RNA-Seq to investigate gene expression in M. bovis BCG subjected to darG depletion or DNA damage induction with mitomycin D - - GEO DataSets

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RNA-Seq to investigate gene expression in M. bovis BCG subjected to darG depletion or DNA damage induction with mitomycin D

(Submitter supplied) M. bovis BCG bacilli were subjected to silencing of the darG antitoxin gene by CRISPRI, leading to unregulated activity of the toxin DarT. This results in ADP-ribosylation of specific motifs in genomic DNA, and induction of the DNA damage response. The goal of this study is to compare gene expression of M. bovis BCG in untreated, DarG-depleted, and mitomycin treated samples.

Organism:: Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30131
9 Samples

Download data: TXT

Series

Accession:: GSE174526

ID:: 200174526

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