Similar studies for GEO DataSets (Select 200066863) - GEO DataSets

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Items: 20

Select item 2000668631.

Genome-wide DNA methylation signature in lung adenocarcinomas has prognostic impact [gene expression]

(Submitter supplied) Purpose: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer has in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. Experimental Design: We determined whole-genome DNA methylation profiles of 164 lung adenocarcinoma samples and 19 samples of matched normal lung tissue samples using the Illumina Infinium 450K array [GSE66836]. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
121 Samples

Download data: TXT

Series

Accession:: GSE66863

ID:: 200066863

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000668362.

Genome-wide DNA methylation signature in lung adenocarcinomas has prognostic impact

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
183 Samples

Download data: IDAT

Series

Accession:: GSE66836

ID:: 200066836

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000377453.

Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis and tissue microarray validation

(Submitter supplied) Background: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multi-gene signatures in clinical practice is unclear and the biological importance of individual genes is difficult to assess as the published signatures virtually do not overlap. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
196 Samples

Download data: CEL

Series

Accession:: GSE37745

ID:: 200037745

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Select item 2000328674.

DNA methylation and gene expression in lung adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Expression profiling by array

Platforms:: GPL6884 GPL8490
289 Samples

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Series

Accession:: GSE32867

ID:: 200032867

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Select item 2000328665.

Genome-scale DNA methylation profiling of lung adenocarcinoma: validation using Ontario Tumor Bank samples

(Submitter supplied) The independent population of lung adenocarcinoma and adjacent non-tumor lung used for verification of the EDRN/Canary Foundation study

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
55 Samples

Download data: TXT

Series

Accession:: GSE32866

ID:: 200032866

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000328636.

Gene expression analysis of lung adenocarcinoma and matched adjacent non-tumor lung tissue

(Submitter supplied) Gene expression profiling of 60 lung adenocarcinoma tumors and their matched histologically normal adjacent lung tissue samples were analyzed using Illumina HumanWG-6 v3.0 expression beadchip. We integrated these data with DNA methylation profiles of the same samples to identify potential DNA methylation regulated genes. Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
116 Samples

Download data: TXT

Series

Accession:: GSE32863

ID:: 200032863

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Select item 2000328617.

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

(Submitter supplied) Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung adenocarcinoma is a heterogeneous disease, which has important implications for treatment. Here we performed genome-scale DNA methylation profiling using the Illumina Infinium HumanMethylation27 platform on 59 matched lung adenocarcinoma/non-tumor lung samples, with genome-scale verification on an independent set of tissues. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
118 Samples

Download data: TXT

Series

Accession:: GSE32861

ID:: 200032861

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Select item 2000606458.

Genome-wide DNA methylation and expression analysis of lung carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL10558
253 Samples

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Series

Accession:: GSE60645

ID:: 200060645

Select item 2000606449.

Genome-wide DNA methylation analysis of lung carcinoma : Gene expression data

(Submitter supplied) Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. Experimental Design Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on 12 normal lung tissues and 124 tumors including 83 adenocarcinomas, 23 squamous cell carcinomas (SqCC), one adenosquamous cancer, five large cell carcinomas, nine large cell neuroendocrine carcinomas (LCNEC), and three small cell carcinomas (SCLC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
117 Samples

Download data: TXT

Series

Accession:: GSE60644

ID:: 200060644

Select item 20005604410.

Genome-wide DNA methylation analysis of lung carcinoma

(Submitter supplied) Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer is not well studied. We performed whole-genome methylation analysis using 450K Illumina BeadArrays on 124 tumors including 83 adenocarcinomas, 23 squamous cell carcinomas, one adenosquamous cancer, five large cell carcinomas, nine large cell neuroendocrine carcinomas (LCNEC), three small cell carcinomas (SCLC) and 12 normal lung tissues. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
136 Samples

Download data: TXT, XLS

Series

Accession:: GSE56044

ID:: 200056044

Select item 20007209411.

KRAS mutation-associated gene expression, p53 and STK11 mutations, proliferation and immune surveillance in lung adenocarcinoma

(Submitter supplied) While mutations in the KRAS oncogene are amongst the most prevalent in human cancer, there are few successful treatments to target these tumors. It is also likely that heterogeneity in KRAS-mutant tumor biology significantly contributes to the response to therapy. We hypothesized that presence of commonly co-occurring mutations in STK11 and TP53 tumor suppressors may represent a significant source of heterogeneity in KRAS-mutant tumors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15048
442 Samples

Download data: CEL

Series

Accession:: GSE72094

ID:: 200072094

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Select item 20003384812.

MERLION LUNG CANCER STUDY_2_DNA

(Submitter supplied) East-Asian (EA) patients with Non Small Cell Lung Cancer (NSCLC) are associated with a high proportion of non-smoking women, EGFR activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We identify copy number alterations specific to EA and Western European (WE) NSCLCs and conducted an integrative analysis using transcritomic data for identifying copy-number-driven candidate genes. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL6801
226 Samples

Download data: CEL

Series

Accession:: GSE33848

ID:: 200033848

PubMed Similar studies

Select item 20004841413.

Unique microRNA profiles in EGFR-mutated lung adenocarcinomas

(Submitter supplied) We have examined the microRNA expression in 154 lung adenocarcinoma samples and 20 paired normal lung tissue samples and investigated the microRNA expression to clinical variables, EGFR- and KRAS- mutational status and time to progression.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16770
174 Samples

Download data: TXT

Series

Accession:: GSE48414

ID:: 200048414

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006295014.

DNA Methylation and RNA Expression Profiles in Lung Adenocarcinomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL8432 GPL8490
112 Samples

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Series

Accession:: GSE62950

ID:: 200062950

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Select item 20006294915.

DNA Methylation and RNA Expression Profiles in Lung Adenocarcinomas [RNA Expression]

(Submitter supplied) Lung cancer occurs in never-smokers. Epigenetic changes in lung cancer potentially represent important diagnostic, prognostic, and therapeutic targets. We compared DNA methylation profiles of 28 adenocarcinomas of the lungs of never-smokers with paired adjacent nonmalignant lung tissue. We correlated differential methylation changes with gene expression changes from the same 28 samples. We observed a distinct separation in methylation profiles between tumor and adjacent nonmalignant lung tissue using principal component analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8432
56 Samples

Download data: TXT

Series

Accession:: GSE62949

ID:: 200062949

PubMed Full text in PMC Similar studies

Select item 20006294816.

DNA Methylation and RNA Expression Profiles in Lung Adenocarcinomas [DNA methylation]

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
56 Samples

Download data: TXT

Series

Accession:: GSE62948

ID:: 200062948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007673017.

Affymetrix SNP array data for NSCLC samples

(Submitter supplied) Non-small cell lung cancer (NSCLC) presents a notoriously genomically unstable cancer type, with numerous large scale and focal genomic aberrations resulting in gene copy number variations across the whole genome. The relations of these gene copy number changes to subsequent mRNA levels are only fragmentarily understood. The aim of this study was an integrated analysis of gene copy number changes and corresponding gene expression in a large clinically annotated NSCLC patient cohort. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL3718
190 Samples

Download data: CEL

Series

Accession:: GSE76730

ID:: 200076730

PubMed Full text in PMC Similar studies

Select item 20002858218.

Gene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non-Small Cell Lung Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL3718 GPL570
201 Samples

Download data: CEL

Series

Accession:: GSE28582

ID:: 200028582

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002857219.

Gene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non-Small Cell Lung Cancer (copy number data)

(Submitter supplied) Hypothesis: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups. Results: Genetic aberrations were strongly associated with tumor histology. more...