Similar studies for GEO DataSets (Select 200075680) - GEO DataSets

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Items: 20

Select item 2000756801.

Expression data from NKYS transfected with siRNAs or plasmids

(Submitter supplied) The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3 siRNA to test whether it affected epigenetic regulation, and used EZH2 mutants to study how it affected EZH2 canonical function.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
17 Samples

Download data: CEL

Series

Accession:: GSE75680

ID:: 200075680

Select item 2000806322.

Gene expression of extranodal NK/T cell lymphoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
53 Samples

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Series

Accession:: GSE80632

ID:: 200080632

Select item 2000806313.

Gene expression of extranodal NK/T cell lymphoma II

(Submitter supplied) Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
47 Samples

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Series

Accession:: GSE80631

ID:: 200080631

Select item 2000806294.

Gene expression of extranodal NK/T cell lymphoma I

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
6 Samples

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Series

Accession:: GSE80629

ID:: 200080629

Select item 2000412395.

Gene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE41239

ID:: 200041239

Select item 2000409726.

EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL570 GPL9115
52 Samples

Download data: BED, CEL

Series

Accession:: GSE40972

ID:: 200040972

Select item 2000409717.

Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
40 Samples

Download data: CEL

Series

Accession:: GSE40971

ID:: 200040971

Select item 2000409708.

ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines

(Submitter supplied) In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). Over-expression of EZH2 is implicated in tumorigenesis and correlates with poor prognosis in multiple tumor types. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
6 Samples

Download data: BED

Series

Accession:: GSE40970

ID:: 200040970

PubMed Similar studies SRA Run Selector

Select item 2002146699.

Dissecting and Targeting Noncanonical Functions of EZH2 in Multiple Myeloma via an EZH2 Degrader

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
16 Samples

Download data: BW

Series

Accession:: GSE214669

ID:: 200214669

PubMed Full text in PMC Similar studies

Select item 20021466810.

Dissecting and Targeting Noncanonical Functions of EZH2 in Multiple Myeloma via an EZH2 Degrader [RNA-seq]

(Submitter supplied) Multiple myeloma (MM) is the second most common hematological malignancy with poor prognosis. Enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of polycomb repressive complex 2 (PRC2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) for transcriptional repression. EZH2 have been implicated in numerous hematological malignancies, including MM. However, noncanonical functions of EZH2 in MM tumorigenesis are not well understood. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE214668

ID:: 200214668

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021466711.

Dissecting and Targeting Noncanonical Functions of EZH2 in Multiple Myeloma via an EZH2 Degrader [CUT&RUN]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: BW

Series

Accession:: GSE214667

ID:: 200214667

PubMed Full text in PMC Similar studies

Select item 20004131512.

Timecourse gene expression profiling of DLBCL cell line Karpas422 after EZH2 inhibitor treatment

(Submitter supplied) Ezh2 protein is the enzymatic component of the Polycomb Repressive Complex (PRC)-2, which represses its target genes by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development. Recently, hot-spot mutations of Ezh2 have been identified in diffused large B cell lymphomas (DLBCLs) and follicular lymphomas (FLs). To investigate if tumor growth is dependent on the enzymatic activity of Ezh2, we have developed a potent and selective small molecule inhibitor, EI1, which inhibits the enzymatic activity of Ezh2 through direct binding and competing with the methyl group donor S-Adenosyl methionine (SAM). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE41315

ID:: 200041315

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010778213.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL15456 GPL20301 GPL10558
41 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE107782

ID:: 200107782

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010778114.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [RNA-seq]

(Submitter supplied) EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: TXT

Series

Accession:: GSE107781

ID:: 200107781

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20010778015.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15456
9 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE107780

ID:: 200107780

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010777916.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [microarray]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
24 Samples

Download data: TXT

Series

Accession:: GSE107779

ID:: 200107779

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Select item 20010841817.

Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity

(Submitter supplied) The effect of T372E-EZH2 and Wt-EZH2 overexpression on gene expression in TOV112D cells. We found in this study that Protein Kinase A phosphorylates T372-EZH2 and wanted to determine the gene expression changes brought upon this phosphorylation. We made a point mutation (T372E) that mimicked phospho T372-EZH2. The objective was to observe transcriptional changes in TOV112D cells in response to ectopic expression of Wt-EZH2 and T372E-EZH2 point mutation in TOV112D cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE108418

ID:: 200108418

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Select item 20021871718.

EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL24676 GPL24247
244 Samples

Download data: BW

Series

Accession:: GSE218717

ID:: 200218717

PubMed Full text in PMC Similar studies

Select item 20021871619.

EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [ChIP-Seq/Cut&Run-Seq]

(Submitter supplied) We have modelled several tumor-associated PRC2 mutations in a single isogenic system in order to reveal their comparative impacts on chromatin and transcription. We have also explored the link between EZH2 mutational status and abnormal H3K27 methylation in a unique longitudinal cohort of follicular lymphoma (FL) patient samples.