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Links from GEO DataSets

Items: 20

1.

Genes differentially expressed in long-term hematopoietic stem cells with latexin deletion

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE94665
ID:
200094665
2.

Genes differentially expressed in long-term hematopoietic stem cells with latexin deletion [multipotent progenitor cells, MPPs]

(Submitter supplied) Latexin is a hematopoietic stem cells (HSCs) and progenitor cells (HPCs) regulatory gene. Its deletion leads to the expansion of HSC and HPC population. The underlying mechanims are largely unknown. We therefore perfored microarrary analysis in HPCs with (Lxn-/-) and without (wild-type, WT) latexin deletion, and determined genes that were altered by latexin deletion. This led us to identify the molecular mechanims by which latexin regulates HSC function.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE94664
ID:
200094664
3.

Genes differentially expressed in long-term hematopoietic stem cells with latexin deletion [Long-term hematopoietic stem cells, LT-HSCs]

(Submitter supplied) Latexin is a hematopoietic stem cell (HSC) regulatory gene. Its deletion leads to the expansion of HSC population. The underlying mechanims are largely unknown. We therefore perfored microarrary analysis in HSCs with (Lxn-/-) and without (wild-type, WT) latexin deletion, and determined genes that were altered by latexin deletion. This led us to identify the molecular mechanims by which latexin regulates HSC function.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE94663
ID:
200094663
4.

Latexin regulates hematopoiesis in a sex-dependent manner by differential expression of sex chromosome-specific microRNA 98-3p and thrombospondin 1

(Submitter supplied) To investigate the molecular mechanism underlying gender-specific regulation of hematopoiesis by Lxn. RNA sequencing was performed on LSK cells that were isolated from male and female WT and Lxn-/- mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
14 Samples
Download data: RESULTS
Series
Accession:
GSE213283
ID:
200213283
5.

Hhex regulates HSC self-renewal and stress hematopoiesis via repression of Cdkn2a

(Submitter supplied) The Hematopoietically-expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic progenitors and B-cells during development. We have recently shown that in adult hematopoiesis, Hhex is dispensable for maintenance of hematopoietic stem cells (HSCs) and myeloid lineages but essential for the commitment of Common Lymphoid Progenitors (CLPs) to lymphoid lineages. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE86209
ID:
200086209
6.

Functional screen for novel regulators of murine hematopoietic stem cell in vivo repopulating activity

(Submitter supplied) Although Hematopoietic Stem Cell Transplantation (HSCT) routinely treats hematologic disease, many patients experience adverse outcomes. Understanding the molecular regulation of HSC engraftment is paramount to improving HSCT regimens. Here, we executed a large-scale transplant-based functional screen for novel regulators of HSC repopulation.. Of >50 gene candidates tested, 18 were required for in vivo hematopoietic repopulation and two were detrimental to repopulation, as their loss enhanced this activity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE63830
ID:
200063830
7.

Gene expression in LSK cells of C57B/L6, DBA/2J, B.D(Chr5), & D.B(Chr5) mice

(Submitter supplied) These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6238
11 Samples
Download data: TXT
Series
Accession:
GSE21896
ID:
200021896
8.

CCCTC-binding factor is essential for the mouse hematopoietic stem cell maintenance and quiescence

(Submitter supplied) Hematopoiesis is a series of lineage differentiation programs initiated from hematopoietic stem cells (HSCs) in the bone marrow (BM). To maintain lifelong hematopoiesis, the pool of HSCs is precisely maintained by diverse molecular mechanisms. CCCTC-binding factor (CTCF) is a DNA-binding zinc-finger protein which regulates its target gene expression by organizing higher order chromatin structures. Currently, the role for CTCF in controlling HSC homeostasis is unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE88995
ID:
200088995
9.

Transcript profiling of Lin-Sca-1+c-Kit+ (LSK) cells from mice reconstituted with wild type and necdin null fetal liver cells following a sublethal dose of irradiation (6,5 Gy)

(Submitter supplied) compare the gene expression profile between irradiated Lin-Sca-1+c-Kit+ (LSK) cells from mouse bone marrow reconstituted with wild type and necdin null fetal liver cells The Affymetrix oligonucleotide array was used for this analysis
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE39153
ID:
200039153
10.

Extracellular matrix protein Matrilin-4 regulates HSC stress response

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
12 Samples
Download data: IDAT
Series
Accession:
GSE72814
ID:
200072814
11.

Gene expression analysis of transplanted wt and Matn4-/- hematopoietic stem cells (HSC)

(Submitter supplied) This study aimed at identifying the differences in expression levels between wt and Mant4-/- HSCs after transplantation, to determine the mechanism through which Mant4-/- gain a proliferative advantage.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE72813
ID:
200072813
12.

Gene expression analysis of PBS or IFNalpha treated wt hematopoietic stem cells (HSC)

(Submitter supplied) This study aimed at identifying the differences in expression levels between HSCs isolated from PBS or IFNa treated mice to determine the mechanism of activation of HSCs by IFNa.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE72812
ID:
200072812
13.

Effect of Ythdf2 in haematopoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL13112 GPL19057
38 Samples
Download data: NARROWPEAK
Series
Accession:
GSE142021
ID:
200142021
14.

Effect of Ythdf2 in haematopoiesis [meRIP-seq]

(Submitter supplied) The mRNA m6A reader YTHDF2 is overexpressed in human acute myeloid leukaemias. To understand the role of YTHDF2 in normal haematopoiesis and ageing, we performed SMART-seq on haematopoietic stem cells (HSCs) derived from young and aged (1 year old) mice. In parallel, to identify transcripts likely methylated in HSCs we performed meRIP-seq analysis of c-Kit+ cells.
Organism:
Mus musculus
Type:
Other
Platform:
GPL13112
4 Samples
Download data: NARROWPEAK
Series
Accession:
GSE142020
ID:
200142020
15.

Effect of Ythdf2 in haematopoiesis [RNA-seq]

(Submitter supplied) The mRNA m6A reader YTHDF2 is overexpressed in human acute myeloid leukaemias. To understand the role of YTHDF2 in normal haematopoiesis and ageing, we performed SMART-seq on haematopoietic stem cells (HSCs) derived from young and aged (1 year old) mice. In parallel, to identify transcripts likely methylated in HSCs we performed meRIP-seq analysis of c-Kit+ cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
34 Samples
Download data: TXT
Series
Accession:
GSE142019
ID:
200142019
16.

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL19057 GPL13112
5 Samples
Download data: BED, BW
Series
Accession:
GSE98191
ID:
200098191
17.

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [WGBS]

(Submitter supplied) Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL19057
1 Sample
Download data: BED
Series
Accession:
GSE98186
ID:
200098186
18.

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [ChIP-Seq]

(Submitter supplied) Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BW
Series
Accession:
GSE98185
ID:
200098185
19.

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [RNA-Seq]

(Submitter supplied) Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BW, XLSX
Series
Accession:
GSE98184
ID:
200098184
20.

The microRNA-212/132 cluster regulates hematopoietic stem cell maintenance and survival with age by buffering FOXO3 expression

(Submitter supplied) MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though little remains known about their role in aging hematopoietic stem cells (HSCs). The microRNA-212/132 cluster (miR-212/132) is enriched in HSCs and is up-regulated during hematopoietic aging. Both over-expression and deletion of microRNAs in this cluster leads to inappropriate hematopoiesis with age. Enforced expression of miR-132 in the bone marrow compartment of mice led to rapid HSC cycling followed by their depletion. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: BEDGRAPH
Series
Accession:
GSE66352
ID:
200066352
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