Similar studies for GEO DataSets (Select 200195924) - GEO DataSets

Select item 2001959241.

A Combination of Chemotherapy and Oncolytic Virotherapy Sensitizes Colorectal Adenocarcinoma to Immune Checkpoint Inhibitors in a cDC1-Dependent Manner

(Submitter supplied) Comparison of transcriptome data in tumors from mice treated with combinations of mitomycin C, oncolytic HSV-1, anti-PD-1 and anti-CTLA-4.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
30 Samples

Download data: CEL

Series

Accession:: GSE195924

ID:: 200195924

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001455342.

Effect of Flt3L and DNGR-1 on the biology of tumor-infiltrating type 1 dendritic cells

(Submitter supplied) DNGR-1 is a dead cell-sensing receptor specifically expressed in type 1 conventional dendritic cells (cDC1s), but whether it plays a role in antitumor immunity remains unexplored. In our work we have explored the transcriptional profile of tumor-infiltrating cDC1s competent or deficient in DNGR-1,

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: XLS

Series

Accession:: GSE145534

ID:: 200145534

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001524513.

Intravenous injection of oncolytic virus M1 awakes antitumor T cells and overcomes resistance to checkpoint blockade

(Submitter supplied) Gene set enrichment analysis (GSEA) revealed that upon M1 treatment, apoptotic and inflammation associated genes were largely upregulated, suggesting that M1 killed tumor cells and triggered inflammatory response. The GSEA also revealed that DNA repair pathway was down-regulated in M1 treated tumors, which is consistent with our previous finding that M1 induces DNA damage and then leads to tumor cells apoptosis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
8 Samples

Download data: XLSX

Series

Accession:: GSE152451

ID:: 200152451

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001492064.

Dickkopf 1 Impairs Sensitivity to PD-1 Blockade through CD8+ T Cell Inactivation in dMMR/MSI Colorectal Cancer

(Submitter supplied) Dickkopf 1 (DKK1) could promote tumor progression by suppressing immunity. Therefore, we investigated whether DKK1 influence prognosis and sensitivity to PD-1 blockade in colorectal cancers (CRCs) with defective DNA mismatch repair genes (dMMR) or microsatellite instability (MSI). We found that elevated DKK1 expression was associated with recurrence and dismissed CD8+ T cell infiltrations, and patients with high serum DKK1 had poor anti-PD-1 response. more...