar studies for GEO DataSets (Select 200059471) - GEO DataSets

Select item 2000594711.

Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma

(Submitter supplied) The authors previously suggested that CD204 was a useful marker for tumor-associated macrophages (TAMs) of esophageal squamous cell carcinoma (ESCC). In this study, they discovered that within ESCC microenvironment not only cancer cells but also TAMs expressed cysteine-rich, angiogenic inducer, 61 (Cyr61), induced by conditioned media of ESCC cells. Levels of Cyr61 expression were associated with CD204+ macrophage infiltration in ESCC tissue. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
2 Samples

Download data: TXT

Series

Accession:: GSE59471

ID:: 200059471

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001186422.

ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma

(Submitter supplied) Tumor-associated macrophages (TAMs) have important roles in the progression, angiogenesis and motility of various cancers. To study the effects of TAMs on the tumor microenvironment of ESCCs, we constructed an in vitro system for the differentiation of peripheral blood monocyte (PBMo)-derived macrophages into TAM-like PBMo-derived macrophages. We established a co-culture assay using a human ESCC cell line and TAM-like PBMo-derived macrophages and we performed a cDNA microarray analysis between monocultured and co-cultured ESCC cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL

Series

Accession:: GSE118642

ID:: 200118642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000113733.

Gene expression profile analysis for the Fascin knockdown esophageal squamous carcinoma cells

(Submitter supplied) Fascin, an actin-binding protein, is upregulated in a variety of cancers, including esophageal squamous cell carcinoma (ESCC) and is proposed to function in cellular growth, mobility and invasiveness. Nonetheless, the molecular mechanisms through which fascin expression contributes to the proliferation and invasiveness of ESCC are unknown. To address this issue and to identify genes and biological pathways associated with fascin expression, a genome-wide gene expression analysis was performed on a fascin RNAi-depleted cell line and a corresponding ESCC cell line previously determined to express high levels of fascin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL, EXP

Series

Accession:: GSE11373

ID:: 200011373

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001340674.

RNA Sequencing of Wild Type and CCR2-/- mouse esophageal tumor transcriptomes

(Submitter supplied) Wild type and CCR2-/- C57 mice were gavaged with carboxyl methyl cellulose (1%) or N-nitrosomethylbenzylamine(NMBA) 0.25 mg/kg body weight (BW) twice per week for 5 weeks. At the end of Week 25, the forestomach were harvested to carry out RNA resequencing. We found that CCR2 mediated monocyte infiltration promoted tumor evasion through activating PD-1 signaling pahtway.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: XLSX

Series

Accession:: GSE134067

ID:: 200134067

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000904645.

Rat esophagus: Control vs. NMBA vs. Tocopherols

(Submitter supplied) Transcriptional profiling of rat esophageal epithelium comparing control animals, NMBA treated animals, with tocopherols intervention animals. Goal was to determine the effects of tocopherols on gene expression underlying the chemoprevention of NMBA-induced esophageal carcinogenesis.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL15084
25 Samples

Download data: TXT

Series

Accession:: GSE90464

ID:: 200090464

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002563606.

SPP1 represents a therapeutic target that promotes the progression of esophageal squamous cell carcinoma by driving M2 macrophage infiltration

(Submitter supplied) Background: Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME). However, the crosstalk between esophageal squamous cell carcinoma (ESCC) cells and TAMs remains largely unexplored. Methods: Clinical samples and the TCGA database were used to evaluate the relevance of SPP1 and TAM infiltration in ESCC. Mouse models were constructed to investigate the roles of macrophages educated by SPP1 in ESCC. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28038
6 Samples

Download data: TXT

Series

Accession:: GSE256360

ID:: 200256360

PubMed

Select item 2000536257.

LncRNA profile study reveals a three-lncRNA signature associated with the survival of esophageal squamous cell carcinoma patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL18109
358 Samples

Download data: TXT

Series

Accession:: GSE53625

ID:: 200053625

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000536248.

LncRNA profile study reveals a three-lncRNA signature associated with the survival of esophageal squamous cell carcinoma patients (original)

(Submitter supplied) Objective: Globally, esophageal cancer is among the most deadly cancer forms. Long non-coding RNAs (lncRNA) are frequently found to have important regulatory roles. We aim to assess the lncRNA expression profile of esophageal squamous cell carcinoma (ESCC) and identify prognosis related lncRNAs. Design: LncRNA expression profiles were studied by microarray in paired tumor and normal tissues from 119 ESCC patients, and validated by qRT-PCR. more...