GEO DataSets

(Submitter supplied) Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans in nanomolar concentrations. Interestingly, Carolacton also inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4. The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when S. pneumoniae TIGR4 was grown in the presence of Carolacton. more...

Organism:

Streptococcus pneumoniae TIGR4

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21349

36 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton treated S. mutans biofilm cells in comparison to untreated biofilms in a time series approach.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

24 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton treated S. mutans biofilm cells in comparison to untreated biofilms after 8h of growth.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

8 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton-treated Streptococcus mutans biofilm cells in comparison to untreated biofilms in a time series approach.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

22 Samples

Download data: TXT

(Submitter supplied) Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans and inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4 in nanomolar concentrations. Interestingly, Carolacton also inhibits Escherichia coli with a defective outer membrane protein TolC . The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when E.coli TolC was grown in the presence of Carolacton. more...

Organism:

Escherichia coli

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18133

14 Samples

Download data: FASTA, TXT

(Submitter supplied) Streptococcus pneumoniae is a Gram positive bacterium that causes severe invasive infection such as pneumonia, septicemia, meningitis and otitis media especially in children, the elderly and immune-compromised patients. Pneumococcal colonization and disease is often associated with biofilm formation. Bacteria in biofilms exhibit elevated resistance both to antibiotics and to host defense systems, which often results in persistent and difficult-to-treat infections. more...

Organism:

Streptococcus pneumoniae D39

Type:

Expression profiling by array

Platform:

GPL19709

6 Samples

Download data: GPR

(Submitter supplied) For Streptococcus pneumoniae, biofilms have been suggested to promote long-term colonization of the nasopharynx and contribute to the pathology of recurrent middle ear infections. To date numerous studies have investigated the contribution of specific genetic determinants for the development of pneumococcal biofilms, however, studies examining the global changes that occur during biofilm development and how they contribute to disease are lacking. more...

Organism:

Streptococcus pneumoniae

Type:

Expression profiling by array

Platform:

GPL10220

4 Samples

Download data: TAV