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Links from GEO DataSets

Items: 16

1.

Candida albicans Sfp1 participates in the regulation of multiple antioxidative systems

(Submitter supplied) To investigate the roles of Sfp1, we used a whole-genome DNA microarray to compare gene expression patterns between the sfp1-deleted and wild-type strains. Among the upregulated genes, a subset of genes is involved in oxidative stress response, including CAP1, SSK1, and SHO1. The CAP1 gene product is a bZip transcription factor involving in regulation of antioxidant gene expression. The SSK1 and SHO1 gene encodes a response regulator of two-component system and an adaptor protein in the Hog1 MAPK signaling pathway, respectively. more...
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL26225
4 Samples
Download data: TXT
Series
Accession:
GSE127184
ID:
200127184
2.

Investigation of the transcriptional effect of artificial activation of Czf1 in Candida albicans

(Submitter supplied) Goal: Phenotypic evidence suggested that the transcription factor Czf1 influences the integrity of the cell wall. RNA-seq was performed to identify cell-wall related genes whose expression changes when Czf1 is artificially activated. Result: The set of genes whose expression is increased at least 4-fold is significantly enriched for genes whose GO (gene ontology) terms are "cell surface" and "cell wall", as well as several known and putative mannosyltransferases.
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19036
9 Samples
Download data: TXT, XLSX
Series
Accession:
GSE165091
ID:
200165091
3.

Transcriptional profiling of Candida albicans wild-type CAI-4 strans treated by Hst5

(Submitter supplied) The experiment was designed to study the transcriptional profiling of Candida albicans wild-type CAI-4 strains and corresponding Histatin 5 treated strains. Since Histatin 5 will kill Candida albicans, the focus will be on how many and which genes are significantly affected with the treatment of Histatin 5. Currently, we only conducted the microarray experiments at one concentration of Histatin 5 and one time point of treatment. more...
Organism:
Candida albicans; Candida albicans SC5314
Type:
Expression profiling by array
Platform:
GPL4920
4 Samples
Download data: GPR
Series
Accession:
GSE8473
ID:
200008473
4.

Re-masking of fungal cell wall PAMPs in response to environmental pH is regulated by multiple processes

(Submitter supplied) Candida albicans is a commensal yeast of the human gut, which is tolerated by the immune system, but has the potential to become an opportunistic pathogen. One way in which C. albicans achieves this duality is through the concealing, or exposure of cell wall associated pathogen-associated molecular patterns (PAMPs) in response to host derived environment cues (pH, hypoxia, lactate). This cell wall remodelling allows C. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24129
33 Samples
Download data: XLSX
Series
Accession:
GSE130948
ID:
200130948
5.

Disruption of the Transcriptional Regulator Cas5 Results in Enhanced Killing of Candida albicans by Fluconazole

(Submitter supplied) Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence fluconazole susceptibility, we sought to identify transcription factors (TFs) involved in this process. From a collection of C. albicans strains disrupted for genes encoding TFs (Homann et al., PLoS Genet. more...
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL6808
8 Samples
Download data: CEL
Series
Accession:
GSE57930
ID:
200057930
6.

Next-generation sequencing analysis of wild-type and PGRN-/- mouse macrophages and neutrophils challenged with Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data
Series
Accession:
GSE201167
ID:
200201167
7.

Next-generation sequencing analysis of wild-type and PGRN-/- mouse neutrophils challenged with Candida albicans [RNA-seq]

(Submitter supplied) To investigate the effect of Progranulin on neutrophils phagocytosis and killing of Candida albicans, we designed RNA-Seq analysis of wild-type and PGRN-/- neutrophils challenged with Candida albicans in vitro at one time point.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE201166
ID:
200201166
8.

Next-generation sequencing analysis of wild-type and PGRN-/- mouse macrophages challenged with Candida albicans [RNA-seq]

(Submitter supplied) To investigate the effect of progranulin on macrophages phagocytosis and killing of Candida albicans, we designed RNA-Seq analysis of wild-type and PGRN-/- macrophages challenged with Candida albicans in vitro at one time point.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE201165
ID:
200201165
9.

Cross talk between the cell wall integrity and cAMP/protein kinase A pathways in Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C. neoformans, and biosynthesis and repair of the wall is primarily controlled by the cell wall integrity (CWI) signaling pathway. Previous work by us and others have shown that deletion of genes encoding the four major kinases in the CWI signaling pathway, namely PKC1, BCK1, MKK2 and MPK1 results in severe cell wall phenotypes, sensitivity to a variety of cell wall stressors and, for Mpk1, reduced virulence in a mouse model. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14571
12 Samples
Download data: GTF, TXT
Series
Accession:
GSE57217
ID:
200057217
10.

Transcriptomes of wild-type C. albicans treated with respiration inhibitors SNP, SHAM or SNP+SHAM

(Submitter supplied) We examined the early gene expression profiles (30 min) of log-phase wild-type C. albicans growing in YPD at 30 °C in response to respiration inhbitors 1mM SNP, 0.5 mM SHAM, or 1 mM SNP+ 0.5 mM SHAM combination
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22403
12 Samples
Download data: TXT
Series
Accession:
GSE114531
ID:
200114531
11.

The Candida albicans regulator ZCF21 controls the expression of cell wall components

(Submitter supplied) We report that a transcriptional regulator that originated in the lineage that gave rise to multiple host-associated Candida species is a key component of the circuitry that governs the C. albicans cell surface composition. Specifically, we show that the transcription regulator ZCF21 controls the expression of genes encoding multiple cell surface proteins and cell wall modifying enzymes.
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19036
8 Samples
Download data: FASTA, WIG
Series
Accession:
GSE73373
ID:
200073373
12.

Transcriptional profiling of Candida albicans cells defective in glucan assembly and undergoing the Yeast to Hyphal transition

(Submitter supplied) Wild type (CAI10) and phr1 null mutant (CAS10) were analyzed at 0, 1, 3 and 5 hours after the shift of blastospores to Hyphae inducing conditions
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL9545
24 Samples
Download data: TXT
Series
Accession:
GSE51064
ID:
200051064
13.

Genome-wide location of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...
Organism:
Candida albicans
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL17892
2 Samples
Download data: GPR
Series
Accession:
GSE85276
ID:
200085276
14.

Genome-wide expression profiling of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL19932
16 Samples
Download data: GPR
Series
Accession:
GSE85275
ID:
200085275
15.

Transcript levels of genes in both the wild type SN148 and the crz1/crz1 mutant with or without 0.2M CaCl2 treatment

(Submitter supplied) We report the expression levels of transcripts for two alleles of 6,211 genes in log-phase growing cells of the wild type SN148 and the crz1/crz1 with or without 0.2M CaCl2 treatment.We find that as compared to the wild type cells without 0.2M CaCl2 treatment, there are 828 genes upregulated in the wild type cells with 0.2M CaCl2 treatment.
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23041
4 Samples
Download data: XLSX
Series
Accession:
GSE123122
ID:
200123122
16.

The GUL-1 protein binds multiple RNAs and regulates cell wall remodeling in concert with the MAK-1 pathway in Neurospora crassa

(Submitter supplied) The Neurospora crassa GUL-1 is part of the COT-1 pathway, which plays key roles in regulating polar hyphal growth and cell wall remodeling. We show that GUL-1 is a bona fide mRNA binding protein (RBP) that can associate with 828 “core” mRNA species. When cell wall integrity (CWI) is challenged, the repertoire of associated RNA species increases up to 2628 mRNAs (including its own transcript). GUL-1 can bind mRNAs of genes related to translation, cell wall remodeling, circadian clock, endoplasmatic reticulum (ER), as well as CWI and osmoregulatory response MAPK pathway components. more...
Organism:
Neurospora crassa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26551
22 Samples
Download data: CSV
Series
Accession:
GSE152935
ID:
200152935
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