Similar studies for GEO DataSets (Select 200154138) - GEO DataSets - NCBI

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Items: 20

Select item 2001541381.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (MeRIP-Seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
12 Samples

Download data: BW

Series

Accession:: GSE154138

ID:: 200154138

PubMed Similar studies SRA Run Selector

Select item 2001601032.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-Seq 3)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
4 Samples

Download data: BW

Series

Accession:: GSE160103

ID:: 200160103

PubMed Similar studies SRA Run Selector

Select item 2001541393.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (total RNA-Seq 2)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: BW

Series

Accession:: GSE154139

ID:: 200154139

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Select item 2001541374.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIRP-Seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
2 Samples

Download data: BW

Series

Accession:: GSE154137

ID:: 200154137

PubMed Similar studies SRA Run Selector

Select item 2001541355.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-Seq 2)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
62 Samples

Download data: BW

Series

Accession:: GSE154135

ID:: 200154135

PubMed Similar studies SRA Run Selector

Select item 2001451356.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs [YTHDC1_ChIP]

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
7 Samples

Download data: BW

Series

Accession:: GSE145135

ID:: 200145135

PubMed Similar studies SRA Run Selector

Select item 2001451347.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs [YTHDC1_ChIRP-Seq]

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
2 Samples

Download data: BW

Series

Accession:: GSE145134

ID:: 200145134

PubMed Similar studies SRA Run Selector

Select item 2001262438.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:: GPL21273
147 Samples

Download data: BW, TXT

Series

Accession:: GSE126243

ID:: 200126243

PubMed Similar studies

Select item 2001262429.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (total RNA-seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
8 Samples

Download data: BW

Series

Accession:: GSE126242

ID:: 200126242

PubMed Similar studies SRA Run Selector

Select item 20012623910.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (WGBS)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21273
8 Samples

Download data: TXT

Series

Accession:: GSE126239

ID:: 200126239

PubMed Similar studies SRA Run Selector

Select item 20012623811.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
36 Samples

Download data: BW

Series

Accession:: GSE126238

ID:: 200126238

PubMed Similar studies SRA Run Selector

Select item 20015600712.

m6A methylation regulates the fate of endogenous retrovirus transcripts [CUT & RUN]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
14 Samples

Download data: BW

Series

Accession:: GSE156007

ID:: 200156007

PubMed Similar studies SRA Run Selector

Select item 20014561613.

m6A methylation regulates the fate of endogenous retrovirus transcripts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL17021
45 Samples

Download data: BW, TXT

Series

Accession:: GSE145616

ID:: 200145616

PubMed Similar studies

Select item 20014561514.

m6A methylation regulates the fate of endogenous retrovirus transcripts [CRISPR/Cas9]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL17021
13 Samples

Download data: TSV

Series

Accession:: GSE145615

ID:: 200145615

PubMed Similar studies SRA Run Selector

Select item 20014531515.

m6A methylation regulates the fate of endogenous retrovirus transcripts [RIP-seq]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: BW

Series

Accession:: GSE145315

ID:: 200145315

PubMed Similar studies SRA Run Selector

Select item 20014530916.

m6A methylation regulates the fate of endogenous retrovirus transcripts [RNA-seq]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: TXT

Series

Accession:: GSE145309

ID:: 200145309

PubMed Similar studies SRA Run Selector

Select item 20007778117.

Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL18480
40 Samples

Download data: WIG

Series

Accession:: GSE77781

ID:: 200077781

PubMed Similar studies

Select item 20007778018.

Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing [RRBS-seq]

(Submitter supplied) Genetic ablation of the maintenance methyltransferase Dnmt1 induces widespread demethylation and transcriptional activation of CpG-rich IAP (intracisternal A particle) proviruses. Here, we report that this phenomenon is not simply a consequence of loss of DNA methylation. By exploiting conditional deletions of Dnmt1 and Np95, each of which is essential for maintenance methylation, we find that while IAPs are indeed de-repressed in Dnmt1-ablated embryos and embryonic stem cells (ESCs), these proviruses remain silenced in Np95-ablated cells, despite similar kinetics of passive demethylation. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18480
5 Samples

Download data: TXT

Series

Accession:: GSE77780

ID:: 200077780

PubMed Similar studies SRA Run Selector

Select item 20007777919.

Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing [ChIP-seq]

(Submitter supplied) Genetic ablation of the maintenance methyltransferase Dnmt1 induces widespread demethylation and transcriptional activation of CpG-rich IAP (intracisternal A particle) proviruses. Here, we report that this phenomenon is not simply a consequence of loss of DNA methylation. By exploiting conditional deletions of Dnmt1 and Np95, each of which is essential for maintenance methylation, we find that while IAPs are indeed de-repressed in Dnmt1-ablated embryos and embryonic stem cells (ESCs), these proviruses remain silenced in Np95-ablated cells, despite similar kinetics of passive demethylation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18480
9 Samples

Download data: WIG

Series

Accession:: GSE77779

ID:: 200077779

PubMed Similar studies SRA Run Selector

Select item 20007777820.

Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing [RNA-seq]

(Submitter supplied) Genetic ablation of the maintenance methyltransferase Dnmt1 induces widespread demethylation and transcriptional activation of CpG-rich IAP (intracisternal A particle) proviruses. Here, we report that this phenomenon is not simply a consequence of loss of DNA methylation. By exploiting conditional deletions of Dnmt1 and Np95, each of which is essential for maintenance methylation, we find that while IAPs are indeed de-repressed in Dnmt1-ablated embryos and embryonic stem cells (ESCs), these proviruses remain silenced in Np95-ablated cells, despite similar kinetics of passive demethylation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
26 Samples

Download data: TXT

Series

Accession:: GSE77778

ID:: 200077778

PubMed Similar studies SRA Run Selector

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