Similar studies for GEO DataSets (Select 200183003) - GEO DataSets

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Items: 3

Select item 2001830031.

Gene expression profiling in Nlrp3 deficient mice infected with Francisella tularensis

(Submitter supplied) This study investigated gene expression profile in wild type and nlrp3 deficient mice infected with F. tularensis LVS. RNA-sequencing was performed to determine the transcript levels of genes using total RNA extracted from lungs of wild type C57BL/6 and Nlrp3-/- mice infected with 1 × 104 CFU of F. tularensis LVS on days 3 and 7 post-infection.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
12 Samples

Download data: XLS

Series

Accession:: GSE183003

ID:: 200183003

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001830012.

An AraC/XylS Family Transcriptional Regulator Modulates the Oxidative Stress Response of Francisella tularensis

(Submitter supplied) Francisella tularensis is a Gram-negative bacterium that causes a fatal human disease known as tularemia. The Centers for Disease Control have classified F. tularensis as Category A Tier-1 Select Agent. The virulence mechanisms of Francisella are not entirely understood. Francisella possesses very few transcription regulators, and most of these regulate the expression of genes involved in intracellular survival and virulence. more...

Organism:: Francisella tularensis subsp. holarctica LVS

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23586
12 Samples

Download data: XLS

Series

Accession:: GSE183001

ID:: 200183001

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000664613.

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(Submitter supplied) Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear. Here we found that the transcription factor IRF1 was required for the activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida), whereas engagement of the AIM2 inflammasome by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require IRF1. more...