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Links from GEO DataSets

Items: 7

1.

Transcriptional analysis of glnA deletion mutant in Haloferax mediterranei

(Submitter supplied) Transcriptional profiling of Haloferax mediterranei DglnA and HM26 strains in two different culture media: a) cells were grown exponentially on complex media + 40 mM Gln, b) cells were shifted to nitrogen starvation conditions (72h). In the Nsta(∆glnA)-Cx and Nsta-Cx contrasts, glnA2 was up-regulated, and glnA3 did not show any difference. Therefore, glnA2 and glnA3 were unable to compensate lack of glnA because either they do not properly encode GS or are not expressed under the same conditions.
Organism:
Haloferax mediterranei
Type:
Expression profiling by array
Platform:
GPL18892
8 Samples
Download data: TXT
Series
Accession:
GSE135303
ID:
200135303
2.

Comparative transcriptomics of Clostridium thermocellum wild type (Δhpt) and Type I glutamine synthetase (Clo1313_2031) deletion strains using RNA-seq

(Submitter supplied) RNA-seq analysis revealed that genes involved in urea uptake and metabolism were significantly upregulated in the Clo1313_2031 deletion strain, suggesting that deletion of Clo1313_2031 mimics nitrogen starvation in C. thermocellum. Additionally, genes encoding the RNF-complex were also more highly expressed and in turn may have a potential role in increasing ethanol production.
Organism:
Acetivibrio thermocellus DSM 1313
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20122
8 Samples
Download data: TXT, XLSX
Series
Accession:
GSE78219
ID:
200078219
3.

Transcriptional profiles of Haloferax mediterranei based on nitrogen availability

(Submitter supplied) Transcriptional profiling of Haloferax mediterranei in three culture media with different nitrogen sources: a) cells were grown stationary and exponentially on ammonium, b) cells were grown exponentially on nitrate, and c) cells were shifted to nitrogen starvation conditions. The main differences in the transcriptional profiles have been identified between the cultures with ammonium as nitrogen source and the cultures with nitrate or nitrogen starvation, supporting previous results which indicate the absence of ammonium as the factor causing the expression of genes involved in nitrate assimilation pathway.
Organism:
Haloferax mediterranei
Type:
Expression profiling by array
Platform:
GPL18892
8 Samples
Download data: TXT
Series
Accession:
GSE59551
ID:
200059551
4.

Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae

(Submitter supplied) Several genes involved in nitrogen metabolism are known to contribute to the virulence of pathogenic bacteria. Here, we studied the function of the nitrogen regulatory protein GlnR in the Gram-positive human pathogen Streptococcus pneumoniae. We demonstrate that GlnR mediates transcriptional repression of genes involved in glutamine synthesis and uptake (glnA, glnPQ), glutamate synthesis (gdhA), and the gene encoding the pentose phosphate pathway enzyme Zwf, which forms an operon with glnPQ. more...
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by array
Platforms:
GPL3882 GPL3881
6 Samples
Download data
Series
Accession:
GSE5088
ID:
200005088
5.

Are small RNAs involved in the regulation of nitrogen metabolism in haloarchaea?

(Submitter supplied) Small RNAs have been studied in detail in Bacteria and Eukarya domain, but in the case of Archaea domain the knowledge is scarce and the physiological function of the majority is still uncertain. To extend the knowledge of sRNAs in Archaea domain and its possible role in the regulation of the nitrogen assimilation metabolism in haloarchaea, Haloferax mediterranei has been used as a model microorganism. more...
Organism:
Haloferax mediterranei
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20667
15 Samples
Download data: GFF3, TXT
Series
Accession:
GSE108616
ID:
200108616
6.

Analysis of Lsm protein-mediated regulation in the haloarchaeon Haloferax mediterranei

(Submitter supplied) The transcriptional analysis of the HM26-ΔSm1 deletion mutant versus the parental strain HM26 was performed under nitrogen and carbon starvation for 120 h. These contrasts allow us to analyze the effect that the deletion of the Sm1 motif has under these conditions and, therefore, allow us to know which genes are regulated by the Lsm protein under the conditions analyzed.
Organism:
Haloferax mediterranei
Type:
Expression profiling by array
Platform:
GPL18892
8 Samples
Download data: TXT
Series
Accession:
GSE244624
ID:
200244624
7.

Transcriptomic profiling of haloarchaeal denitrification through RNA-Seq analysis

(Submitter supplied) Denitrification, a crucial biochemical pathway prevalent among haloarchaea in hypersaline ecosystems, has garnered considerable attention in recent years due to its ecological implications. Nevertheless, the underlying molecular mechanisms and genetic regulation governing this respiration/detoxification process in haloarchaea remain largely unexplored. In this study, RNA-sequencing was used to compare the transcriptomes of the haloarchaeon Haloferax mediterranei under oxic and denitrifying conditions, shedding light on the intricate metabolic alterations occurring within the cell such as the accurate control of the metal homeostasis. more...
Organism:
Haloferax mediterranei
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20667
6 Samples
Download data: TXT
Series
Accession:
GSE245042
ID:
200245042
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