GEO DataSets

(Submitter supplied) Transcriptomic analysis of S. maltophilia D457 after one-hour induction with the antibiotic fosfomycin, the intermediate metabolites phosphoenolpyruvate or glyceraldehyde-3-phosphate

Organism:

Stenotrophomonas maltophilia

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30504

13 Samples

Download data: TXT

(Submitter supplied) Fosfomycin is a bactericidal antibiotic, analogous to phosphoenolpyruvate (PEP) that exerts its activity by inhibiting the activity of MurA. This enzyme catalyzes the first step of peptidoglycan biosynthesis, the transfer of enolpyruvate from PEP to uridine- diphosphate-N-acetylglucosamine. Fosfomycin is increasingly used in the last years, mainly for treating infections caused by Gram-negative multidrug resistant bacteria as Stenotrophomonas maltophilia, an opportunistic pathogen characterized by its low susceptibility to antibiotics of common use. more...

Organism:

Stenotrophomonas maltophilia

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25680

5 Samples

Download data: XLS

(Submitter supplied) We characterized the transcriptional responses of three S. maltophilia strains during exposure to synthetic CF sputum media (SCFM2) to gain insight into how this organism interacts with the host in the CF lung. These efforts led to the identification of 881 transcripts differentially expressed by all three strains, many of which reflect different metabolic pathways used by S. maltophilia in sputum, and altered stress responses. more...

Organism:

Stenotrophomonas maltophilia

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23835

12 Samples

Download data: CSV

(Submitter supplied) Staphylococcus aureus is a highly adaptable human pathogen; therefore a constant search for new effective antibiotic compounds is being preformed. Gene expression profiling can be used to determine potential targets and mechanisms of action (MOA) of known or potential drugs. The goal of our study was a development of a focused transcriptome platform to be used for confirming the MOA of new chemical entities which are designed as inhibitors of Mur ligases. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

37 Samples

Download data: CEL, CHP