Similar studies for GEO DataSets (Select 200117425) - GEO DataSets

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Items: 3

Select item 2001174251.

Transcriptional profile of Mouse liver after MitoCDNB application

(Submitter supplied) To assess the effect of MitoCDNB on transcriptional profile of mouse liver tissue we injected mice with either vehicle (0.1 % ethanol) or 5 mg/kg of MitoCDNB. Liver was taken from both vehicle or MitoCDNB injected mice after 1 or 4 hours and the transcriptome assessed using Illumina RNASeq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
24 Samples

Download data: CSV

Series

Accession:: GSE117425

ID:: 200117425

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000378742.

Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

(Submitter supplied) Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4928
Platform:: GPL8321
12 Samples

Download data: CEL

Series

Accession:: GSE37874

ID:: 200037874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49283.

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.