Similar studies for GEO DataSets (Select 200147880) - GEO DataSets

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Items: 16

Select item 2001478801.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [sputum]

(Submitter supplied) Severe asthma is a heterogeneous disease. Transcriptomic analysis contributes to understanding the driver mechanisms necessary for developing new therapies. The aim of this study was to identify mechanistic pathways of severe asthma across two independent cohorts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
44 Samples

Download data: TXT

Series

Accession:: GSE147880

ID:: 200147880

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001478812.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6104 GPL10558
117 Samples

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Series

Accession:: GSE147881

ID:: 200147881

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Select item 2001478783.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [biopsy]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
73 Samples

Download data: TXT

Series

Accession:: GSE147878

ID:: 200147878

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Select item 2001131854.

IL-6 trans-signaling induced gene expression in airway epithelial cells

(Submitter supplied) Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. Objective: To explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma. Methods: Primary human bronchial epithelial cell (HBEC) air-liquid interface (ALI) cultures were stimulated with IL-6 and sIL-6R to establish an IL-6TS gene signature. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: TXT

Series

Accession:: GSE113185

ID:: 200113185

Select item 2000762625.

Expression data of induced sputum from Unbiased BIOmarkers in Prediction of REspiratory Disease outcomes (U-BIOPRED) Project

(Submitter supplied) Asthma is a heterogeneous disease requiring understandings at molecular level that characterizes subgroups of patients with specific biomarkers to faciliate the development of targeted thearpies. We used Affymetrix U133 Plus 2.0 PM only arrays to explore the gene expression profile from induced sputum cells of 118 moderate/severe asthmatic patients and 21 healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
139 Samples

Download data: CEL

Series

Accession:: GSE76262

ID:: 200076262

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Select item 2000380036.

Transcriptomic Analysis of Airway Smooth Muscle by Next-Generation Sequencing (RNA-Seq): Asthma versus Healthy Controls

(Submitter supplied) Rationale: Asthma and atopy shares common features including Th2-inflammation. However, impairment of airway function seems to be absent in atopy. Increased understanding of the complex cellular and molecular pathways defining the similarities and differences between asthma and atopy may be achieved by transcriptomic analysis (RNA-Seq). Hypothesis and Aims: As the airway smooth muscle (ASM) layer plays an important role in airway function, we hypothesized that the transcriptomic profile of the ASM layer in endobronchial biopsies is different between atopic asthma patients and atopic healthy controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14603
24 Samples

Download data: CSV

Series

Accession:: GSE38003

ID:: 200038003

Select item 2000433977.

Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma

(Submitter supplied) Systemic inflammation is reported to be associated with neutrophilic airway inflammation in asthma, this study aimed to examine the molecular mechanisms of the neutrophilia that is associated with systemic inflammation, and hypothesized that asthma patients with systemic inflammation have a group of genes that are differentially expressed and are assciated with airway inflammation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
50 Samples

Download data: TXT

Series

Accession:: GSE43397

ID:: 200043397

Select item 2000451118.

A sputum gene expression signature of six biomarkers identifies asthma inflammatory phenotype and steroid responsiveness

(Submitter supplied) This study identifies differentially expression genes in the sputum of people with eosinophilic, neutrophilic and paucigranulocytic asthma. A selection of markers identified using this microarray were further validated using qPCR on a wider sample set.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
47 Samples

Download data: TXT

Series

Accession:: GSE45111

ID:: 200045111

Select item 2000584309.

Transcriptomic profiling of peripheral blood CD4+ T cells in asthmatics with and without depression

(Submitter supplied) The aim of this study was to determine whether asthma with depression is characterized by unique pathophysiological pathways by analyzing the global gene expression patterns of CD4+ lymphocytes from asthmatics with or without depression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
24 Samples

Download data: TXT

Series

Accession:: GSE58430

ID:: 200058430

Select item 20024560810.

Transcriptomic evaluation of skin tape-strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma-associated biomarkers abnormalities

(Submitter supplied) Tape-strips were obtained from skin of 18 pediatric patients with moderate allergic asthma (MAA) (n=11), severe allergic asthma (SAA) (n=9), and from healthy children (n=12) and analyzed with bulk RNA-sequencing (RNA-seq). Differential expression was defined as |fold change|≥2 and false discovery rate<0.05. MAA and SAA shared downregulation of G-protein-coupled receptor- (GPCR), mitochondria-, and Wnt-signaling-related genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24014
32 Samples

Download data: CSV

Series

Accession:: GSE245608

ID:: 200245608

Select item 20008980911.

Multi-tissue transcriptomics delineates the diversity of airway T cells functions in asthma

(Submitter supplied) Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues including epithelial and T cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
145 Samples

Download data: CEL

Series

Accession:: GSE89809

ID:: 200089809

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Select item 20006968312.

Expression profiling in blood from subjects with severe asthma, moderate asthma, and non-asthmatics collected in the U-BIOPRED study

(Submitter supplied) Severe asthma is a collection of disease entities with varying pathophysiological characteristics (7) that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project was set up as a public-private partnership within the framework of the Innovative Medicines Initiative (IMI), engaging academia, the pharmaceutical industry and patient groups. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
498 Samples

Download data: CEL

Series

Accession:: GSE69683

ID:: 200069683

Select item 20003899413.

Next-Generation Transcriptome Sequencing (RNA-Seq) of Human Endobronchial Biopsies: Asthma vs Controls

(Submitter supplied) Rationale: The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). Hypothesis and Aims: We hypothesized that the transcriptomic profile of whole human endobronchial biopsies differs between patients with asthma and controls. First, we investigated the feasibility to obtain RNA from whole endobronchial biopsies suitable for RNA-Seq. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14603
2 Samples

Download data: CSV

Series

Accession:: GSE38994

ID:: 200038994

PubMed Similar studies SRA Run Selector

Select item 20005865714.

Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

(Submitter supplied) Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimulation of human ASM cell proliferation. Objective: To investigate the effect of S1P on signalling and regulation of gene expression in ASM cells from healthy and asthmatic individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
6 Samples

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Series

Accession:: GSE58657

ID:: 200058657

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Select item 20017249515.

SINGLE-CELL CHARACTERIZATION OF A MODEL OF POLY I:C-STIMULATED PERIPHERAL BLOOD MONONUCLEAR CELLS IN SEVERE ASTHMA

(Submitter supplied) Background: Asthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may be responsible for asthma immunopathology. However, existing models to study the immune response in asthma are limited by bulk profiling of cells. Our objective was to Characterize a model of peripheral blood mononuclear cells (PBMCs) of patients with severe asthma (SA) and its response to the TLR3 agonist Poly I:C using two single-cell methods. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
16 Samples

Download data: CSV

Series

Accession:: GSE172495

ID:: 200172495

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005639616.

Non-invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma

(Submitter supplied) Evaluation of the airway transcriptome may reveal patterns of gene expression that are associated with clinical phenotypes of asthma. To define transcriptomic endotypes of asthma (TEA) we analyzed gene expression in induced sputum that correlate with phenotypes of disease. Gene expression was measured in sputum of subjects with asthma using Affymetrix HuGene ST 1.0 microarrays. Unsupervised clustering analysis of genes identified TEA clusters. more...