Similar studies for GEO DataSets (Select 200061096) - GEO DataSets

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Items: 3

Select item 2000610961.

Transcriptional Program of Kpna2 (Importin-α2) Regulates Cellular Differentiation-Coupled Circadian Clock Development in Mammalian Cells

(Submitter supplied) The circadian clock in mammalian cells is cell-autonomously generated during the cellular differentiation process, but the underlying mechanisms are not understood. Here we show that perturbation of transcriptional program by constitutive expression of c-Myc and Dnmt1 ablation disrupts the differentiation-coupled emergence of the clock from mouse embryonic stem cells (ESCs). Using these model ESCs, 484 genes are identified by global gene expression analysis as factors correlated with differentiation-coupled circadian clock development. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5642
4 Samples

Download data: TXT

Series

Accession:: GSE61096

ID:: 200061096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000611842.

Transcriptional Program of Kpna2 (Importin-alpha2) Regulates Cellular Differentiation-Coupled Circadian Clock Development in Mammalian Cells

(Submitter supplied) The circadian clock in mammalian cells is cell-autonomously generated during the cellular differentiation process, but the underlying mechanisms are not understood. Here we show that perturbation of transcriptional program by constitutive expression of c-Myc and Dnmt1 ablation disrupts the differentiation-coupled emergence of the clock from mouse embryonic stem cells (ESCs). Using these model ESCs, 484 genes are identified by global gene expression analysis as correlating factors with differentiation-coupled circadian clock development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16173
15 Samples

Download data: BW

Series

Accession:: GSE61184

ID:: 200061184

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001072613.

Disruption of circadian clockwork in in vivo reprogramming-induced mouse kidney tumors

(Submitter supplied) The circadian clock, which regulates cellular physiology, such as energy metabolism, resides in each cell level throughout the body. Recently, it has been elucidated that the cellular circadian clock is closely linked with cellular differentiation. Moreover, the misregulation of cellular differentiation in mouse embryonic stem cells (ESCs) induced abnormally differentiated cells with impaired circadian clock oscillation, concomitant with the post-transcriptional suppression of CLOCK proteins. more...