Similar studies for GEO DataSets (Select 200128936) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2001289361.

A role for the RNA Polymerase II-CTD phosphatase, FCP1 in the oxidative stress response

(Submitter supplied) Fcp1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphorylating the C-terminal domain of RNA Polymerase II. Here, we report an unanticipated role in the repression of the oxidative stress induced genes. High-throughput genetic and gene expression profiling of FCP1 mutants uncovered a link to Skn7, a key transcription factor in the oxidative stress response pathways, as well as a link to the Mediator complex kinase subunit, Cdk8. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL11232
16 Samples

Download data: TXT

Series

Accession:: GSE128936

ID:: 200128936

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000431202.

RNAPII CTD dataset

(Submitter supplied) The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction and mRNA expression analysis we found that truncating the CTD resulted in distinct changes to cellular function. Truncating the CTD altered RNAPII occupancy to not only cause decreases, but also increases in mRNA levels. The latter were largely mediated by promoter elements, and in part were linked to the transcription factor Rpn4. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL11232
24 Samples

Download data: TXT

Series

Accession:: GSE43120

ID:: 200043120

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001252813.

Cdk8 and Ssn801 regulate oxidative stress resistance and virulence in Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is an important pathogen that annually kills 200,000 people worldwide. It survives in the environment as a yeast or spore and can also proliferate within host macrophages after being inhaled into the lungs. In conditions of immunocompromise, cryptococcal cells can escape from the lungs to the brain, where they cause a deadly meningoencephalitis that is both difficult and expensive to treat. more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19081
21 Samples

Download data: TSV

Series

Accession:: GSE125281

ID:: 200125281

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001611404.

The Cdk8 kinase module regulates Mediator-RNA polymerase II interaction

(Submitter supplied) The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex Mediator that regulates RNA polymerase II (Pol II transcription. The CKM has negative and positive functions in gene transcription that remain poorly understood at the mechanistic level. Here, we prepare recombinant CKM from the yeast Saccharomyces cerevisiae and show that it binds core Mediator (cMed) to sterically inhibit cMed binding to the Pol II preinitiation complex (PIC) in vitro. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19756
8 Samples

Download data: TXT

Series

Accession:: GSE161140

ID:: 200161140

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000936415.

Histone H3Lys4 trimethylation in budding yeast S. cerevisiae for wild type and cnc1Djhd2D yeast mutants

(Submitter supplied) In this study, we measured histone H3Lys4 trimethylation in budding yeast S. cerevisiae for wild type and cnc1Djhd2D yeast mutants. These experiments were performed for yeast cultured to mid-logarithmic phase in non-fermentable carbon.

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13821
16 Samples

Download data: BEDGRAPH

Series

Accession:: GSE93641

ID:: 200093641

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000387486.

Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain required for efficient transcription of heat shock genes

(Submitter supplied) RNA polymerase II is decreased on heat shock-induced genes when the CTD phosphatase Fcp1 is knocked down in Drosophila S2 cells. We examined transcriptionally-engaged Pol II genome-wide with GRO-seq to determine if other genes are similarly affected.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9058
4 Samples

Download data: BED

Series

Accession:: GSE38748

ID:: 200038748

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001016307.

Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HCT116 and HEK293 cells treated with or without TNF-alpha

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL14550
56 Samples

Download data: TXT

Series

Accession:: GSE101630

ID:: 200101630

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001016298.

Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HEK293 cells treated with or without TNF-alpha

(Submitter supplied) We have investigated the effects of CDK8/19 inhibitor Senexin B on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE101629

ID:: 200101629

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001016289.

Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HCT116 cells treated with or without TNF-alpha

(Submitter supplied) We have investigated the effects of CDK8/19 inhibitor Senexin B on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE101628

ID:: 200101628

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20010162710.

Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin A in HEK293 cells treated with TNF-alpha II

(Submitter supplied) We have investigated the effects of CDK8/19 inhibitor Senexin A on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
16 Samples

Download data: TXT

Series

Accession:: GSE101627

ID:: 200101627

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010162611.

Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin A in HEK293 cells treated with TNF-alpha I

(Submitter supplied) We have investigated the effects of CDK8/19 inhibitor Senexin A on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
16 Samples

Download data: TXT

Series

Accession:: GSE101626

ID:: 200101626

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023209412.

The Mediator kinase module regulates transcriptional memory after heat stress by resolving blocked RNA polymerase complexes

(Submitter supplied) In nature, plants are often exposed to recurring adverse environmental conditions. Acclimation to high temperature stress entails transcriptional responses that are mediated by heat-shock transcription factors (HSFs), and they are primed to better withstand subsequent stress events. This heat stress (HS)-induced transcriptional memory results in more efficient re-induction of transcription upon recurring HS. more...

Organism:: Arabidopsis thaliana

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28290
36 Samples

Download data: TXT

Series

Accession:: GSE232094

ID:: 200232094

PubMed Full text in PMC Similar studies

Select item 20008527613.

Genome-wide location of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL17892
2 Samples

Download data: GPR

Series

Accession:: GSE85276

ID:: 200085276

Select item 20008527514.

Genome-wide expression profiling of Candida albicans transcription factor Skn7p

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19932
16 Samples

Download data: GPR

Series

Accession:: GSE85275

ID:: 200085275

Select item 20000297715.

Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress

(Submitter supplied) The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression of a TRX2-HIS3 fusion in the absence of H2O2. Two independent mutants isolated in this screen carried mutations in the TRR1 gene encoding thioredoxin reductase. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platforms:: GPL2659 GPL2658 GPL2657
15 Samples

Download data

Series

Accession:: GSE2977

ID:: 200002977

Select item 20016382016.

Combinatorial Gene Essentiality and Pharmacological Profiling uncovers enhancer-mediated synthetic lethal interactions with Mediator Kinase

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23227 GPL18573
38 Samples

Download data: BW

Series

Accession:: GSE163820

ID:: 200163820

PubMed Similar studies

Select item 20016381917.

Combinatorial Gene Essentiality and Pharmacological Profiling uncovers enhancer-mediated synthetic lethal interactions with Mediator Kinase [RNA-Seq]

(Submitter supplied) Depletion of CDK8 and its paralogue CDK19, resulted in a global down regulation of mRNA expression, and hence we went to investigate the binding of RNA pol II by ChIP seq at the promoter and at the gene body in the DKO cells. To determine the consequence of loss of CDK8/19 in re-defining enhancers and to underpin the molecular mechanism that providing the preferential BET sensitivity for DKO, we performed ChIP sequencing for MED12, a reminiscent mediator kinase component, BRD4 and H3K27Ac. more...