GEO DataSets

(Submitter supplied) Little is known about the expression of methicillin-resistant Staphylococcus aureus (MRSA) genes during infection conditions. Here, we described the transcriptome of the clinical MRSA strain USA300 derived from human cutaneous abscesses, and compared it with USA300 bacteria derived from infected kidneys in a mouse model. Remarkable similarity between the transcriptomes allowed us to identify genes encoding multiple proteases and toxins, and iron- and peptide-transporter molecules, which are upregulated in both infections and are likely important for establishment of infection. more...

Organism:

Staphylococcus aureus subsp. aureus USA300; Staphylococcus aureus subsp. aureus USA300_FPR3757

Type:

Expression profiling by array

Platform:

GPL20994

16 Samples

Download data: TXT

(Submitter supplied) The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that differential gene expression contributes substantially to this process. Thus, we here investigated the role of the pivotal virulence gene regulatory system agr in the most prevalent CA-MRSA strain USA300. more...

Organism:

Staphylococcus aureus subsp. aureus USA300; Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL8069

18 Samples

Download data: CEL, CHP

(Submitter supplied) Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed a composite DNA-microarray (StaphVar Array) which selectively targets 403 genes located on the accessory or core variable genome. more...

Organism:

Staphylococcus aureus

Type:

Genome variation profiling by array

Platform:

GPL7684

26 Samples

Download data: GPR

(Submitter supplied) In order to explore the mechanism of host immune response after infection with MRSA (USA300 clone) pneumonia, we established a mouse animal infection model and took lung tissue for RNA sequencing. Then We performed gene expression profiling using RNA-seq data obtained from lung tissues at five time points.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

15 Samples

Download data: TXT