GEO DataSets

(Submitter supplied) Deficiency in the X-linked inhibitor of apoptosis protein (XIAP) is the cause for the X-linked lymphoproliferative syndrome 2 (XLP2). About one third of all patients suffers from severe and therapy refractory inflammatory bowel disease (IBD), but the exact pathogenesis remains undefined. We examined the differences in gene expression of pediatric XLP2 patients with IBD to healthy controls and pediatric IBD patients.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

30 Samples

Download data: TXT

(Submitter supplied) Spontaneous inflammation in the terminal ileum of Xiap–/– mice was observed to occur in a microbiome dependent manner. Xiap–/– mice housed alone presented with signs of inflammation which were alleviated upon co-housing the mice with wild-type counterparts. To elucidate the impact of co-housing, and thus the transfer of the microbiome to affected Xiap–/– mice, crypts from the small intestine of these mice were analyzed.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

20 Samples

Download data: TXT

(Submitter supplied) We analyzed expression changes between JAK2V617F positive bone marrow cells and JAK2V617F negative cells We further analyzed how TNF receptor (receptor 1 or receptor 2) block influenced these changes in JAKV617F positive relative to JAK2V617F negative

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) The specific contribution of the two TNF-receptors Tnfr1 and Tnfr2 to TNF-induced inflammation in the glomerulus is unknown. In mice, TNF exposure induces glomerular expression of inflammatory mediators like adhesion molecules and chemokines in vivo, and glomerular accumulation of leukocytes. To examine Tnfr-specific inflammatory responses in intrinsic glomerular cells but not infiltrating leukocytes we performed microarray gene expression profiling on intact glomeruli isolated from wild-type and Tnfr-deficient mice following TNF exposure in vitro.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, CHP

(Submitter supplied) Caspase-8 is a cystein protease involved in regulating apoptosis. The function of caspase-8 was studied in the intestinal epithelium, using mice with an intestinal epithelial cell specific deletion of caspase-8. We used microarrays to investigate the difference of the global programme of gene expression in intestinal epithelial cells of control and caspase-8 deficient mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5182

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

Analysis of intestinal epithelial cells from animals with an intestinal epithelium specific deletion of caspase-8, a cysteine protease involved in regulating cellular apoptosis. Results provide insight into the role of caspase-8 in the intestinal epithelium.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE30873

6 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

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(Submitter supplied) Microarray analysis of IECs from Tlr5+/+ and Tlr5-/- mice stimulated with either medium alone or flagellin (1 µg/ml); to elucidate TLR5-mediated immune responses in CD11c+ LPCs Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2212

Platform:

GPL1261

4 Samples

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(Submitter supplied) Microarray analysis of IECs from Tlr5+/+ and Tlr5–/– mice stimulated with either medium alone or flagellin (1 µg/ml); to elucidate TLR5-mediated immune responses in IECs. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2211

Platform:

GPL1261

4 Samples

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Analysis of CD11c positive intestinal lamina propria cells (LPC) from toll-like receptor 5 (TLR5) null animals stimulated with flagellin. TLR5 mediates the immune response to flagellin. Results provide insight into the role of CD11c positive LPCs in the innate immune response mediated by TLR5.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE5113

4 Samples

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Analysis of intestinal epithelial cells (IECs) from toll-like receptor 5 (TLR5) null animals stimulated with flagellin. TLR5 mediates the immune response to flagellin. Results provide insight into the role of IECs in the innate immune response mediated by TLR5.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE5112

4 Samples

Download data