GEO DataSets

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida parapsilosis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Homo sapiens gene expression.

Organism:

Candida parapsilosis; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24976

18 Samples

Download data: CSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Candida parapsilosis; Candida tropicalis; Nakaseomyces glabratus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

75 Samples

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(Submitter supplied) RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

3 Samples

Download data: CSV

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida tropicalis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida tropicalis gene expression.

Organism:

Homo sapiens; Candida tropicalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24977

18 Samples

Download data: CSV

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida glabrata. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida glabrata gene expression.

Organism:

Nakaseomyces glabratus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24975

18 Samples

Download data: CSV

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida albicans SC5314. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

Organism:

Homo sapiens; Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24974

18 Samples

Download data: CSV

(Submitter supplied) Candidiasis is an infection caused by yeasts of the genus Candida that ranges in severity from debilitating mucosal infections to disseminated disease with high mortality rates. C. albicans is the most common cause of infection, but non-albicans species collectively represent a significant disease burden. Disseminated disease rarely affects immunocompetent individuals, largely due to the action of innate immune cells, including macrophages, in controlling infection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

21 Samples

Download data: TXT

(Submitter supplied) Pathogenic Candida fungi are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including C. albicans, the most prevalent cause of infection, belong to the monophyletic CUG clade of yeasts. Much is known about the interaction of C. albicans with innate immune cells, which are crucial for controlling infection. more...

Organism:

Candida tropicalis; Mus musculus; Candida dubliniensis; Candida albicans; Lodderomyces elongisporus; Candida parapsilosis; Clavispora lusitaniae

Type:

Expression profiling by high throughput sequencing

12 related Platforms

24 Samples

Download data: TXT

(Submitter supplied) Candidiasis affects a wide variety of immunocompromised individuals, including HIV/AIDS patients and cancer patients on chemotherapy. Candida albicans, a major human fungal pathogen, accounts for about 50% of all cases, while the remainder are caused by the less pathogenic non-albicans Candida species (NACS). These species are believed to be less pathogenic, in part, because they do not filament as readily or robustly as C. more...

Organism:

Candida tropicalis; Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21876 GPL18663

16 Samples

Download data: TXT

(Submitter supplied) To mimic the initial phases of systemic Candida infections with dissemination via the bloodstream, we used an ex vivo whole blood infection model. Dual TP of C. auris in blood gave insights into fungal adaptations and survival mechanisms as well as the host response to the infection.

Organism:

Homo sapiens; Candidozyma auris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30319

18 Samples

Download data: CSV

(Submitter supplied) Abstract: Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CUG clade in the Saccharomycotina. In contrast to C. albicans, relatively little is known about the virulence properties of C. parapsilosis, a pathogen particularly associated with infections of premature neonates. We describe here the construction of >200 C. parapsilosis strains carrying double allele deletions of transcription factors, protein kinases and species-specific genes. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18663

24 Samples

Download data: TXT

(Submitter supplied) The goals of this study are to compare C. glabrata transcriptome profiling (RNA-seq) upon exposure to hydrogen peroxide in order to assess the correspondent response. The role of the transcription factor Tog1 is clarified through comparison of the transcrptome profiles of WT and Tog1 mutant cells. mRNA profiles of WT and ∆tog1 were generated by deep sequencing, in duplicate, using Illumina HiSeq. The sequence reads that passed quality filters were analyzed with TopHat followed by HTSeq. more...

Organism:

Nakaseomyces glabratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26394

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida parapsilosis; Candida albicans

Type:

Expression profiling by array

Platforms:

GPL13192 GPL10903

18 Samples

Download data: GPR

(Submitter supplied) Whole genome microarrays were used to generate the transcriptional profile of Candida parapsilosis in low iron conditions

Organism:

Candida parapsilosis

Type:

Expression profiling by array

Platform:

GPL13192

7 Samples

Download data: GPR

(Submitter supplied) Whole genome microarrays were used to compare the transcriptional profile of Candida parapsilosis bcr1 knockout to wild type cells.

Organism:

Candida parapsilosis

Type:

Expression profiling by array

Platform:

GPL13192

7 Samples

Download data: GPR

(Submitter supplied) Whole genome microarrays were used to compare the transcriptional profile of Candida albicans bcr1 knockout to wild type cells.

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL10903

4 Samples

Download data: GPR

(Submitter supplied) Tyrosol plays a key role in fungal morphogenesis and biofilm development. Also, it has a remarkable antifungal effect at supraphysiological concentrations. However, the background of the antifungal effect remains unknown, especially in the case of non-albicans Candida species such as Candida parapsilosis We examined the effect of tyrosol on the growth, adhesion, redox homeostasis, virulence, as well as on fluconazole susceptibility. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24494

6 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6885 GPL22078 GPL6887

80 Samples

Download data: GPR

(Submitter supplied) The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding of the organ-specific differences in host-pathogen interaction during systemic murine candidiasis, we performed a time-course gene expression profiling to investigate the differential responses of murine kidney, liver and spleen and determined the fungal transcriptome in liver and kidney. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

9 Samples

Download data: TXT

(Submitter supplied) The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding of the organ-specific differences in host-pathogen interaction during systemic murine candidiasis, we performed a time-course gene expression profiling to investigate the differential responses of murine kidney, liver and spleen and determined the fungal transcriptome in liver and kidney. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

54 Samples

Download data: TXT