GEO DataSets

(Submitter supplied) Candida albicans is a member of the normal commensal flora with the ability to cause disease in susceptible individuals. Nutrient acquisition is of central importance for C. albicans to colonize and thrive in the host. We have previously assessed the role of amino acid utilization for growth and manipulation of pH, triggering the filamentation program and promoting immune evasion. While the role of amino acids has been largely studied, protein utilization has remained less well understood. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28174

27 Samples

Download data: TXT

(Submitter supplied) Purpose: Candida albicans avidly uses multiple carbon sources that are less preferred by related species. This project compared transcriptional profiles of cells growing in media containing these nutrients relative to glucose Methods: C. albicans strain SC5314 was incubated in minimal YNB media containing 2% glucose, casamino acids, glutamate or a-ketoglutarate for five hours. RNA was prepared and subjected to deep sequencing. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15645

8 Samples

Download data: TXT

(Submitter supplied) The goals of this study were to identify the Efg1p-regulon during GI tract colonization and to compare C. albicans gene expression during colonization of different organs of the GI tract. Our results identified significant differences in gene expression between cells colonizing the cecum and ileum. In addition, during laboratory growth, efg1- null mutant cells grew to a higher density than WT cells. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL9818

44 Samples

Download data: TXT

(Submitter supplied) We employed RNA-Seq to identify ZCF8-dependent and ZCF8-indepenent transcriptional changes in Candida albicans cells treated with nigericin.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28323

8 Samples

Download data: CSV, TXT

(Submitter supplied) We employed RNA-Seq to identify targets of regulation of the transcription regualtor ZCF8 in nitrogen-starved Candida albicans cells.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28323

6 Samples

Download data: CSV, TXT

(Submitter supplied) We employed ChIP-Seq to identiy direct targets of regulation of the Candida albicans transcription regulator Zcf8p.

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL15645

12 Samples

Download data: TXT

(Submitter supplied) Candida albicans is the most common opportunistic fungal pathogen of humans and is also a benign member of the gastrointestinal (GI) tract microbiota. Morphological transitions and metabolic regulation are critical for C. albicans to adapt to the changing host environment. We generated a library of central metabolic pathway mutants in the tricarboxylic acid (TCA) cycle, and investigated the functional consequences of these gene deletions on C. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15645

8 Samples

Download data: XLS

(Submitter supplied) Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. This suppleness requires an effective mechanism to reprogram reversibly the primary metabolism in response to oxygen variation. Here, we have uncovered that Snf5, a subunit of SWI/SNF chromatin remodeling complex, is a major transcriptional regulator that links oxygen status to the metabolic capacity of C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL9818

4 Samples

Download data: TXT

(Submitter supplied) To determine potential roles of three transcript factors (Rbf1p, Hfl1p and Dpb4p) in cell metabolic activities and other cellular bioprocesses, we have performed genomic microarray in each gene knockout strain and transcription profiles were compared to its parental strain SN250

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL18166

4 Samples

Download data: TXT

(Submitter supplied) Transcriptome profiling to identify Cap2/Hap43 regulons in the human fungal pathogen Candida albicans: Wild type vs. cap2D grown in iron-depleted medium

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL4758

4 Samples

Download data: GPR

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL17892

2 Samples

Download data: GPR

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL19932

16 Samples

Download data: GPR

(Submitter supplied) The regulatory mechanisms during biofilm aging were determined using RNA-seq of C. albicans biofilms from three time points. The role of oxygen was investigated by comparing normoxic and hypoxic grown biofilms. Since nutrient uptake is important during biofilm maturation, the transcriptome of a stp2Δ strain lacking proper amino acid uptake was compared to the wild-type parent strain.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15645

36 Samples

Download data: CSV

(Submitter supplied) LYS142, LYS143, LYS14 and LYS144 compose a family of recently duplicated transcription regulators in C. albicans. They have differentiated from one another by acquiring a largely separate set of target genes. Chromatin immunoprecipitation (ChIP) of GFP-LYS142, GFP-LYS143, GFP-LYS14 and GFP-LYS144 followed by array hybridization (Agilent) uncovered a network of target genes controlled by these regulators in the yeast C. more...

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL17892

5 Samples

Download data: GPR