GEO DataSets

(Submitter supplied) Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans and inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4 in nanomolar concentrations. Interestingly, Carolacton also inhibits Escherichia coli with a defective outer membrane protein TolC . The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when E.coli TolC was grown in the presence of Carolacton. more...

Organism:

Escherichia coli

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18133

14 Samples

Download data: FASTA, TXT

(Submitter supplied) Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans in nanomolar concentrations. Interestingly, Carolacton also inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4. The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when S. pneumoniae TIGR4 was grown in the presence of Carolacton. more...

Organism:

Streptococcus pneumoniae TIGR4

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21349

36 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton-treated Streptococcus mutans biofilm cells in comparison to untreated biofilms in a time series approach.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

22 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton treated S. mutans biofilm cells in comparison to untreated biofilms in a time series approach.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

24 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of carolacton treated S. mutans biofilm cells in comparison to untreated biofilms after 8h of growth.

Organism:

Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL10540

8 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to identify genes that can be targeted by helper drugs to counteract resistance towards ciprofloxacin (CIP). In order to reveal the impact of ciprofloxacin on the transcriptome, differential gene-expression analysis by RNA-seq was performed on the multidrug resistant E. coli strain ST131, treated with a clinically relevant concentration of ciprofloxacin (2 µg/mL).

Organism:

Escherichia coli O25b:H4-ST131

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22638

6 Samples

Download data: TXT, XML

(Submitter supplied) Caulobacter crescentus is unique in that it has two homologous, seemingly redundant outer membrane proteins, RsaFa and RsaFb, that, together with other components, form a type I protein translocation pathway for S-layer export. RsaFa and RsaFb are required to prevent intracellular accumulation and aggregation of the S-layer protein RsaA; deletion of RsaFa and RsaFb led to a general growth defect and lowered cellular fitness. more...

Organism:

Caulobacter vibrioides

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22063

15 Samples

Download data: WIG

(Submitter supplied) Efflux of antimicrobial compounds from bacterial cells is one of the important mechanisms responsible for multi-drug resistance (MDR). Inhibiting the activity of efflux pumps using chemosensitizers like 1-(1-naphthylmethyl)-piperazine (NMP) is currently considered as a promising strategy to overcome MDR. However, additional effects of NMP other than inhibition are rarely if ever considered. Here, using phenotypic, phenotypic microarray and transcriptomic assays we show that NMP plays a role in membrane destabilization in MDR Klebsiella pneumoniae MGH 78578 strain. more...

Organism:

Klebsiella pneumoniae MGH 78578

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25825

8 Samples

Download data: TXT