Similar studies for GEO DataSets (Select 200085275) - GEO DataSets

Select item 2000852751.

Genome-wide expression profiling of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19932
16 Samples

Download data: GPR

Series

Accession:: GSE85275

ID:: 200085275

Select item 2000852762.

Genome-wide location of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL17892
2 Samples

Download data: GPR

Series

Accession:: GSE85276

ID:: 200085276

Select item 2001554503.

The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans

(Submitter supplied) The Regulation of Ace2 and Morphogenesis (RAM) pathway is an important regulatory network in the human fungal pathogen Candida albicans. The RAM pathway’s two most well-studied components, the NDR/Lats kinase Cbk1 and its putative substrate, the transcription factor Ace2, have a wide range of phenotypes and functions. It is not clear, however, which of these functions are specifically due to the phosphorylation of Ace2 by Cbk1. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28323
18 Samples

Download data: CSV, XLSX

Series

Accession:: GSE155450

ID:: 200155450

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000349394.

Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by Elevated Temperature or Hsp90 Compromise

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL9818 GPL10637
19 Samples

Download data: TXT

Series

Accession:: GSE34939

ID:: 200034939

Select item 2000349385.

Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by Elevated Temperature or Hsp90 Compromise [ChIP-chip]

(Submitter supplied) The capacity to sense and transduce temperature signals pervades all aspects of biology, and temperature exerts powerful control over the development and virulence of diverse pathogens. In the leading fungal pathogen of humans, Candida albicans, temperature has a profound impact on morphogenesis, a key virulence trait. Many cues that induce the transition from yeast to filamentous growth are contingent on a minimum temperature of 37ºC, while further elevatation to 39ºC serves as an independent inducing cue. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL10637
3 Samples

Download data: TXT

Series

Accession:: GSE34938

ID:: 200034938

Select item 2000342556.

Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by Elevated Temperature or Hsp90 Compromise [mRNA]

(Submitter supplied) The capacity to sense and transduce temperature signals pervades all aspects of biology, and temperature exerts powerful control over the development and virulence of diverse pathogens. In the leading fungal pathogen of humans, Candida albicans, temperature has a profound impact on morphogenesis, a key virulence trait. Many cues that induce the transition from yeast to filamentous growth are contingent on a minimum temperature of 37ºC, while further elevatation to 39ºC serves as an independent inducing cue. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
16 Samples

Download data: TXT

Series

Accession:: GSE34255

ID:: 200034255

Select item 2000428867.

ChIP-Seq analysis of Candida albicans Sfl1p and Sfl2p

(Submitter supplied) Sfl1p and Sfl2p are two homologous heat shock factor-type transcriptional regulators that antagonistically control morphogenesis in Candida albicans, while being required for full pathogenesis and virulence. To understand how Sfl1p and Sfl2p exert their function, we combined genome-wide location and expression analyses to reveal their transcriptional targets in vivo together with the associated changes of the C. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15645
8 Samples

Download data: WIG

Series

Accession:: GSE42886

ID:: 200042886

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001174778.

Functional divergence of a global regulatory complex governing fungal filamentation

(Submitter supplied) Morphogenetic transitions are prevalent in the fungal kingdom. For a leading human fungal pathogen, Candida albicans, the capacity to transition between yeast and filaments is key for virulence. For the model yeast Saccharomyces cerevisiae, filamentation enables nutrient acquisition. A recent functional genomic screen in S. cerevisiae identified Mfg1 as a regulator of morphogenesis that acts in complex with Flo8 and Mss11 to enable transcriptional responses crucial for filamentation. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array; Expression profiling by array

Platforms:: GPL10636 GPL9818
21 Samples

Download data: TXT

Series

Accession:: GSE117477

ID:: 200117477

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001458319.

The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence and plays distinct roles in regulating pathogenic traits

(Submitter supplied) Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen Candida albicans. Biochemical analysis showed that CaRSC comprises 13 subunits and contains two novel non-essential members, which we named Nri1 and Nri2 (Novel RSC Interactors) that are exclusive to the CTG clade of Saccharomycotina. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27827
12 Samples

Download data: TSV

Series

Accession:: GSE145831

ID:: 200145831

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020707310.

Functional Portrait of Irf1 (Orf19.217), a Regulator of Morphogenesis and Iron Homeostasis in Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24725 GPL19036
24 Samples

Download data: BED

Series

Accession:: GSE207073

ID:: 200207073

PubMed Full text in PMC Similar studies

Select item 20020707211.

Functional Portrait of Irf1 (Orf19.217), a Regulator of Morphogenesis and Iron Homeostasis in Candida albicans [RNA-Seq]

(Submitter supplied) The fungus Candida albicans is part of the human microbiome and mainly colonises the GI tract of healthy individuals. However, when the balance in the GI tract is disturbed, the fungus can switch from a commensal to a virulent lifestyle and can turn into a life-threatening pathogen. Life in the host is characterised by a constant struggle for nutrients, essential trace elements such as iron, copper and zinc are particularly important. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19036
18 Samples

Download data: TXT

Series

Accession:: GSE207072

ID:: 200207072

PubMed Full text in PMC Similar studies

Select item 20020703312.

Functional Portrait of Irf1 (Orf19.217), a Regulator of Morphogenesis and Iron Homeostasis in Candida albicans [ChIP-Seq]

(Submitter supplied) The fungus Candida albicans is part of the human microbiome and mainly colonises the GI tract of healthy individuals. However, when the balance in the GI tract is disturbed, the fungus can switch from a commensal to a virulent lifestyle and can turn into a life-threatening pathogen. Life in the host is characterised by a constant struggle for nutrients, essential trace elements such as iron, copper and zinc are particularly important. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24725
6 Samples

Download data: BED

Series

Accession:: GSE207033

ID:: 200207033

PubMed Full text in PMC Similar studies

Select item 20016509113.

Investigation of the transcriptional effect of artificial activation of Czf1 in Candida albicans

(Submitter supplied) Goal: Phenotypic evidence suggested that the transcription factor Czf1 influences the integrity of the cell wall. RNA-seq was performed to identify cell-wall related genes whose expression changes when Czf1 is artificially activated. Result: The set of genes whose expression is increased at least 4-fold is significantly enriched for genes whose GO (gene ontology) terms are "cell surface" and "cell wall", as well as several known and putative mannosyltransferases.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19036
9 Samples

Download data: TXT, XLSX

Series

Accession:: GSE165091

ID:: 200165091

PubMed Similar studies SRA Run Selector

Select item 20012893614.

A role for the RNA Polymerase II-CTD phosphatase, FCP1 in the oxidative stress response

(Submitter supplied) Fcp1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphorylating the C-terminal domain of RNA Polymerase II. Here, we report an unanticipated role in the repression of the oxidative stress induced genes. High-throughput genetic and gene expression profiling of FCP1 mutants uncovered a link to Skn7, a key transcription factor in the oxidative stress response pathways, as well as a link to the Mediator complex kinase subunit, Cdk8. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL11232
16 Samples

Download data: TXT

Series

Accession:: GSE128936

ID:: 200128936

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001317615.

The protein kinase Tor1 regulates adhesin expression in Candida albicans

(Submitter supplied) Eukaryotic cell growth is coordinated in response to nutrient availability, growth factors, and environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin-sensitive Tor1 protein kinase, which is conserved from yeasts to humans, participates in a signaling pathway central to cellular nutrient responses. To gain insight into Tor-mediated processes in human fungal pathogens, we have characterized Tor signaling in Candida albicans. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL7476
12 Samples

Download data: GPR

Series

Accession:: GSE13176

ID:: 200013176

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004177116.

Expression of C. albicans genes during GI tract colonization and influence of efg1, efh1 and cph1 mutations

(Submitter supplied) The goals of this study were to identify the Efg1p-regulon during GI tract colonization and to compare C. albicans gene expression during colonization of different organs of the GI tract. Our results identified significant differences in gene expression between cells colonizing the cecum and ileum. In addition, during laboratory growth, efg1- null mutant cells grew to a higher density than WT cells. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
44 Samples

Download data: TXT

Series

Accession:: GSE41771

ID:: 200041771

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014237017.

Genome-wide expression profiling of Candida albicans transcription factor Rme1p

(Submitter supplied) Rme1, a conserved transcription factor among members of the ascomycete lineage, regulates meiosis and pseudohyphal growth in baker’s yeast. The genome of the meiosis-defective fungal pathogen Candida albicans encodes a Rme1 homolog, which we previously mapped within a transcriptional circuitry that controls hyphal growth. To delineate a possible role of Rme1 in C. albicans morphogenesis, we combined genome-wide expression and location analyses of Rme1. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19932
9 Samples

Download data: GPR

Series

Accession:: GSE142370

ID:: 200142370

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014215918.

Genome-wide location of Candida albicans transcription factor Rme1p

(Submitter supplied) Rme1, a conserved transcription factor among members of the ascomycete lineage, regulates meiosis and pseudohyphal growth in baker’s yeast. The genome of the meiosis-defective fungal pathogen Candida albicans encodes a Rme1 homolog, which we previously mapped within a transcriptional circuitry that controls hyphal growth. To delineate a possible role of Rme1 in C. albicans morphogenesis, we combined genome-wide expression and location analyses of Rme1. more...