GEO DataSets

(Submitter supplied) Exosomal miRNAs including 86 exosomal miRNAs were significantly increased and 354 exosomal miRNAs were significantly decreased in the co-injection group compared to LLC injection alone through expression profiling of a total of 1903 genes.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL21265

2 Samples

Download data: TXT

(Submitter supplied) we analyzed transcriptomic profiles in LLC cells isolated from primary cancer sites. C57BL/6 mice were subcutaneously injected with LLC-RFP with or without BMSCs.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23479

6 Samples

Download data: TXT

(Submitter supplied) MiRNA microarray analysis was performed on exosomes secreted by mouse MSC cells under two different conditions of normal oxygen and hypoxia, in order to find out the different miRNAs in exosomes secreted by MSC under two different conditions.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL22383

2 Samples

Download data: TXT

(Submitter supplied) Background: Androgen deprivation therapy (ADT) is the backbone of therapy for advanced prostate cancer (PCa). Despite the good initial response, castration resistance and metastatic progression will inevitably occur. Cancer-associated fibroblasts (CAFs) may be implicated in promoting metastasis of PCa after ADT. Our aim is to investigate the role and mechanism of CAF-derived exosomes involving in metastasis of PCa after ADT. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL20301

6 Samples

Download data: XLSX

(Submitter supplied) Studies have shown that IH may promote the development of non-small-cell lung cancer (NSCLC), Exosomes carry specific proteins, lipids, small molecule RNAs (miRNAs) as well as other bioactive substances, which play an important role in tumor growth. The role of exosomal miRNAs in the promotion of tumor development by IH has not been studied.

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

12 Samples

Download data: CEL

(Submitter supplied) Intercellular communication is crucial for breast cancer progression and metastasis. Yet, the role of cancer-derived exosomes and their specific miRNAs cargo in mediating intercellular communications needed to be further elucidated. MiRNAs control gene expression post-transcriptionally and are selectively packaged into cancer-derived exosomes. Therefore, we hypothesized that miRNAs in cancer-derived exosomes were most likely the essential components of intercellular communication. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

4 Samples

Download data: CEL

(Submitter supplied) The prognosis of hepatocellular carcinoma (HCC) is poor due to the high incidence of intrahepatic metastasis. The aim of this study is to investigate the mechanism of intrahepatic metastasis in HCC via extracellular vesicles (EVs).

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21263

2 Samples

Download data: TXT

(Submitter supplied) We have employed microRNA microarray expression profiling as a discovery platform to identify the specific microRNAs that were regulated by circLONP2.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL20712

2 Samples

Download data: TXT

(Submitter supplied) We have employed microRNA microarray expression profiling as a discovery platform to identify the specific microRNAs that were regulated by circLONP2.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL20712

2 Samples

Download data: TXT

(Submitter supplied) Exosomes are cell-derived vesicles that were found in many biological fluids such as blood, urine, and cultured medium. Exosomes are small vesicles (approximately 100nm in diameter) that contain many functional molecules like cytokines, receptors and regulating RNAs. In this study, we found that uMSC-derived exosomes accelerates wound healing and reduce myoblast formation in vivo. In vitro study showed uMSC-exosomes specific microRNAs take major roles in inhibiting myoblast differentiation of fibroblast. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL17303

2 Samples

Download data: TXT

(Submitter supplied) To identify lung metastasis associated microRNAs in triple negative breast cancer (TNBC), we have employed the commercially available Agilent Human miRNA V19.0 Microarray (Platform GPL19730) as a discovery platform. In comparison with LM-Normal, 11 microRNAs significantly altered in both LM-Met and LM-Tumor, and then three of them (hsa-miR-21-3p, hsa-miR-21-5p and hsa-miR-211-3p) were excluded, which were also up-regulated in RF-Tumor. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL18044

20 Samples

Download data: TXT

(Submitter supplied) To identify novel miRNAs involved in acquired EGFR TKI resistance in NSCLC, genome-wide miRNA expression analysis was performed in gefitinib-resistant sub-cell lines and gefitinib-sensitive parental cell lines.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL18402

4 Samples

Download data: TXT, XLSX

(Submitter supplied) The present research aimed to demonstrate that pancreatic cancer related miRNAs can be transferred from exosome to dendritic cells and influence mRNA expression, inducing immune tolerance of dendritic cells .Immature dendritic cells were induced from peripheral blood monocytes and stimulated by exosomes collected from PANC-1 cell culture.Genome-wide mRNA chip were performed in iDC and exosome stimulated iDC to detect the change of mRNA expression level.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL19907

2 Samples

Download data: GPR, TXT

(Submitter supplied) To identify potential metastasis associated miRNAs in colorectal cancer (CRC), we performed miRNA array on normal mucosa, CRC tissues without metastasis and CRC tissues with distant metastasis.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL13835

3 Samples

Download data: TXT

(Submitter supplied) To isolate exosomes from colon tissue, colon tissue were removed and gently disaggregated with tweezers in dissociation buffer, followed by incubation at 37°C for 1 h. The disaggregated samples were centrifuged at 1,000 g for 10 min, 2,000 g for 20 min, 4,000 g for 30 min and 10,000 g for 1 h with the supernatant being retained each time. The tissue exosomes were collected by centrifuging the samples at 100,000 g for 1.5 h at 4°C, and the pellet was suspended in ice-cold PBS. more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL22877

21 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Bos taurus; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14767

157 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) are intrinsic regulators in the various cellular processes, and their abnormalities are considered to be involved in the onset of human disorders, including cancer. Circulating miRNA is focused as new cancer biomarker however it is regarded that circulating RNA are released not only from tumor but also by various pathways. Recently, exosomes, small membrane vesicles, have been a major interest in cancer research field, because of their unique biological properties. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14767

24 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) are intrinsic regulators in the various cellular processes, and their abnormalities are considered to be involved in the onset of human disorders, including cancer. Circulating miRNA is focused as new cancer biomarker however it is regarded that circulating RNA are released not only from tumor but also by various pathways. Recently, exosomes, small membrane vesicles, have been a major interest in cancer research field, because of their unique biological properties. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14767

99 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) are intrinsic regulators in the various cellular processes, and their abnormalities are considered to be involved in the onset of human disorders, including cancer. Circulating miRNA is focused as new cancer biomarker however it is regarded that circulating RNA are released not only from tumor but also by various pathways. Recently, exosomes, small membrane vesicles, have been a major interest in cancer research field, because of their unique biological properties. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14767

15 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) are intrinsic regulators in the various cellular processes, and their abnormalities are considered to be involved in the onset of human disorders, including cancer. Circulating miRNA is focused as new cancer biomarker however it is regarded that circulating RNA are released not only from tumor but also by various pathways. Recently, exosomes, small membrane vesicles, have been a major interest in cancer research field, because of their unique biological properties. more...

Organism:

Homo sapiens; Bos taurus

Type:

Non-coding RNA profiling by array

Platform:

GPL14767

19 Samples

Download data: TXT