Similar studies for GEO DataSets (Select 200065999) - GEO DataSets

Select item 2000659991.

The contribution of Alu exons to the human proteome

(Submitter supplied) Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

Download data: TXT

Series

Accession:: GSE65999

ID:: 200065999

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000947812.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [hnRNPC FLASH CLIP-seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
4 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE94781

ID:: 200094781

PubMed Similar studies SRA Run Selector

Select item 2000897513.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [XL8 DHX9 FLASH CLIP-seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
4 Samples

Download data: BED, BIGWIG, GFF

Series

Accession:: GSE89751

ID:: 200089751

PubMed Similar studies SRA Run Selector

Select item 2000895984.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [XL9 DHX9 FLASH CLIP-seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
4 Samples

Download data: BED, BIGWIG, GFF

Series

Accession:: GSE89598

ID:: 200089598

PubMed Similar studies SRA Run Selector

Select item 2000892765.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [XL1 DHX9 FLASH CLIP-seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: BED, BIGWIG, GFF

Series

Accession:: GSE89276

ID:: 200089276

PubMed Similar studies SRA Run Selector

Select item 2000851646.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome

(Submitter supplied) Transposable elements are viewed as ‘selfish genetic elements’, yet they contribute to gene regulation and genome evolution in diverse ways. More than half of the human genome consists of transposable elements. With over 1 million insertions, Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with over 1 million insertions they make up more than 10% of the human genome. more...

Organism:: Homo sapiens; Drosophila melanogaster; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

6 related Platforms
90 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE85164

ID:: 200085164

PubMed Similar studies

Select item 2000851617.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [RNA-Seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: BIGWIG

Series

Accession:: GSE85161

ID:: 200085161

Select item 2000851558.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [uvCLAP CLIP-seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...

Organism:: Homo sapiens; Drosophila melanogaster; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

4 related Platforms
52 Samples

Download data: BED, BIGWIG, NARROWPEAK

Series

Accession:: GSE85155

ID:: 200085155

PubMed Similar studies SRA Run Selector

Select item 2001324479.

Origin of a novel CYP20A1 lncRNA through 23 Alu exaptations in the human lineage creates a potential multi-miRNA sponge

(Submitter supplied) Alu repeats contribute to lineage specific novelties in conserved transcriptional regulatory networks. We report for the first time the origin of a multi-miRNA human specific sponge through exaptation of 23 Alu repeats that forms a novel principal isoform of CYP20A1 gene with a 9kb 3’UTR. This 3’UTR, confirmed by RACE, is an outlier in terms of its length with expression in multiple cell lines, including brain as evidenced from single nucleus RNA-seq data of 16000 human cortical neurons. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
42 Samples

Download data: DIFF, GFF3, GTF

Series

Accession:: GSE132447

ID:: 200132447

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016559510.

Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations find a uniqueness in oligodendroglioma

(Submitter supplied) Alu is a primate-specific repeat element in the human genome and has been increasingly appreciated as a regulatory element in many biological processes. But the role of Alu has not been studied comprehensively in brain tumor because an evolutionary perspective has been the subject of little research in brain tumor. We aim to investigate the relevance of Alu to the gliomagenesis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
82 Samples

Download data: CSV

Series

Accession:: GSE165595

ID:: 200165595

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20025227911.

On the genetic basis of tail-loss evolution in humans and apes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21626 GPL24247
19 Samples

Download data: BW, TAB

Series

Accession:: GSE252279

ID:: 200252279

PubMed Full text in PMC Similar studies

Select item 20025227812.

On the genetic basis of tail-loss evolution in humans and apes [Capture-seq]

(Submitter supplied) The loss of the tail is among the notable anatomical changes to have occurred along the evolutionary lineage leading to humans and to the “anthropomorphous apes”, with a hypothesized role in contributing to human bipedalism. Yet, the genetic mechanism that facilitated tail-loss evolution in hominoids remains unknown. Here, we present evidence that an individual insertion of an Alu element in the genome of the hominoid ancestor may have contributed to tail-loss evolution. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21626
11 Samples

Download data: BW

Series

Accession:: GSE252278

ID:: 200252278

PubMed Full text in PMC Similar studies

Select item 20025219613.

On the genetic basis of tail-loss evolution in humans and apes [RNA-seq]

(Submitter supplied) The loss of the tail is one of the main anatomical evolutionary changes to have occurred along the lineage leading to humans and to the “anthropomorphous apes”. This morphological evolution in the ancestral hominoids has long been considered to have accommodated a characteristic style of locomotion and contributed to the evolution of bipedalism in humans. Yet, the genetic mechanism that facilitated tail-loss evolution in hominoids remains unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TAB

Series

Accession:: GSE252196

ID:: 200252196

PubMed Full text in PMC Similar studies

Select item 20011093614.

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

(Submitter supplied) In humans, fetal erythropoiesis takes place in the liver whereas adult erythropoiesis occurs in the bone marrow. Fetal and adult erythroid cells are not only produced at different sites, but are also distinguished by their respective transcriptional program. In particular, whereas fetal erythroid cells express γ-globin chains to produce fetal hemoglobin (HbF), adult cells express β-globin chains to generate adult hemoglobin. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: TXT

Series

Accession:: GSE110936

ID:: 200110936

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009899315.

An erythroid-specific enhancer of ATP2B4 mediates red blood cell hydration and malaria susceptibility

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; SNP genotyping by SNP array; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL11154 GPL18900
74 Samples

Download data: TXT

Series

Accession:: GSE98993

ID:: 200098993

PubMed Full text in PMC Similar studies

Select item 20009899216.

An erythroid-specific enhancer of ATP2B4 mediates red blood cell hydration and malaria susceptibility [genotype]

(Submitter supplied) Few genotype-phenotype associations identified by genome-wide association studies (GWAS) have been defined mechanistically, precluding thorough assessment of their impact on human health. We conducted an expression quantitative trait loci (eQTL) mapping analysis in human erythroblasts and found erythroid-specific eQTLs for ATP2B4, the main calcium ATPase of red blood cells (RBC). The same SNPs were previously associated with mean corpuscular hemoglobin concentration (MCHC) and susceptibility to severe malaria infection. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL18900
26 Samples

Download data: TXT

Series

Accession:: GSE98992

ID:: 200098992

PubMed Full text in PMC Similar studies

Select item 20009087817.

An erythroid-specific enhancer of ATP2B4 mediates red blood cell hydration and malaria susceptibility [RNA-seq]

(Submitter supplied) Few genotype-phenotype associations identified by genome-wide association studies (GWAS) have been defined mechanistically, precluding thorough assessment of their impact on human health. We conducted an expression quantitative trait loci (eQTL) mapping analysis in human erythroblasts and found erythroid-specific eQTLs for ATP2B4, the main calcium ATPase of red blood cells (RBC). The same SNPs were previously associated with mean corpuscular hemoglobin concentration (MCHC) and susceptibility to severe malaria infection. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: TXT

Series

Accession:: GSE90878

ID:: 200090878

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20007614918.

Gene expression profiling of sensory epithelium of cochleas and vestibules of the inner ears of wild-type C57Bl/6J mice at post-natal day 0 (P0)

(Submitter supplied) The sensory epithelium of cochleas and vestibules of mice were compared. The two tissues are quite similar in structure, but have distinct roles in hearing and balance. By comparing their gene expression, we hoped to identify key regulators of differentiation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE76149

ID:: 200076149

PubMed Full text in PMC Similar studies SRA Run Selector

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