Similar studies for GEO DataSets (Select 200097617) - GEO DataSets

(Submitter supplied) Comparative analysis between oral and cutaneous wound healing in humans using paired and sequential biopsies during the repair process.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: XLSX

Series

Accession:: GSE97615

ID:: 200097615

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000230064.

Transcriptional profiling of a wound healing process in skin and oral mucosa

(Submitter supplied) When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites.

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5239 GDS5240
Platform:: GPL1261
48 Samples

Download data: CEL

Series

Accession:: GSE23006

ID:: 200023006

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52405.

Oral mucosa response to injury: time course

Analysis of oral mucosae of tongues recovering from injury for up to 10 days following wounding inflicted via punch biopsy. Results compared to those from injured skin (GDS5239) and provide insight into the molecular differences in wound healing between the skin and oral mucosa.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 stress, 8 time sets

Platform:: GPL1261
Series:: GSE23006
24 Samples

Download data: CEL

DataSet

Accession:: GDS5240

ID:: 5240

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 52396.

Skin response to injury: time course

Analysis of skin samples recovering from injury for up to 10 days following wounding inflicted via punch biopsy. Results compared to those from injured oral mucosae (GDS5240) and provide insight into the molecular differences in wound healing between the skin and oral mucosa.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 stress, 8 time sets

Platform:: GPL1261
Series:: GSE23006
24 Samples

Download data: CEL

DataSet

Accession:: GDS5239

ID:: 5239

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001188597.

SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands

(Submitter supplied) We perfomed RNA-seq and wound healing analysis to identify the mechanism how SOX2 promote wound healing. We showed that induction of SOX2 in skin keratinocytes accelerates cutaneous wound healing by promoting keratinocyte migration and proliferation, and enhancement of angiogenesis via the upregulation of EGFR ligands.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
15 Samples

Download data: XLSX

Series

Accession:: GSE118859

ID:: 200118859

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000561358.

Intrinsic differences between oral and skin keratinocytes

(Submitter supplied) The morphology and the behavior of skin and oral tissue keratinocytes are different. One significant dissimilarity between the two sites is the response to injury. Oral and skin keratinocytes have intrinsic differences in the response to injury and such differences are reflected in gene expression profiles. We used microarrays to investigate differences in global gene expression patterns between baseline skin and oral epithelium sheets without their underlying connective tissue.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE56135

ID:: 200056135

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001254239.

MicroRNA differential expression in skin and oral mucosal epithelium

(Submitter supplied) While skin and oral mucosa share many morphological similarities, oral mucosal wounds heal more rapidly than skin wounds. Epithelial cells from oral mucosa exhibit increased migratory and proliferative capacities when compared to cells from skin, suggesting that the improved repair of mucosa may involve intrinsic differences in epithelial cells. This is an exploratory experiment to define the differential microRNA expression of baseline unwounded skin and oral mucosa epithelium.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL26081
2 Samples

Download data: TXT

Series

Accession:: GSE125423

ID:: 200125423

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012199610.

miR-Seq on paired skin and oral mucosal wound healing

(Submitter supplied) To delineate the role of microRNAs in the site-specific injury response, we compared the microRNAome of skin and oral mucosa both at baseline and throughout the time course of wound healing.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
24 Samples

Download data: XLSX

Series

Accession:: GSE121996

ID:: 200121996

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002164811.

Gene expression in human oral mucosal fibroblasts and patient-matched skin fibroblasts

(Submitter supplied) Wound healing within the oral mucosa results in minimal scar formation compared to wounds within the skin. We have recently demonstrated distinct differences in the ageing profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesize that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound healing capacities. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3856
Platform:: GPL96
15 Samples

Download data: CEL, CHP

Series

Accession:: GSE21648

ID:: 200021648

Select item 385612.

Oral mucosal fibroblast response to artificial wounding stimulus

Temporal analysis of oral mucosal (OM) fibroblasts and patient-matched skin fibroblasts following serum starvation/induction. OM fibroblasts exhibit a preferential wound-healing response compared to that of dermis. Results provide insight into molecular basis of OM fibroblast wound healing response.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type, 4 individual, 2 protocol, 2 time sets

Platform:: GPL96
Series:: GSE21648
15 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3856

ID:: 3856

Select item 20022925713.

Gene expression profile at single cell level from untreated and Enterococcus faecalis-infected skin wounds

(Submitter supplied) Enterococcus faecalis (E. faecalis) is a Gram-(+) opportunistic pathogen associated with predominantly nosocomial wound infections. E. faecalis has been shown to suppress or evade immune-mediated clearance by the immune system and promote persistent infection. Here, we sought to interrogate whether E. faecalis infection induces transcriptomic changes in the host at the single-cell resolution using a mouse excisional wound model. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE229257

ID:: 200229257

PubMed Full text in PMC Similar studies

Select item 20011490814.

A global transcriptome analysis of human epidermal keratinocytes upon inhibition of lncRNA WAKMAR1

(Submitter supplied) Recent study has revealed that long non-coding RNAs (lncRNAs) perform as important regulators of cellular physiology and pathology, which makes them promising therapeutic and diagnostic entities. We found lncRNA WAKMAR1 is significantly down-regulated in wound-edge keratinocytes from venous ulcer and diabetic foot ulcer compared to the normal wounds. To study the genes regulated by WAKMAR1, we transfected lncRNA GapmeRs into human primary epidermal keratinocytes to inhibit its expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
6 Samples

Download data: CEL

Series

Accession:: GSE114908

ID:: 200114908

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011420315.

A microarray analysis of human epidermal keratinocytes upon depletion of the long non-coding RNA LOC100130476

(Submitter supplied) The lncRNA LOC100130476 (named as WAKMAR2) was found to be down-regulated in epidermal keratinocytes in human chronic non-healing wounds compared to normal acute wounds and the intact skin. However, its biological role in keratinocytes during wound repair has not been studied. To study the genes regulated by WAKMAR2, we transfected Antisense LNA GapmeR against WAKMAR2 into human primary epidermal keratinocytes to deplete it. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24324
6 Samples

Download data: CEL

Series

Accession:: GSE114203

ID:: 200114203

Select item 20004265316.

Expression of proinflammatory genes in epidermal keratinocytes is regulated by the hydration status.

(Submitter supplied) We hypothesized that treatment of the injured skin with occlusion limits TEWL and results in a phenotype of epithelial response that more closely resembles mucosa. Here we addressed whether different hydration conditions change gene expression patterns in epidermis using microarray study in rabbit partial-thickness incisional wound. Microarray on epidermis showed that global expression patterns of the genes in full occluded vs. more...