GEO DataSets

(Submitter supplied) In this exploratory post-hoc analysis of clinical trial samples (clinicalTrials.gov: NCT01424501), we compared gene expression patterns elicited by two immunizations with the candidate tuberculosis (TB) vaccine M72/AS01, between three groups of individuals with different levels of memory responses to TB antigens before vaccination

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

262 Samples

Download data: CEL

(Submitter supplied) Systems biology has the potential to identify gene signatures associated with vaccine immunogenicity or protective efficacy. The main objective of our study was to identify optimal post-vaccination time points for evaluating blood RNA-expression profiles in recipients of the candidate tuberculosis vaccine M72/AS01. In this phase II open-label study (NCT01669096), healthy Bacillus Calmette-Guérin (BCG)-primed, HIV-negative adults were administered two doses (30-days apart) of M72/AS01. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

164 Samples

Download data: CEL

(Submitter supplied) In a phase 3 trial in African infants/children, the RTS,S/AS01 (GSK) vaccine showed moderate efficacy against clinical malaria. We aimed to identify RTS,S/AS01-induced signatures associated with clinical malaria by analyzing antigen-stimulated peripheral blood mononuclear cells sampled from a subset of trial participants at baseline and month 3 (one month post-final dose). RTS,S/AS01 vaccination was associated with downregulation of B-cell and monocyte-related blood transcriptional modules (BTMs) and upregulation of T-cell related BTMs, as well as higher month 3 (vs baseline) (CSP)-specific CD4+ T-cell responses. more...

Organism:

Homo sapiens; blank sample

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL29107

1925 Samples

Download data: TSV

(Submitter supplied) The analysis was performed in 2 parts: a descriptive analysis of the response within each adjuvant group and an analysis at the individual subject level. We used blood transcriptional modules to perform interpretation of the results.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

924 Samples

Download data: CEL, XLSX

(Submitter supplied) Analyzed the gene expression changes in infant of 2 month old after vaccination of HepB, DTaP, Hib, IPV, PCV13, and RV vaccines in 7 days and 30 days

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

68 Samples

Download data: TXT

(Submitter supplied) Infants necessitate vaccinations to prevent life-threatening infections. Our understanding of the infant immune responses to routine vaccines remains limited. We analyzed two cohorts of 2-month-old infants before vaccination, one week, and one-month post-vaccination. We report remarkable heterogeneity but limited antibody responses to the different antigens. Whole-blood transcriptome analysis in an initial cohort showed marked overexpression of interferon-stimulated genes (ISGs) and to a lesser extent of inflammation-genes at day 7, which normalized one month post-vaccination. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

18 Samples

Download data: MTX, TSV