Similar studies for GEO DataSets (Select 200156007) - GEO DataSets

Select item 2001560071.

m6A methylation regulates the fate of endogenous retrovirus transcripts [CUT & RUN]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
14 Samples

Download data: BW

Series

Accession:: GSE156007

ID:: 200156007

PubMed Similar studies SRA Run Selector

Select item 2001456162.

m6A methylation regulates the fate of endogenous retrovirus transcripts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL17021
45 Samples

Download data: BW, TXT

Series

Accession:: GSE145616

ID:: 200145616

PubMed Similar studies

Select item 2001456153.

m6A methylation regulates the fate of endogenous retrovirus transcripts [CRISPR/Cas9]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL17021
13 Samples

Download data: TSV

Series

Accession:: GSE145615

ID:: 200145615

PubMed Similar studies SRA Run Selector

Select item 2001453154.

m6A methylation regulates the fate of endogenous retrovirus transcripts [RIP-seq]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: BW

Series

Accession:: GSE145315

ID:: 200145315

PubMed Similar studies SRA Run Selector

Select item 2001453095.

m6A methylation regulates the fate of endogenous retrovirus transcripts [RNA-seq]

(Submitter supplied) Using a genome-scale CRISPR knockout screening in mouse embryonic stem cells, we identify m6A RNA methylation as an important regulatory component that restricts the activity of endogenous retroviruses of the IAP (intracisternal A-particles) family. The m6A methylation of IAP mRNAs occurs on their 5’ end, is catalyzed by the complex of methyltransferase-like (METTL)3/METTL14 proteins whose depletion, along with other complex subunits, namely WTAP and ZC3H13, leads to increased IAP transcript abundance. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: TXT

Series

Accession:: GSE145309

ID:: 200145309

PubMed Similar studies SRA Run Selector

Select item 2001601036.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-Seq 3)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
4 Samples

Download data: BW

Series

Accession:: GSE160103

ID:: 200160103

PubMed Similar studies SRA Run Selector

Select item 2001541397.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (total RNA-Seq 2)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: BW

Series

Accession:: GSE154139

ID:: 200154139

PubMed Similar studies SRA Run Selector

Select item 2001541388.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (MeRIP-Seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
12 Samples

Download data: BW

Series

Accession:: GSE154138

ID:: 200154138

PubMed Similar studies SRA Run Selector

Select item 2001541379.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIRP-Seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
2 Samples

Download data: BW

Series

Accession:: GSE154137

ID:: 200154137

PubMed Similar studies SRA Run Selector

Select item 20015413510.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-Seq 2)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
62 Samples

Download data: BW

Series

Accession:: GSE154135

ID:: 200154135

PubMed Similar studies SRA Run Selector

Select item 20014513511.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs [YTHDC1_ChIP]

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
7 Samples

Download data: BW

Series

Accession:: GSE145135

ID:: 200145135

PubMed Similar studies SRA Run Selector

Select item 20014513412.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs [YTHDC1_ChIRP-Seq]

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL21273
2 Samples

Download data: BW

Series

Accession:: GSE145134

ID:: 200145134

PubMed Similar studies SRA Run Selector

Select item 20012624313.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:: GPL21273
147 Samples

Download data: BW, TXT

Series

Accession:: GSE126243

ID:: 200126243

PubMed Similar studies

Select item 20012624214.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (total RNA-seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
8 Samples

Download data: BW

Series

Accession:: GSE126242

ID:: 200126242

PubMed Similar studies SRA Run Selector

Select item 20012623915.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (WGBS)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21273
8 Samples

Download data: TXT

Series

Accession:: GSE126239

ID:: 200126239

PubMed Similar studies SRA Run Selector

Select item 20012623816.

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (ChIP-seq)

(Submitter supplied) N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in heterochromatin integrity regulation in mouse embryonic stem cells (mESCs). We show that in mESCs METTL3 predominantly localizes to one of the most active endogenous retroviruses (ERVs) families, the intracisternal A-type particles (IAPs). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
36 Samples

Download data: BW

Series

Accession:: GSE126238

ID:: 200126238

PubMed Similar studies SRA Run Selector

Select item 20009414817.

A novel RNA m6A modulator Zc3h13 plays an anchor role in facilitating nuclear RNA methylation and mouse embryonic stem cell self-renewal

(Submitter supplied) N6-methyladenosine (m6A) is an abundant modification in eukaryotic mRNA, regulating mRNA dynamics by influencing mRNA stability, splicing, export and translation. Recent studies discovered m6A methyltransferases (?writer?), demethylases (?eraser?) and binding proteins (?reader?), which modulate m6A methylation. However, the precise m6A regulating machinery still remains incompletely understood. Here we demonstrate that ZC3H13, a zinc finger protein, plays an essential role in modulating m6A methylation on polyadenylated RNA in the nucleus. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21273 GPL17021
34 Samples

Download data: BED, BEDGRAPH, TXT

Series

Accession:: GSE94148

ID:: 200094148

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010086418.

SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data

Series

Accession:: GSE100864

ID:: 200100864

PubMed Full text in PMC Similar studies

Select item 20009825619.

Rif1 Promotes a Repressive Chromatin State to Safeguard Against Endogenous Retrovirus Activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL19057
22 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE98256

ID:: 200098256

PubMed Full text in PMC Similar studies

Select item 20009825520.

Rif1 Promotes a Repressive Chromatin State to Safeguard Against Endogenous Retrovirus Activation [RNA-seq]

(Submitter supplied) Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their repression are not fully understood. To systematically study ERV repression, we carried out an RNAi screen in mouse embryonic stem cells (ESCs) and identified a list of novel regulators. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE98255

ID:: 200098255

PubMed Full text in PMC Similar studies SRA Run Selector

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