Similar studies for GEO DataSets (Select 200187052) - GEO DataSets

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Items: 19

Select item 2001870521.

RNASeq profiles from two distinct F4/80+VCAM1+ sorted bone marrow populations are consistent with non-macrophage cells coated with macrophage fragments

(Submitter supplied) The objective of this study was to characterise macrophage subsets in bone marrow (BM) isolated from Csf1r-EGFP mice. A concurrent imaging flow cytometry study conducted by our team unexpectedly revealed macrophage surface marker staining emanates from membrane-bound subcellular remnants associated with unrelated cells. Expression data from sorted BM “macrophage” populations was found to be consistent with macrophage fragments associated with non-macrophage cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE187052

ID:: 200187052

PubMed Similar studies SRA Run Selector

Select item 2001863612.

Gene expression in sorted myeloid population from mice

(Submitter supplied) Cells expressing macrophage markers (Cd11b+F4/80+CD169+CX3CR1neg) were sorted from the bone marrow of C57BL/6 mice and their gene expression profile analysed using RNA sequencing. Analysis of the most highly expressed genes revealed a gene expression signature consistent with a granulocyte population (i..e high expression of Ly6g and Cxcr2), rather than macrophages (i.e. low/negligible expression of Adgre1, Cd163 and Mertk). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: TXT

Series

Accession:: GSE186361

ID:: 200186361

PubMed Similar studies SRA Run Selector

Select item 2000990953.

Single-cell RNA-seq reveals differentiation hierarchy of normal human bone marrow and a distinct transcriptome signature of aneuploid cells

(Submitter supplied) In order to get a better understanding of the gene signature of aneuploid cells, we applied single cell RNA sequencing on human bone marrow cells from healthy donors and patients with bone marrow failure and cytogenetic abnormalities. We chacterized normal hemaopoiesis as binary differentiation and identified aneuploid cells from patient samples.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21290 GPL16791
1202 Samples

Download data: CSV, GTF

Series

Accession:: GSE99095

ID:: 200099095

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Select item 2002534854.

Circulating Hematopoietic Stem/Progenitor Cell subsets contribute to human hematopoietic homeostasis

(Submitter supplied) In physiological conditions, few circulating hematopoietic stem/progenitor cells (cHSPC) are present in peripheral blood (PB) and their role remain unsolved. By integrating advanced immunophenotyping, high-throughput transcriptome profiling and functional assays we characterized the biological properties of human cHSPC. We found distinct composition but comparable bone marrow (BM) homing and differentiation potential after xenotransplantation of cHSPC with respect to their BM counterpart. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL21697 GPL24676
30 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE253485

ID:: 200253485

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Select item 2001205815.

Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by array

Platforms:: GPL18413 GPL23085 GPL21741
97 Samples

Download data: TXT

Series

Accession:: GSE120581

ID:: 200120581

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Select item 2001205786.

Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [Bulk RNA-seq]

(Submitter supplied) To characterize the distinct features of HSPCs and relevant niche cells, we performed RNA-seq with sorted zebrafish HSPCs and niche cells, based on fluorescent protein labeling from distinct regions at six relatively discrete stages.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21741
24 Samples

Download data: TXT

Series

Accession:: GSE120578

ID:: 200120578

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Select item 2001205097.

Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [RNA-seq]

(Submitter supplied) To decode the complexed mechanism controlling HSC expansion, from the viewpoint of systems biology, we performed spatial transcriptome analysis by dissecting the whole hematopoietic organ, CHT.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
72 Samples

Download data: TXT

Series

Accession:: GSE120509

ID:: 200120509

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Select item 2001205038.

Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [10x]

(Submitter supplied) To investigate the peculiarity of CHT HSPCs, as well as the interaction of CHT niche and HSPCs at higher resolution, we performed scRNA-seq with zebrafish CHT.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23085
1 Sample

Download data: TXT

Series

Accession:: GSE120503

ID:: 200120503

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Select item 2002463519.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL27943
13 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE246351

ID:: 200246351

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Select item 20024635010.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques [RNA-seq]

(Submitter supplied) To understand the ontogeny and longevity of tissue-resident macrophages in nonhuman primates (NHPs), we employ a model of autologous hematopoietic stem progenitor cell (HSPC) transplantation with HSPCs genetically modified to be marked with clonal barcodes, allowing for subsequent analysis of clonal ontogeny.

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27943
4 Samples

Download data: TSV, TXT

Series

Accession:: GSE246350

ID:: 200246350

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Select item 20024634811.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques [ATAC-seq]

Organism:: Macaca mulatta

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL27943
9 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE246348

ID:: 200246348

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Select item 20015556912.

Single-cell RNA sequencing of Cd45+ adventitial cells from mice at steady state or treated with AngiotensinII

(Submitter supplied) Here we show, that arterial macrophages derive predominantly from YS EMPs, which give rise to a transcriptionally distinct cluster of macrophages with mainly homeostatic and anti-inflammatory properties in steady state as well as in response to AngII inflammation. In adult mice, these EMP-derived macrophages persist for long periods of time, but decreas in absolute numbers in senescence without compensation by BM-derived progenitors. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE155569

ID:: 200155569

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Select item 20002197313.

A revised map of the human progenitor hierarchy reveals origin of macrophages and dendritic cells in early lymphoid development

(Submitter supplied) The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model has recently been questioned in the mouse, however little is known concerning lineage potential of human progenitors. Here we provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of 7 progenitor classes from neonatal cord blood and adult bone marrow. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
16 Samples

Download data: TXT

Series

Accession:: GSE21973

ID:: 200021973

Select item 20019655314.

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
7 Samples

Download data: TSV

Series

Accession:: GSE196553

ID:: 200196553

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Select item 20019655215.

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [HSCP]

(Submitter supplied) Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly formed stem cells. We observed intimate and specific interactions between macrophages and blood stem cells in zebrafish embryos. Stressed stem cells were marked by surface Calreticulin, which stimulates macrophage interaction as an “eat me” signal. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
5 Samples

Download data: TSV

Series

Accession:: GSE196552

ID:: 200196552

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Select item 20019655116.

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [macrophages]

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
2 Samples

Download data: TSV

Series

Accession:: GSE196551

ID:: 200196551

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Select item 20020697717.

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL21273
19 Samples

Download data: H5

Series

Accession:: GSE206977

ID:: 200206977

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Select item 20020697618.

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelial cells [scRNA-Seq]

(Submitter supplied) Heterogeneity of endothelial cell populations reflects their diverse functions in maintaining tissue’s homeostasis. However, their phenotypic, molecular, and functional properties are not entirely mapped. We used a new Tie2-CreERT2;Rosa26-tdTomato reporter mouse to trace, profile, and cultivated primary ECs from different organs. As platform paradigm, we used this strategy to study bone marrow endothelial cells (BMEC). more...