GEO DataSets

(Submitter supplied) Bordetella pertussis, the etiological agent of whooping cough, regulates the expression of its virulence factors by the well-defined BvgA/S two-component regulatory system. Phosphorylated BvgA activates the virulence activated genes (vags) and represses via the activation of the bvgR gene the expression of the virulence repressed genes (vrgs). In the presence of MgSO4, known as modulating condition, the BvgA/S system is inactive, and the vrgs are expressed. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

66 Samples

Download data: TXT

(Submitter supplied) Purpose: Within the past 20 years, outbreaks of whooping cough, caused by Bordetella pertussis, have led to respiratory disease and infant mortalities, despite good vaccination coverage. This is due at least in part to the introduction of a less effective acellular vaccine in the 1990’s. It is crucial then to understand the molecular basis of B. pertussis growth and infection. The two-component system BvgA/BvgS is the B. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23369

8 Samples

Download data: XLSX

(Submitter supplied) We examined the global transcription of B. pertussis in different strains and culture conditions

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27446

6 Samples

Download data: XLSX

(Submitter supplied) We examined the BvgA fixation on the genome of B. pertussis in different strains and culture conditions

Organism:

Bordetella pertussis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL27446

7 Samples

Download data: XLSX

(Submitter supplied) Bordetella pertussis has been shown to encode regulatory RNAs, yet the post-transcriptional regulatory circuits on which they act remain to be fully elucidated. We generated mutants lacking the endonucleases RNase III and RNase E and assessed their individual impact on the B. pertussis transcriptome. RNA-Seq analysis showed differential expression of ~25% of the B. pertussis transcriptome in each mutant with only 28% overlap between data sets. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29570

15 Samples

Download data: TXT

(Submitter supplied) Bordetella pertussis is the causative agent of human whooping cough, a highly contagious respiratory disease which despite vaccination programs remains the major cause of infant morbidity and mortality. The requirement of the RNA chaperone Hfq for virulence of B. pertussis suggested that Hfq-dependent small regulatory RNAs are involved in the modulation of gene expression. High-throughput RNA sequencing revealed hundreds of putative noncoding RNAs including the RgtA sRNA. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

6 Samples

Download data: TXT

(Submitter supplied) Bordetella pertussis, the causative agent of whooping cough, produces a microcapsule at its surface but its role in pertussis pathogenesis remained to be investigated.Absence of KpsT, a membrane-associated protein involved in the polysaccharide transport resulted in the down-modulation of a large number of virulence genes which correlated with strong attenuation in vivo.

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

6 Samples

Download data: TXT