Similar studies for GEO DataSets (Select 200076262) - GEO DataSets

Select item 2000762621.

Expression data of induced sputum from Unbiased BIOmarkers in Prediction of REspiratory Disease outcomes (U-BIOPRED) Project

(Submitter supplied) Asthma is a heterogeneous disease requiring understandings at molecular level that characterizes subgroups of patients with specific biomarkers to faciliate the development of targeted thearpies. We used Affymetrix U133 Plus 2.0 PM only arrays to explore the gene expression profile from induced sputum cells of 118 moderate/severe asthmatic patients and 21 healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
139 Samples

Download data: CEL

Series

Accession:: GSE76262

ID:: 200076262

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000451112.

A sputum gene expression signature of six biomarkers identifies asthma inflammatory phenotype and steroid responsiveness

(Submitter supplied) This study identifies differentially expression genes in the sputum of people with eosinophilic, neutrophilic and paucigranulocytic asthma. A selection of markers identified using this microarray were further validated using qPCR on a wider sample set.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
47 Samples

Download data: TXT

Series

Accession:: GSE45111

ID:: 200045111

Select item 2001131853.

IL-6 trans-signaling induced gene expression in airway epithelial cells

(Submitter supplied) Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. Objective: To explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma. Methods: Primary human bronchial epithelial cell (HBEC) air-liquid interface (ALI) cultures were stimulated with IL-6 and sIL-6R to establish an IL-6TS gene signature. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: TXT

Series

Accession:: GSE113185

ID:: 200113185

Select item 2000563964.

Non-invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma

(Submitter supplied) Evaluation of the airway transcriptome may reveal patterns of gene expression that are associated with clinical phenotypes of asthma. To define transcriptomic endotypes of asthma (TEA) we analyzed gene expression in induced sputum that correlate with phenotypes of disease. Gene expression was measured in sputum of subjects with asthma using Affymetrix HuGene ST 1.0 microarrays. Unsupervised clustering analysis of genes identified TEA clusters. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
112 Samples

Download data: CEL

Series

Accession:: GSE56396

ID:: 200056396

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Select item 2000898095.

Multi-tissue transcriptomics delineates the diversity of airway T cells functions in asthma

(Submitter supplied) Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues including epithelial and T cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
145 Samples

Download data: CEL

Series

Accession:: GSE89809

ID:: 200089809

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Select item 2001844336.

Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma.

(Submitter supplied) Sputum airway cells transcriptome from 19 asthmatics from the Severe Asthma Research Program at baseline and 6-8 weeks follow-up after a 40mg dose of intramuscular corticosteroid triamcinolone acetonide.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
46 Samples

Download data: TSV

Series

Accession:: GSE184433

ID:: 200184433

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Select item 2000631427.

Asthma II

(Submitter supplied) Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asmathic (notSA) and severe asthmatic (SA) patients. For demographics data, contact Dr.Sally Wenzel ([email protected])

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
155 Samples

Download data: TXT

Series

Accession:: GSE63142

ID:: 200063142

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Select item 2000750118.

Transcriptional profiling of TH2 cells identifies pathogenic features associated with asthma

(Submitter supplied) Allergic asthma and rhinitis are two common chronic allergic diseases that affect the lungs and nose, respectively. Both diseases share clinical and pathological features characteristic of excessive allergen-induced type 2 inflammation, orchestrated by memory CD4+ T cells that produce type 2 cytokines (TH2 cells). However, a large majority of subjects with allergic rhinitis do not develop asthma, suggesting divergence in disease mechanisms. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
80 Samples

Download data: TSV

Series

Accession:: GSE75011

ID:: 200075011

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Select item 2000696839.

Expression profiling in blood from subjects with severe asthma, moderate asthma, and non-asthmatics collected in the U-BIOPRED study

(Submitter supplied) Severe asthma is a collection of disease entities with varying pathophysiological characteristics (7) that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project was set up as a public-private partnership within the framework of the Innovative Medicines Initiative (IMI), engaging academia, the pharmaceutical industry and patient groups. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
498 Samples

Download data: CEL

Series

Accession:: GSE69683

ID:: 200069683

Select item 20001990310.

Expression in induced sputum during acute exacerbations in asthmatic children with/without chronic airflow obstruction

(Submitter supplied) Asthma exacerbations are associated with subsequent deficits in lung function. Here, we tested the hypothesis that a specific pattern of inflammatory responses during acute exacerbations may be associated with susceptibility to chronic airway obstruction.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
20 Samples

Download data: CEL

Series

Accession:: GSE19903

ID:: 200019903

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Select item 20014788111.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6104 GPL10558
117 Samples

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Series

Accession:: GSE147881

ID:: 200147881

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Select item 20014788012.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [sputum]

(Submitter supplied) Severe asthma is a heterogeneous disease. Transcriptomic analysis contributes to understanding the driver mechanisms necessary for developing new therapies. The aim of this study was to identify mechanistic pathways of severe asthma across two independent cohorts.