Similar studies for GEO DataSets (Select 200175598) - GEO DataSets

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Items: 20

Select item 2001755981.

Defining the mammalian coactivation of hepatic 12-hour clock and lipid metabolism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
43 Samples

Download data: BIGWIG

Series

Accession:: GSE175598

ID:: 200175598

PubMed Full text in PMC Similar studies

Select item 2001755602.

Time course hepatic RNA-Seq in the SRC-3 WT versus KO mice

(Submitter supplied) We report the hepatic total gene expression (starting at ZT0 and proceeding every four hours for two complete 12-hour cycles) in the liver of SRC-3 WT and KO mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
12 Samples

Download data: BIGWIG

Series

Accession:: GSE175560

ID:: 200175560

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001755593.

Time course SRC-3 ChIP-Seq and XBP1s ChIP-Seq in the C57BJ/L6 WT, SRC-3 WT versus KO, and Xbp1 WT versus LKO mice under chow and fasting conditions

(Submitter supplied) We report the hepatic SRC-3 and XBP1s cistrome at 4-hour interval timecourse zeitgeber times (ZTs) in the liver of the C57BJ/L6 WT mice under chow and fasting conditions; we also chose liver samples at CT24, ZT0 and ZT8 for comprehensive SRC-3 and XBP1s ChIP-Seq to interrogate the genomic binding profiles of hepatic SRC-3 and XBP1s in vivo.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
31 Samples

Download data: BIGWIG

Series

Accession:: GSE175559

ID:: 200175559

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Select item 2001508904.

Time course Total RNA-Seq and XBP1s ChIP-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre;Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
113 Samples

Download data: BIGWIG

Series

Accession:: GSE150890

ID:: 200150890

PubMed Full text in PMC Similar studies

Select item 2001508885.

Time course Total RNA-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre;Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice

(Submitter supplied) We reported the hepatic total gene expression (starting at CT0 and proceeding every two hours for four complete 12-hour cycles) in the liver of wild-type mice and XBP1 liver-specific knockout mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
96 Samples

Download data: BIGWIG

Series

Accession:: GSE150888

ID:: 200150888

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Select item 2000530396.

Genome-wide Profiling of Steroid Receptor Coactivator 2 in mouse liver

(Submitter supplied) Steroid Receptor 2 (SRC-2) is a coactivator involved in hepatic metabolism. To better understand its temporal involvement in metabolism genome wide profiling was performed at 2 time ZT4 and ZT18 as well as in the SRC-2 knockout mouse.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9250
4 Samples

Download data: BW

Series

Accession:: GSE53039

ID:: 200053039

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001999987.

Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

(Submitter supplied) Diurnal (i.e., 24-hour) physiological rhythms depend on transcriptional programs controlled by a set of circadian clock genes/proteins. Systemic factors like humoral and neuronal signals, oscillations in body temperature, and food intake align physiological circadian rhythms with external time. Thyroid hormones (THs) are major regulators of circadian clock target processes such as energy metabolism, but little is known about how fluctuations in TH levels affect the circadian coordination of tissue physiology. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
70 Samples

Download data: CEL

Series

Accession:: GSE199998

ID:: 200199998

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000340208.

Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL9250 GPL6885
27 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE34020

ID:: 200034020

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000340199.

Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [ChIP_seq]

(Submitter supplied) The circadian clock acts at the genomic level to coordinate internal behavioral and physiologic rhythms via the CLOCK-BMAL transcriptional heterodimer. Although the nuclear receptors REV-ERBα and β have been proposed to contribute to clock function, their precise roles and importance remain unresolved. To establish their regulatory potential we generated comparative cistromes of both Rev-erb isoforms, which revealed shared recognition at over ~50% of their total sites and extensive overlap with the master clock regulator Bmal. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9250
3 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE34019

ID:: 200034019

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Select item 20003401810.

Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [Expression array]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
24 Samples

Download data: TXT

Series

Accession:: GSE34018

ID:: 200034018

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018430311.

Next Generation RNA Sequencing - Delineation of Hepatic Transcriptome Governed by Liver Clock and Gut Microbes over Time

(Submitter supplied) We report the application of bulk RNA-sequencing-based technology for high-throughput profiling to examine the individual and combinatorial effects of the liver circadian clock and gut microbes on the liver transcriptome over 24-hours. Principle Component Analysis demonstrated that functionality of the liver circadian clock is the primary driver of the hepatic transcriptome profile, and presence of microbes is the secondary driver. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
72 Samples

Download data: TXT

Series

Accession:: GSE184303

ID:: 200184303

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Select item 20010865012.

Bmal1 and Rev-erb⍺ cistromes in skeletal muscle

(Submitter supplied) We mapped the genome-wide binding profiles of BMAL1 and REV-ERB⍺ during peak protein expression of each factor (ZT4, and ZT8, respectively) by ChIP-Seq in gastrocnemius muscles from control C57BL/6J mice.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL21103
7 Samples

Download data: BEDGRAPH, NARROWPEAK

Series

Accession:: GSE108650

ID:: 200108650

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Select item 20011896713.

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

(Submitter supplied) Virtually every mammalian tissue exhibits rhythmic expression in thousands of genes, which activate tissue-specific processes at appropriate times of the day. Much of this rhythmic expression is thought to be driven cell-autonomously by molecular circadian clocks present throughout the body. However, increasing evidence suggests that systemic signals, and more specifically rhythmic food intake (RFI), can regulate rhythmic gene expression independently of the circadian clock. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
72 Samples

Download data: TXT

Series

Accession:: GSE118967

ID:: 200118967

PubMed Similar studies SRA Run Selector

Select item 20014969814.

Systematic analysis of differential rhythmic gene expression mediated by the circadian clock and feeding rhythms in mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
120 Samples

Download data

Series

Accession:: GSE149698

ID:: 200149698

PubMed Full text in PMC Similar studies

Select item 20013589815.

Temporal profiles of gene expression in Cry1/2 KO, Bmal1 KO under night restricted feeding and ad libitum feeding regimen

(Submitter supplied) The circadian clock and rhythmic food intake are both important regulators of rhythmic gene expression in the liver. It remains, however, elusive to which extent the circadian clock network and natural feeding rhythms contribute to rhythmic gene expression. To systematically address this question, we developed an algorithm to investigate differential rhythmicity between a varying number of conditions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
96 Samples

Download data: TXT

Series

Accession:: GSE135898

ID:: 200135898

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Select item 20013587516.

Temporal profiles of hepatic gene expression in PAR bZip triple knockout mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: TXT

Series

Accession:: GSE135875

ID:: 200135875

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015913517.

Feeding differentially regulates clocks and rhythmicity of peripheral tissues through the liver-clock

(Submitter supplied) The mammalian circadian system consists of a central clock in the brain that synchronizes clocks in peripheral tissues. While the hierarchy between the central and peripheral clocks is well established, peripheral clocks are largely viewed as a group and little is known regarding their specificity and functional organization. We employed feeding paradigms in conjunction with liver-specific clock-deficient murine model to map disparities and potential interactions between peripheral clocks. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
288 Samples

Download data: XLSX

Series

Accession:: GSE159135

ID:: 200159135

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20021893218.

Transcriptomic differences in livers from pubertal mice fed the AIN93G standard diet or a high-fat diet

(Submitter supplied) The analyses show that consumption of a high-fat diet, compared to a standard control diet, alters hepatic transcriptome in pubertal mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
42 Samples

Download data: XLS

Series

Accession:: GSE218932

ID:: 200218932

PubMed Full text in PMC Similar studies

Select item 20022965619.

Class 3 PI3K participates in nuclear gene transcription and co-activates the circadian clock to promote de novo purine synthesis [ChIP-seq]

(Submitter supplied) Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient sensing signaling pathways, yet mechanisms of their interaction remain not fully understood. Here, surprisingly, we find that class 3 Phosphatidylinositol-3-kinase (PI3K), known best for its essential role as a lipid kinase in endocytosis and lysosomal degradation by autophagy, has an overlooked nuclear function in participating to gene transcription as a co-activator of heterodimeric transcription factor and circadian driver BMAL1-CLOCK. more...