GEO DataSets

(Submitter supplied) We used transposon insertion sequencing (Tn-Seq) to identify the genes that are required for in vitro growth and intramacrophage growth of the live vaccine strain of F. tularensis (LVS).

Organism:

Francisella tularensis subsp. holarctica LVS

Type:

Other

Platform:

GPL27588

5 Samples

Download data: WIG

(Submitter supplied) Francisella tularensis is a Gram-negative bacterium that causes a fatal human disease known as tularemia. The Centers for Disease Control have classified F. tularensis as Category A Tier-1 Select Agent. The virulence mechanisms of Francisella are not entirely understood. Francisella possesses very few transcription regulators, and most of these regulate the expression of genes involved in intracellular survival and virulence. more...

Organism:

Francisella tularensis subsp. holarctica LVS

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23586

12 Samples

Download data: XLS

(Submitter supplied) Virulent Francisella tularensis induces a unique pulmonary inflammatory response characterized by temporal regulation of innate immune pathways correlating with altered bacterial gene expression patterns.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

63 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of LVS grown in hepatocytic cell line FL83B was compared to that of LVS cultued in MH broth to discover genes important for intracellular growth.

Organism:

Francisella tularensis; Francisella tularensis subsp. holarctica LVS

Type:

Expression profiling by array

Platform:

GPL4250

4 Samples

Download data: GPR

(Submitter supplied) The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are necessary for replication in macrophages and for virulence in mice. We hypothesized that identification of MglA-regulated genes in the Francisella genome by transcriptional profiling of wild-type and mglA mutant bacteria would lead to the discovery of new virulence factors utilized by F. more...

Organism:

Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL4062

34 Samples

Download data

(Submitter supplied) These microarray studies are part of a larger study characterizing a deletion mutant of the putative transcriptional regulator IclR in Francisella tularensis LVS and SchuS4 strains. The microarrays were performed using RNA isolated from wild-type LVS and a LVS iclR deletion mutant after growing in Chamberlain?s defined media pH 6.3 to early mid-log phase. Results suggest that IclR affects expression of several genes after determining statistically significant differences by SAM.

Organism:

Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL5844

6 Samples

Download data: GPR, MEV